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Anti-aging co-transport nanolipid vesicle and preparation method and application thereof

A nano-lipid and vesicle technology, which is applied in anti-toxic agents, pharmaceutical formulas, cosmetic preparations, etc., can solve problems such as unstable active ingredients, inactivation, and single anti-aging mechanism, so as to accelerate skin metabolism and stimulate natural regeneration Excellent function and skin feel

Inactive Publication Date: 2018-12-21
WUHAN BEST CARRIER NANO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. Single anti-aging mechanism: Most anti-aging patented inventions only target the anti-oxidation mechanism. For example, the patent CN106265124A only contains two active ingredients of ceramide 2 and carnosine, which cannot achieve full anti-aging;
[0005] 2. Unable to improve the stability of active ingredients: most peptides, vitamins and phenolic active substances with anti-aging effects are sensitive to enzymes, light, pH, etc., if they are directly added to the formula without nano-encapsulation treatment (see patent CN108498445A ), easily lead to inactivation of unstable active ingredients;
[0006] 3. It is difficult to guarantee transdermal absorption of anti-aging active ingredients: due to the skin's own barrier, anti-aging active ingredients such as active peptides are difficult to penetrate the stratum corneum of the skin and act on the skin care target parts, and the anti-aging function has little effect

Method used

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  • Anti-aging co-transport nanolipid vesicle and preparation method and application thereof
  • Anti-aging co-transport nanolipid vesicle and preparation method and application thereof
  • Anti-aging co-transport nanolipid vesicle and preparation method and application thereof

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preparation example Construction

[0086] The present invention provides a method for preparing the anti-aging co-delivery nano-lipid vesicles described in the above scheme, comprising the following steps:

[0087] 1) mixing complex phospholipids, cholesterol, non-water-soluble anti-aging active ingredients and nonionic surfactants to obtain an oil phase;

[0088] 2) mixing water-soluble anti-aging active ingredients, water-soluble alcohol and water to obtain an aqueous phase;

[0089] 3) After mixing the oil phase of the step 1) and the water phase of the step 2), emulsification and micronization are carried out successively to obtain a micron-scale dispersion;

[0090] 4) Nano-processing the micron-scale dispersion in step 3) to obtain anti-aging co-delivery nano-lipid vesicles;

[0091] The steps 1) and 2) are not limited in time sequence.

[0092] The invention mixes complex phospholipids, cholesterol, water-insoluble anti-aging active ingredients and nonionic surfactants to obtain an oil phase.

[0093]...

Embodiment 1

[0103] According to mass percentage, 1% hydrogenated lecithin (phosphatidylcholine 25% ~ 30%), 3.0% soybean lecithin PC-50, 0.1% cholesterol, 2.0% vitamin E, 0.5% decarboxylated carnosine, 2.0% silymarin , 1.0% epigallocatechin gallate and 5% polyglycerol-10 myristate were melted in a water bath at 50°C to obtain an oil phase for subsequent use;

[0104] 0.5% carnosine, 0.1% astaxanthin, 1.0% raspberry extract, 0.1% VC, 0.01% palmitoyl pentapeptide-3, 0.01% acetyl hexapeptide-8, 5% 1,3-butanediol, Mix 20% propylene glycol with the rest of the water, stir in a water bath at 50°C to obtain a water phase, and set aside;

[0105] Mix the water phase with the oil phase, and after the mixing is completed, high-speed shear emulsification for 5 minutes at a rotation speed of 5500 rpm to obtain a micron-sized dispersion;

[0106] The micron-sized dispersion was emulsified under high-speed shear for 1 min at a rotational speed of 10,000 rpm to obtain anti-aging co-delivery nano-lipid v...

Embodiment 2

[0109] By mass percentage, 1.0% hydrogenated lecithin (phosphatidylcholine 55% ~ 65%), 3.0% hydroxylated lecithin, 1.0% cholesterol, 2.0% curcumin, 1.5% resveratrol, 3.0% thick Parkerol and 10.0% polyglycerol-3 methylglucose distearate were melted in a water bath at 50°C to obtain an oil phase for subsequent use;

[0110] 2.0% Tetrapeptide-30, 0.1% Palmitoyl Tripeptide-1, 1.0% Raspberry Extract, 0.1% VC, 0.01% Palmitoyl Pentapeptide-3, 0.05% Acetyl Hexapeptide-3, 8.0% 1, Mix 2-pentanediol, 8.0% dipropylene glycol and the rest of water, stir in a water bath at 50°C to obtain a water phase, and set aside;

[0111] Mix the water phase with the oil phase, and after the mixing is completed, high-speed shear emulsification for 5 minutes at a rotation speed of 5500 rpm to obtain a micron-sized dispersion;

[0112] The micron-sized dispersion was homogenized three times at a temperature of 30°C and a homogenization pressure of 500 bar to obtain anti-aging co-delivery nano-lipid vesic...

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Abstract

The invention provides an anti-aging co-transport nano lipid vesicle and a preparation method and application thereof, and belongs to the technical field of functional cosmetics. The anti-aging co-transport nano lipid vesicle comprises the following components in parts by weight: 0.02-32 parts of an anti-aging active component, 11.1-65 parts of a nano lipid vesicle, and 3-88 parts of water, wherein the nano lipid vesicle comprises the following raw materials in parts by weight: 5.0-20.0 parts of a nonionic surfactant, 5.0-30.0 parts of water-soluble alcohol, 1.0-10.0 parts of compound phosphatide, and 0.1-5.0 parts of cholesterol; and the anti-aging active component includes a water insoluble anti-aging component and / or a water soluble anti-aging component. According to the preparation method, the anti-aging active components are loaded in the same nano lipid vesicle, so that transdermal co-transport of multi-target-point anti-aging active components of various anti-aging mechanisms can be realized; and synergistic interaction is realized, and thus the anti-aging effect is improved.

Description

technical field [0001] The invention belongs to the field of functional cosmetics, and in particular relates to an anti-aging co-delivery nano-lipid vesicle and a preparation method and application thereof. Background technique [0002] The skin is the most intuitive representation of the age of the human body. Delaying skin aging and making the skin look younger is one of the most important skin care needs of modern women. The causes of skin aging can be divided into endogenous physiological causes and exogenous environmental factors. Physiological internal factors are related to genetic factors, cell aging, weakening of microcirculation, fat accumulation, changes in body hormones, etc. Exogenous environmental factors include ultraviolet radiation, environmental pollution, etc. In addition, diet and living habits, and stress etc. also have an important impact on aging. [0003] At present, there are many anti-aging cosmetics on the market, but these cosmetics are mixed, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/9767A61K8/67A61K8/63A61K8/60A61K8/49A61K8/35A61K8/34A61K8/365A61K8/64A61K8/55A61K8/14A61Q19/08A61Q19/02A61P39/06
CPCA61K8/9789A61K8/14A61K8/347A61K8/35A61K8/365A61K8/4913A61K8/498A61K8/553A61K8/602A61K8/63A61K8/64A61K8/676A61K8/678A61K8/9767A61K2800/592A61K2800/5922A61K2800/782A61P39/06A61Q19/02A61Q19/08
Inventor 刘卫洪延涵罗丹闻庆吴航航
Owner WUHAN BEST CARRIER NANO TECH
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