36 results about "Arthritis pain" patented technology

A composition containing capsicium extract together with other ingredients to neutralize the discomfort resulting from the application of capsicium extract to the skin enabling treatment of many types of discomforts, including arthritis pain, neuropathy, post surgical scarring, hemorrhoid pain and itching, and pruritis without the discomfort normally associated with the topical application of capsicium extract.

Human aggrecanase and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting aggrecanase activity in a host and methods of treating disease conditions associated with aggrecanase activity, e.g. rheumatoid arthritis, osteo-arthritis, infectious arthritis, gouty arthritis, psoriatic arthritis, spondolysis, sports injury, joint trauma, pulmonary disease, fibrosis, and the like.

The invention relates to application of a stilbene derivative and pharmaceutically acceptable salts thereof to preparation of medicines or health-care products for preventing and / or treating hyperuricemia, and acute gout, chronic gout, gouty arthritis, gout attack, uric acid nephrolithiasis and gouty nephropathy caused by the hyperuricemia. The stilbene derivative is used as an active component for preparing the medicines for treating the hyperuricemia, can reduce the concentration of uric acid in blood, has a significant effect on treatment of the hyperuricemia, does not have toxic or side effects and has good safety.

The invention relates to Febuxostat and a drug combination thereof, wherein the Febuxostat is Febuxostat crystal, belonging to monoclinic system, the space group of the crystal is P2 (1), and cell parameters comprise a=4.7179 (9), b=17.813 (4), c=10.690 (2), alpha=gamma=90 degrees, and beta=99.20 (3) degrees; and the cell volume is 886.8(3) <3>. In addition, the invention also relates to a drug composition containing the Febuxostat crystal and a preparation method of the crystal, and simultaneously the invention further discloses application of the Febuxostat crystal in treating hyperuricemia comprising primary and secondary hyperuricemia, acute and chronic gout, gouty arthritis, gouty nephropathy and renal calculus which are caused by the hyperuricemia.

A composition containing capsaicin together with other ingredients to neutralize the discomfort resulting from the application of capsaicin to the ski enabling treatment of many types of discomforts, including arthritis pain, neuropathy, post surgical scarring, hemorrhoid pain and itching, and pruritis without the discomfort normally associated with the topical application of capsaicin.

Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof:are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, COPD, ARDS, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

The invention discloses a compound oral Chinese patent medicament for treating gout, which consists of the following raw materials in percentage by weight based on crude medicaments: 5 to 20 percent of phellodendron, 5 to 20 percent of root of common peony, 5 to 30 percent of sevenlobed yam rhizome, 5 to 30 percent of desmodium, 3 to 10 percent of mastic, 3 to 10 percent of myrrh, 5 to 25 percent of suberect spatholobus stem, 5 to 20 percent of rhizoma atractylodis, 5 to 28 percent of oriental waterplantain rhizome, 5 to 20 percent of medicinal cyathula root, and 5 to 20 percent of root of largeleaf gentian. The invention discloses a preparation method for the medicament, and the formulations of the medicament are tablets, capsules, granules, oral liquid, dropping pills, and other common formulations. The compound oral Chinese patent medicament is used for treating acute and chronic gout, gouty arthritis, gouty stone, and gouty nephrotic syndrome, is a new medicament with obvious curative effects and safe administration for clinical treatment, and has significant application value.

The invention relates to a compound essential oil for relieving arthritis pain, which is prepared by mixing mastic essential oil, myrrh essential oil, turmeric essential oil, gaultheriaííyunnanensis essential oil, fructus liquidambaris essential oil, safflower essential oil, ginger oil and grape-kernel oil in a certain proportion. The invention has good curative effects of warming the channel and quickening the blood, removing obstruction in the channel to stop the pain and promoting the recovery from fatigue.

The invention relates to a health-care product, in particular to a muscle and joint-innerve spraying agent. The invention also relates to a preparation method. Pre 1000 ml muscle and joint-innerve spraying agent is made by the active pharmaceutical ingredient and accessories in the following weight ratio, wherein, the active pharmaceutical ingredient is that: clematis root 50 to 60 g, safflower 5 to 13 g, leech 20 to 35 g, dragon's blood 40 to 50 g, olibanum 10 to 20 g, myrrh 10 to 20 g, monkshood root 15 to 25 g, barrenwort 40 to 60 g, borneol 5 to 12 g, propolis 20 to 30 g, laurocapram 8 to 12g and ethyl fiber 2 to 4 g. the invention is suitable for people with pain caused by cervical spondylosis, scapulahumeral periarthritis, protrusion of lumbar intervertebral discs, osteoarthritis, gout and herpes zoster, and people suffering from lumbocrural pain, muscle soreness and neurogenic headache. The health-care product has the advantages of releasing pain and improving microcirculation.

A Chinese medicine for treating arthrodynia is prepared from 10 Chinese-medicinal materials including Sichuan aconite root, wild aconite root, frankincense, myrrh, etc. Its advantages are high curative effect and no toxic by-effect.

The invention discloses an inflammation-diminishing pain-relieving massage cream containing a marijuana extract and a preparation method thereof, and belongs to the technical field of preparation of amedicine for external use. The inflammation-diminishing pain-relieving massage cream consists of the following raw and auxiliary materials in parts by weight: 15 parts to 25 parts of purified water,15 parts to 30 parts of paraffin wax, 5 parts to 20 parts of vaseline, 20 parts to 40 parts of beewax, 1 part to 10 parts of marijuana extract, 1 part to 10 parts of wintergreen oil, 0.5 part to 5 parts of skin penetration enhancer, 1 part to 10 parts of emulsifier, 5 parts to 15 parts of humectant, 0.1 part to 1 part of essence and 0.1 part to 1 part of preservative. The effective active ingredient, i.e., the marijuana extract, in the massage cream has an obvious relieving effect on pains caused by rheumatalgia, arthritis pain, gout, hyperostosis, various neuralgia, sciatica, myalgia, sprains, traumatic injuries, slight burn wounds, scalds, frostbite and rashes. Meanwhile, the inflammation-diminishing pain-relieving massage cream also has a good inflammation diminishing effect on inflammations caused by bacterial viruses. The massage cream is safe and green, has no side effects, and is simple in process and suitable for industrial production.

The present disclosure is drawn to methods for treating nerve entrapment pain; neuroma pain; headache associated with neuralgia; connective tissue pain such as iliotibial band pain, blood vessel pain, tendinopathy pain, medial tibial stress syndrome pain, bursitis, etc.; arthritis pain such as osteoarthritis pain or rheumatoid arthritis pain; pain associated with injury such as fracture, severance, break, sprain, strain, tear, point pain, (e.g., trigger point pain or hit point pain), focal pain, or bruise; or combinations of these pains. Specifically, a method for treating various types of pain includes the application of an analgesic system to a skin surface of a subject experiencing the pain and maintaining the analgesic system on the skin surface for a period of time of at least 30 minutes. The analgesic system applied to the skin surface can include a heating component and a local anesthetic formulation which includes at least one local anesthetic. The heating component can be capable of heating the skin surface to a temperature of 36° C. to 42° C.

The invention discloses joint pain relieving paste for osseous arthritis pain and relates to the field of traditional Chinese medicine plaster. The joint pain relieving paste is prepared from multiple traditional Chinese medicine through a special technology, special liquid medicine is added for soaking in the preparation process, the joint pain relieving paste is prepared through fumigation of special fumigation materials, according to clinical experience of the inventor, and the joint pain relieving paste can be used for effectively relieving and treating osseous arthritis pain and can be used for thoroughly eradicating the osseous arthritis pain when used for a long time, cotton cloth is used for the plaster, the pungent smell of traditional plaster does not exist in the using process, skin will not be irritated or injured, and meanwhile, the joint pain relieving paste has slight rosin aroma, can be used for treating diseases, is good in nerve soothing effect and can remarkably improve absorption of a human body on medicine.

The invention provides a traditional Chinese medicinal composition for preventing and treating rheumatism, wherein radix gentianae macrophyllae has the efficacy of expelling wind-damp, relaxing muscles and dredging collaterals, and clearing away heat and toxic materials; radix saposhnikoviae has the efficacy of expelling pathogenic wind from the body surface, removing dampness to relieve pain and realizing spasmolysis; Chinese angelica has the effects of promoting blood circulation to arrest pain, and smoothing intestine and relieving constipation; rhizoma chuanxiong has the efficacy of promoting blood and Qi circulation, and dispelling wind and relieving pain; radix paeoniae alba has the efficacy of nourishing blood and retaining Yin with astringent, nourishing liver and relieving pain, and repressing liver Yang; radix rehmanniae preparata has the effects of nourishing blood and Yin, supplementing essence and nourishing marrow; fructus chaenomelis has the efficacy of relaxing tendons and activating collaterals, and removing dampness to restore normal functioning of the stomach; rhizoma seu radix notopterygii has the efficacy of expelling wind and removing cold, and removing dampness to relieve pain; radix angelicae pubescentis has the efficacy of expelling wind and removing cold, and relieving arthritis pain; cortex cinnamomi has the advantages of tonifying fire and helping Yang, and eliminating cold to stop pain; Chinese ephedra herb has the efficacy of relieving exterior syndrome by diaphoresis, and inducing diuresis for removing edema; poria cocos has the efficacy of clearing damp and promoting diuresis, tonifying spleen and calming the nerves; liquorice root has the efficacy of invigorating spleen and replenishing Qi, and relieving medicinal properties; radix scrophulariae has the efficacy of nourishing Yin and promoting the production of body fluid, and resolving toxin and dissipate binds; radix achyranthis bidentatae has the efficacy of strengthening muscles and bones, promoting blood circulation to remove blood stasis, and relieving stranguria by diuresis. By organic combination, the traditional Chinese medicinal composition has remarkable curative effect on rheumatism; by a large amount of clinical applications, good effect is realized.

The invention discloses a medicament for the treatment of rheumatism arthritis pains and a preparation method thereof. The medicament is prepared from coix seeds, papaya, yam rhizome, zaocys dhumnade, gecko, scorpio, herba cistanche and eucommia barks in certain weight proportion. The medicament disclosed by the invention has the effects of clearing damp, relaxing the muscles, dispelling the wind and activating collaterals; and when used for treating rheumatism arthritis pains, the medicament can take effect quickly, is short in course of treatment, and avoid recurrence.

The invention discloses a soothing and pain alleviating gel, which consists of the following components: 10-20 parts of peppermint leaf oil, 5-7 parts of citronella oil, 4-8 parts of eucalyptus oil, 5-20 parts of a cortex eucommiae extract, 5-10 parts of oil of flos rosae rugosae, 3-10 parts of sandalwood oil, 4-10 parts of an extracting solution of radix flemingiae, 3-10 parts of an eucalyptus extracting solution, 2-8 parts of an extracting solution of compositae microglossa pyrifolia, 2-8 parts of an extracting solution of radix cyathulae, 0.5-1.5 parts of a fresh ginger extracting solution, 1-20 parts of water, 2-5 parts of a system stabilizer, 0.05-3 parts of a thickening agent and 0.1-5 parts of ethanol. The prescription adopted by the invention has functions of clearing heat and alleviating pain, promoting blood circulation and removing stasis; and by adopting specially processed male flowers of eucommia ulmoides and on the basis of a complementary and strengthened effect of the male flowers of eucommia ulmoides with other components in the medicine (the gel), the medicine, on stubborn pain, in particular on arthritis pain, traumatic injury and hemorrhoids, has effects of being rapid to take effects, good in curative effect and less in recurrence.

The invention provides a traditional Chinese medicinal ointment for treating lumbar disc herniation. The traditional Chinese medicinal ointment is prepared from the following raw materials: fructus evodiae, pawpaw, radix stephaniae tetrandrae, rhizoma smilacis glabrae, coix seed, radix aconiti lateralis preparata, cassia twig, radix angelicae pubescentis, ligusticum wallichii, divaricate saposhnikovia root, incised notopterygium, frankincense and myrrh. The invention further provides a preparation method of the traditional Chinese medicinal ointment for treating lumbar disc herniation. According to the traditional Chinese medicinal ointment disclosed by the invention, the radix angelicae pubescentis has good functions of dispelling wind and eliminating dampness, relieving arthritis pain; the fructus evodiae is capable of effectively eliminating cold to stop pain; the radix stephaniae tetrandrae has good functions of relieving rheumatic arthralgia; and the incised notopterygium is capable of dispelling wind, overcoming dampness and relieving pain; on this basis, the pawpaw, the rhizoma smilacis glabrae, the coix seed, the radix aconiti lateralis preparata, the cassia twig, the ligusticum wallichii, the saposhnikovia root, the frankincense and the myrrh are added so as to treat lumbar disc herniation; and the traditional Chinese medicinal ointment is effective in treating hyperostosis, arthralgia caused by wind-cold-dampness, arthralgia, pain in waist and legs, lumbar muscle degeneration, numbness of limbs and like symptoms, and is free from any toxic and side effects.

The invention discloses a traditional Chinese medicine composition for treating arthralgia as well as a preparation method, a preparation and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition for treating arthralgia is prepared from the following raw materials: cortex phellodendri, rhizoma corydalis, akebiaquinata, radix angelicae, dragon's blood, radix aucklandiae, radix angelicae pubescentis, notopterygium root, dandelion, moutan bark and rheum officinale. The raw materials are crushed, sieved and mixed to obtain traditional Chinese medicine composition powder; adding water into the raw materials, decocting, removing slag and taking juice to obtain a traditional Chinese medicine composition bath agent; extracting the raw materials with distilled liquor to obtain traditional Chinese medicine composition wine or tincture; the raw materials are extracted, filtered, concentrated and mixed with the matrix to obtain the traditional Chinese medicine composition ointment. The preparation method comprises the following steps: extracting, filtering, purifying and concentrating raw materials, and packaging the raw materials, additives and propellants in a pressure-resistant container with a special valve system to obtain a traditional Chinese medicine composition aerosol or spray or powder aerosol. The traditional Chinese medicine composition is used for treating arthralgia such as rheumatic arthritis, rheumatoid arthritis, osteoarthritis and gout, and is good in medicinal effect and low in toxic and side effects.

The invention provides a novel cell culture fluid sponge patch for relieving arthritis pain, which comprises a long adhesive tape and a round gauze, the round gauze is arranged on the long adhesive tape, the round gauze is a hydrolyzed sponge patch, and the hydrolyzed sponge patch contains a mixture of exosome of umbilical cord stem cells and hydrolyzed sponge. According to the method, in the in-vitro culture of the umbilical cord mesenchymal stem cells, a large amount of cell factor protein is secreted in the culture supernatant, the cell culture supernatant is prepared with the function of effectively relieving local inflammatory reaction and the like, and meanwhile, the characteristics of the hydrolyzed sponge are utilized to help puncture of the outer skin layer, so that the umbilical cord mesenchymal stem cells can be effectively cultured. The method is a brand-new method for promoting cell factors in the culture supernatant to smoothly enter the corium layer through the cuticle.

The invention relates to the technical field of medicines, in particular to a medicine for treating muscle and joint pain. The medicine contains arnica extract, rosemary herb extract, ginger extract, Rhus chinensis root and leaf extract and frankincense extract. The muscle pain, the joint pain and rheumatic pain, which are related to joint diseases are relieved, and the medicine has a synergistic effect. The medicine for treating the muscle and joint pain provides an analgesic effect, so that the pain of patients is effectively reduced; besides, the invention discloses an application of a therapeutically effective dose of the medicine for treating the muscle and joint pain in remarkable relieving of the muscle pain, the arthritis pain and the rheumatic pain which are caused by the joint diseases.

The invention provides a medicine for external use. The medicine for external use is prepared from, by mass, 25-40 parts of spora lycopodii, 15-35 parts of herba senecionis scandentis, 20-40 parts offolium coriariae sinicae, 15-30 parts of radix angelicae pubescentis and 15-30 parts of caulis et folium clerodendri bungei. The medicine for external use has efficacies of wind dispelling, dampness eliminating, meridian activating, heat clearing, detoxicating, inflammation diminishing, itching relieving, swelling and pain relieving, arthritis pain relieving, blood circulation promoting, stasis removing and the like, has remarkable curative effects on traumatic injuries, bone joint pain, skin diseases and tinea pedis and has advantages of quickness in recovery, low recurrence rate, high safety, no toxic and side effects and convenience in manufacturing.

The invention relates to a traditional Chinese medicine and a preparation method thereof, and in particular relates to an external medicine for cervical vertebra and lumbar diseases and arthritis pain. Radix aconiti, asaret, datura flower, borneol, fructus aurantii, ledebouriella root, notoperygium root and the like are prepared into liquid components and paste components according to groups, and when the external medicine is used, the liquid components are sprayed on the paste components. According to the external medicine for treating cervical vertebra and lumbar diseases and arthritis pain, the components are organically combined, the pharmacological action of the components is fully played, and a spray and a paste are organically combined, so that the advantage that the spray can quickly relieve pain is kept, and the drug effect can be prolonged through the paste, the medicinal components can reach focuses, and thus the external medicine has the effect of treating both symptoms and root causes.

The invention relates to a traditional Chinese medicine and a preparation method thereof, and in particular relates to an external medicine for cervical vertebra and lumbar diseases and arthritis pain. Radix aconiti, asaret, datura flower, borneol, fructus aurantii, ledebouriella root, notoperygium root and the like are prepared into liquid components and paste components according to groups, and when the external medicine is used, the liquid components are sprayed on the paste components. According to the external medicine for treating cervical vertebra and lumbar diseases and arthritis pain, the components are organically combined, the pharmacological action of the components is fully played, and a spray and a paste are organically combined, so that the advantage that the spray can quickly relieve pain is kept, and the drug effect can be prolonged through the paste, the medicinal components can reach focuses, and thus the external medicine has the effect of treating both symptoms and root causes.

The invention provides an osteoarthritis auxiliary massage device, and relates to the technical field of medical instruments, the osteoarthritis auxiliary massage device comprises a support mounting part, the support mounting part is slidably connected with a floating connecting device; a smearing massage part is mounted on the floating connecting device; the smearing massage part is fixedly connected with a linkage part; two rows of buffer pressing parts are fixedly connected to the floating connecting device; a ventilation device is mounted on the floating connecting device; the two sides of the supporting installation part are slidably connected with positioning devices correspondingly. Two linkage positioning parts are fixedly connected to the supporting mounting part; the osteoarthritis auxiliary massage device can be more suitable for massage of different body positions, is high in structural linkage, can achieve linkage ventilation and medicine coating massage, is more effective in acupoint massage, comprehensively relieves arthritis pain, and solves the problem that for the osteoarthritis auxiliary massage device, medicine cannot be heated, ventilated and automatically smeared on the whole, and the operation is inconvenient. And automatic attachment massage according to the bones cannot be realized.

The invention relates to a traditional Chinese medicine composition for treating the ache of a human body. The traditional Chinese medicine composition is mainly prepared by processing the following raw materials: eupatorium japonicum, asarum, euonymus alatus, zaocys dhumnade, root of common peony, dogwood, caulis spatholobi, yams and safflower carthamus. An oral preparation or a preparation for external use is prepared from the traditional Chinese medicine composition and auxiliary materials; the oral preparation includes powder, tablets, capsules, syrups, oral liquid, drop pills and water pills; the preparation for external use includes plasters, tinctures, ointments and sprays. The invention further relates a preparation method of the traditional Chinese medicine and the preparation. The traditional Chinese medicine composition is mainly used for treating lumbar disc herniation, sciatica, cervical pain, arthralgia and rheumatism arthritis pain, and has the advantages of being quick-acting, high in healing rate and less in toxic and side effects and ensuring that the diseases do not relapse after being cured.

The invention provides a medicine composition for preventing and treating arthritis. The medicine composition comprises the following components in percentage by weight: 15%-35% of glucosamine hydrochloride, 20%-40% of biological calcium carbonate, 5%-20% of rhizoma drynariae extract, 1%-5% of casein phosphopeptides, 10%-20% of chondroitin sulfate and 10%-30% of epimedium extract. The medicine composition has the advantages of being capable of obviously inhibiting inflammatory cell factors in serum and joint fluid of arthritics patients, relieving the symptoms and signs of the patients, adjusting the immunologic functions of the patients, and effectively preventing and treating diseases such as rheumatism, rheumatoid arthritis, osteoarthritis and gouty arthritis. The invention also provides an application of the medicine composition in the preparation of medicines for preventing and treating diseases such as the rheumatism, the rheumatoid arthritis, the osteoarthritis and the gouty arthritis.

The invention discloses a soothing pain-relieving spraying agent. The soothing pain-relieving spraying agent comprises 0.5 to 1 part of wintergreen oil, 10 to 20 parts of mint leaf oil, 5 to 7 parts of oil of Cymbopogon nardus, 4 to 8 parts of blue gum leaf oil, 5 to 20 parts of eucommia extract, 5 to 10 parts of rose oil, 3 to 10 parts of sandalwood oil, 4 to 10 parts of liquid philippine flemingia root extract, 3 to 10 parts of liquid eucalyptus extract, 2 to 8 parts of liquid Vernonia cumingiana extract, 2 to 8 parts of liquid Radix Cyathulae extract, 0.5 to 1.5 part of ginger extract, 1 to 20 parts of water, 2 to 5 parts of a system stabilizing agent and 0.1 to 5 parts of ethanol. The above recipe is capable of clearing away heat, relieving pain and activating blood circulation to dissipate blood stasis; staminate flowers of eucommia are reinforced in complementation with other components in the recipe after special treatment; and the spraying agent has the advantages of fast action, good curative effect and small possibility of recurrence when applied to treatment of stubborn pain, especially arthritis pain, traumatic injuries and hemorrhoids.