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Poly-L-lactic acid (PLLA) filler for injection and preparation method thereof

一种聚左旋乳酸、填充剂的技术，应用在医药配方、医药科学、假体等方向，能够解决填充剂复溶时间长、易出现皮下结节、混悬液不均匀等问题，达到降解维持时间长、不易漂浮和沉淀、制备工艺优化的效果

Active Publication Date: 2021-05-07
BEIJING JINGYU YIMEI BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiencies such as less choice of poly-L-lactic acid fillers for injection in the current market, long reconstitution time of fillers, uneven suspension, easy occurrence of subcutaneous nodules after injection, and slow onset of action, the present invention provides a Preparation method of poly-L-lactic acid microparticles and preparation method of poly-L-lactic acid filler for injection

Method used

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  • Poly-L-lactic acid (PLLA) filler for injection and preparation method thereof
  • Poly-L-lactic acid (PLLA) filler for injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Preparation of small-diameter poly-L-lactic acid microparticles

[0037] Weigh 30g of poly-L-lactic acid with a viscosity-average molecular weight of 12,000, put it in a three-necked bottle, add a mixed solvent of 600mL of dichloromethane and 1.2L of ethanol, heat to reflux, cool down slightly after the solid is completely dissolved, and the liquid is slightly cloudy, and then Use a peristaltic pump under heating and reflux conditions, drop 300mL of ethanol at a rate of 2mL / min, control the stirring speed during the dropping process to 300-400rpm, pour 600mL of ethanol to dilute after the dropping is completed, evaporate 1L of solvent at normal pressure, add Dilute with 1L of water, cool down to room temperature, filter, rinse the filter cake with ethanol, and pass through a 200-mesh sieve after drying to obtain 28.8 g of poly-L-lactic acid particles with a particle size of D90=12.2 μm.

Embodiment 2

[0038] Example 2 Preparation of medium-sized poly-L-lactic acid microparticles

[0039] Weigh 30g of poly-L-lactic acid with a viscosity-average molecular weight of 38,000, put it in a three-neck bottle, add a mixed solvent of 600mL of dichloromethane and 900mL of ethanol, heat to reflux, and cool down slightly after the solid is completely dissolved. The solution is slightly cloudy, and then heated Under reflux conditions, use a peristaltic pump to drip 600mL of ethanol at a rate of 3mL / min. During the dropping process, control the stirring speed at 200-300rpm. Stir in purified water, cool down to room temperature, filter, rinse the filter cake with ethanol, and pass through a 200-mesh sieve after drying to obtain 29.7 g of poly-L-lactic acid particles with a particle size of D90 = 58.4 μm.

Embodiment 3

[0040] Example 3 Preparation of large-diameter poly-L-lactic acid microparticles

[0041] Weigh 30g of poly-L-lactic acid with a viscosity-average molecular weight of 48,000, put it in a three-neck bottle, add a mixed solvent of 600mL of dichloromethane and 800mL of methanol, heat to reflux, and after the solid is completely dissolved, cool down slightly, the liquid is slightly cloudy, and then Using a peristaltic pump under heating and reflux conditions, add 600mL of methanol dropwise at a rate of 3mL / min. During the dropping process, control the stirring speed at 100-150rpm. After the dropwise addition is completed, pour 400mL of methanol to dilute. The filter cake was washed, dried and passed through a 100-mesh sieve to obtain 28.5 g of poly-L-lactic acid microparticles with a particle size of D90=102.3 μm.

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Abstract

The invention provides poly-L-lactic acid (PLLA) particles and a PLLA filler for injection prepared from the particles. The PLLA particles with different molecular weights and granularities are mixed to prepare the PLLA for injection, and the prepared PLLA for injection can achieve the beautifying effects of quick response and long maintenance time. Compared with an existing product, the PLLA filler has better redissolving and suspending effects, can reduce subcutaneous nodules, remarkably improves the comfort of a user, and provides a new choice for the field of medical cosmetology.

Description

technical field [0001] The invention relates to a preparation method of poly-L-lactic acid microparticles and a preparation method of poly-L-lactic acid filler for injection, belonging to the technical field of polymer medical supplies. Background technique [0002] Poly-L-lactic acid (PLLA) is a degradable polymer material developed rapidly since the 1990s. It is formed by catalytic polymerization of lactic acid, a product of microbial fermentation, as a monomer. [0003] PLLA is widely used in the field of medical beauty. Unlike simple fillers (such as hyaluronic acid, calcium hydroxyapatite, etc.), PLLA is a synthetic dermal filler that can stimulate the growth of subcutaneous collagen. PLLA induces a foreign body giant cell response that gradually produces collagen. During this process, the molecular structure of PLLA is gradually destroyed and slowly hydrolyzed into lactic acid. Lactic acid can stimulate the formation of collagen in the human body, leading to the proli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/20A61L27/50A61L27/58
CPCA61L27/18A61L27/20A61L27/50A61L27/58A61L2400/06C08L67/04C08L1/286
Inventor 张喜清
Owner BEIJING JINGYU YIMEI BIOTECHNOLOGY CO LTD
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