The invention discloses carbazochrome sodium sulfonate oral disintegrating tablets and a preparation method thereof. The carbazochrome sodium sulfonate oral disintegrating tablets are prepared from the following components in percentage by mass: 1-15% of carbazochrome sodium sulfonate, 50-90% of filler, 5-40% of disintegrant, 1-8% of adhesive, 0.1-5% of lubricant and 0.1-5% of flavoring agent. The oral disintegrating tablets have the advantages of smooth surface, attractive appearance, moderate hardness, quick absorption, quick effect taking, small liver first-pass effect, high bioavailability, little irritation to the gastrointestinal tract, favorable mouthfeel and convenient taking, can quickly disintegrate in the oral cavity without water, is particularly suitable for aged people, children, patients in bed or with dysphagia, and especially for bleeding patients inconvenient to drink water during or after operations. The oral disintegrating tablets are prepared in a wet-method pelletizing tabletting way. The preparation method has the advantages of simple production technology, stable and easily-controlled preparation quality, and low cost, and is suitable for industrial large-scale production.