55 results about "Carbazochrome Sodium Sulfonate" patented technology

The invention discloses an injection carbazochrome sodium sulfonate suspension and a preparation method thereof, relating to the technical field of medicines. The injection carbazochrome sodium sulfonate suspension is a powder injection and comprises the following components in parts by weight: 1 part of carbazochrome sodium sulfonate, 1.5-8.5 parts of pharmaceutically acceptable biological carrier, 0.1-1.8 parts of stabilizing agent and 2-5 parts of freezing protective agent. According to the invention, the stability and the dissolvability of the carbazochrome sodium sulfonate are improved, the injection carbazochrome sodium sulfonate suspension has no remarkable change of various indexes through detection after being placed for a long time, the quality of the injection carbazochrome sodium sulfonate suspension within a valid period is ensured to be qualified; and the injection carbazochrome sodium sulfonate suspension can be slowly administrated for a long time, thus bioavailability is greatly improved. The pharmaceutically acceptable biological carrier, i.e. protein, is degraded in vivo without toxicity and immunogenicity; and meanwhile, medicine therapeutic indexes can be effectively increased, and medicine toxicity is lowered and medicine side effects are reduced.

The invention discloses a carbazochrome sodium sulfonate freeze-dried powder injection and preparation method thereof, and the carbazochrome sodium sulfonate freeze-dried powder injection is composed of carbazochrome sodium sulfonate, mannitol, and buffer salts, wherein the solvent for preparation is injection water. Through a great number of tests, the problems of unstable pH value during the preparation of the carbazochrome sodium sulfonate freeze-dried powder injection and unqualified clarity during storage are solved only by adding buffer salts. The process of the prescription of the present invention overcomes the disadvantages of the prior arts, and provides a carbazochrome sodium sulfonate freeze-dried powder injection with the advantages of simple prescription, guaranteed quality and good stability; and is suitable for clinical applications. The present invention also achieves the advantages that: (1) the prescription is simple, wherein in addition to using carbazochrome sodium sulfonate as the main drug, the excipients in the prescription are only mannitol and buffer salts; (2) raw materials and excipients used in the prescription are all medicinal injection grade prescribed by the State Food and Drug Administration so as to eliminate the risk of unpredictable adverse reactions caused by non-pharmaceutical excipients; (3) the stability is good and the prescription is convenient for transportation and storage; (4) no hemolysis, agglutination, irritation, or allergic reactions are observed throughout special safety tests such as allergenicity, hemolytic activity andvascular irritation tests.

The present invention is slow released carbazochrome sodium sulfonate matrix tablet and its preparation process. The recipe of the slow released carbazochrome sodium sulfonate matrix tablet includes carbazochrome sodium sulfonate 5-85 wt%, matrix material 10-90 wt%, diluent 0-80 wt%, and proper amount of adhesive and lubricant. It is prepared through mixing material powder and direct tabletting; or pelletizing the mixture of materials except lubricant, mixing with lubricant and tabletting; or preparing fast release part, preparing slow releasing part and double-layered tabletting. The pelletizing may be wet pelletizing, dry pelletizing, smelting palletizing, etc.

The invention provides a preparation method of a carbazochrome sodium sulfonate freeze-dried powder injection. The method comprises the following steps: (a) mixing carbazochrome sodium sulfonate with first injection water, and sequentially carrying out pH value adjustment and adsorption treatment to obtain a mixed solution A; and (b) mixing the mixed solution A with second injection water, and sequentially freezing and drying to obtain the carbazochrome sodium sulfonate freeze-dried powder injection, wherein the volume ratio of the first injection water to the second injection water is 6 to (3-5). Compared with the prior art, according to the preparation method provided by the invention, the content of impurities in the carbazochrome sodium sulfonate freeze-dried powder injection can be effectively controlled, and the re-dissolving time of a product is shortened. An experiment result shows that the content of the impurities in the carbazochrome sodium sulfonate freeze-dried powder injection prepared by the preparation method provided by the invention is lower than 0.5%, and the re-dissolving time is within 8 seconds.

Disclosed is a hemostatic injection of carbazochrome sodium sulfonate and method for preparation, wherein the injection comprises carbazochrome sodium sulfonate 0.005-0.5 wt%, the optimum content being 0.008-0.2%, auxiliary solvent 0.001-0.5 wt%, the optimum content being 0.002-0.1%, osmoregulation agent 0.8-15 wt%, and water for injection 84.0-99.1%. The preparing process consists of boiling, filtering, removing charcoal, adjusting pH to 4.5-6.5, passing soup through a charcoal layer, loading into transfusion bottles, venting nitrogen, rolling the caps, and sterilizing.

The invention provides a medicinal composition containing carbazochrome sodium sulfonate compound and a preparation method thereof. The medicinal composition containing carbazochrome sodium sulfonate compound consists of carbazochrome sodium sulfonate, mannitol, dextran and sodium hydroxide. The medicinal composition containing carbazochrome sodium sulfonate compound can solves the problems of low stability, low solubility and the like of the conventional carbazochrome sodium sulfonate powder injection and is more suitable for use in clinic.

The invention belongs to the field of medicine, and relates to a pharmaceutical composition containing pentoxifylline and carbazochrome sodium sulfonate and application thereof. The pharmaceutical composition contains the active components pentoxifylline and carbazochrome sodium sulfonate, has the efficacies of diminishing inflammation, arresting bleeding, improving the vascular permeability and the like in treating hemorrhagic hemorrhoids, is obviously superior to the single drugs of pentoxifylline and carbazochrome sodium sulfonate in therapeutic action, and has a synergistic action.

The invention discloses a carbazochrome sodium sulfonate freeze-dried powder injection and preparation method thereof, and the carbazochrome sodium sulfonate freeze-dried powder injection is composed of carbazochrome sodium sulfonate, mannitol, and buffer salts, wherein the solvent for preparation is injection water. Through a great number of tests, the problems of unstable pH value during the preparation of the carbazochrome sodium sulfonate freeze-dried powder injection and unqualified clarity during storage are solved only by adding buffer salts. The process of the prescription of the present invention overcomes the disadvantages of the prior arts, and provides a carbazochrome sodium sulfonate freeze-dried powder injection with the advantages of simple prescription, guaranteed quality and good stability; and is suitable for clinical applications. The present invention also achieves the advantages that: (1) the prescription is simple, wherein in addition to using carbazochrome sodium sulfonate as the main drug, the excipients in the prescription are only mannitol and buffer salts; (2) raw materials and excipients used in the prescription are all medicinal injection grade prescribed by the State Food and Drug Administration so as to eliminate the risk of unpredictable adverse reactions caused by non-pharmaceutical excipients; (3) the stability is good and the prescription is convenient for transportation and storage; (4) no hemolysis, agglutination, irritation, or allergic reactions are observed throughout special safety tests such as allergenicity, hemolytic activity andvascular irritation tests.

The invention discloses carbazochrome sodium sulfonate oral disintegrating tablets and a preparation method thereof. The carbazochrome sodium sulfonate oral disintegrating tablets are prepared from the following components in percentage by mass: 1-15% of carbazochrome sodium sulfonate, 50-90% of filler, 5-40% of disintegrant, 1-8% of adhesive, 0.1-5% of lubricant and 0.1-5% of flavoring agent. The oral disintegrating tablets have the advantages of smooth surface, attractive appearance, moderate hardness, quick absorption, quick effect taking, small liver first-pass effect, high bioavailability, little irritation to the gastrointestinal tract, favorable mouthfeel and convenient taking, can quickly disintegrate in the oral cavity without water, is particularly suitable for aged people, children, patients in bed or with dysphagia, and especially for bleeding patients inconvenient to drink water during or after operations. The oral disintegrating tablets are prepared in a wet-method pelletizing tabletting way. The preparation method has the advantages of simple production technology, stable and easily-controlled preparation quality, and low cost, and is suitable for industrial large-scale production.

The invention relates to the technical field of medicine, and discloses a suspensoid of sodium carbosulfonate for injection and a preparation method thereof. Composition, the parts by weight of each component are: 1 part of sodium carbosulfonate; 1.5-8.5 parts of a pharmaceutically acceptable biological carrier; 0.1-1.8 parts of a stabilizer; and 2-5 parts of a freeze-drying protective agent. The present invention improves the stability and solubility of the sodium carbosulfonate, and there is no obvious change in various indicators detected after long-term storage, ensuring that the product quality is qualified within the validity period; it can be administered slowly for a long time, and the bioavailability is greatly improved. The pharmaceutically acceptable biological carrier, that is, the protein, is degraded in the body, has no toxicity and no immunogenicity, and can effectively improve the therapeutic index of the drug, reduce the toxicity of the drug and reduce the side effects of the drug.

The invention relates to the technical field of medicines and in particular relates to a carbazochrome sodium sulfonate semisolid preparation and a preparation method thereof. The preparation method comprises the following steps: with high-purity carbazochrome sodium sulfonate with the purity above 99.80 percent as an active ingredient, adding a medical matrix to prepare one of suppository, ointment and gel; wherein every10g of the suppository contains 20-80mg of carbazochrome sodium sulfonate; the ointment per 10g contains 40-80mg of the carbazochrome sodium sulfonate; every 5g of the gel contains 40-80mg of the carbazochrome sodium sulfonate. According to the carbazochrome sodium sulfonate semisolid preparation and the preparation method disclosed by the invention, the purity of the carbazochrome sodium sulfonate serving as the active ingredient is above 99.80 percent and by-products are controlled to be below 0.2 percent; when the carbazochrome sodium sulfonate semisolid preparation is used, the adverse reaction incidence in the medication process can be lowered and the medication safety can be improved; meanwhile, the prepared carbazochrome sodium sulfonate semisolid preparation can be delivered by virtue of body cavities so that the high-purity carbazochrome sodium sulfonate is capable of improving the medication safety while high bioavailability of a product is ensured.