Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
Hiro

55 results about "Carbazochrome Sodium Sulfonate" patented technology

Carbazochrome is an antihemorrhagic, or hemostatic, agent that will cease blood flow by causing the aggregation and adhesion of platelets in the blood to form a platelet plug, ceasing blood flow from an open wound.

Injection carbazochrome sodium sulfonate suspension and preparation method thereof

The invention discloses an injection carbazochrome sodium sulfonate suspension and a preparation method thereof, relating to the technical field of medicines. The injection carbazochrome sodium sulfonate suspension is a powder injection and comprises the following components in parts by weight: 1 part of carbazochrome sodium sulfonate, 1.5-8.5 parts of pharmaceutically acceptable biological carrier, 0.1-1.8 parts of stabilizing agent and 2-5 parts of freezing protective agent. According to the invention, the stability and the dissolvability of the carbazochrome sodium sulfonate are improved, the injection carbazochrome sodium sulfonate suspension has no remarkable change of various indexes through detection after being placed for a long time, the quality of the injection carbazochrome sodium sulfonate suspension within a valid period is ensured to be qualified; and the injection carbazochrome sodium sulfonate suspension can be slowly administrated for a long time, thus bioavailability is greatly improved. The pharmaceutically acceptable biological carrier, i.e. protein, is degraded in vivo without toxicity and immunogenicity; and meanwhile, medicine therapeutic indexes can be effectively increased, and medicine toxicity is lowered and medicine side effects are reduced.
Owner:SHANGHAI JINCHENG PHARMACEUTICAL CO LTD

Carbazochrome sodium sulfonate freeze-dried powder injection and preparation method thereof

The invention discloses a carbazochrome sodium sulfonate freeze-dried powder injection and preparation method thereof, and the carbazochrome sodium sulfonate freeze-dried powder injection is composed of carbazochrome sodium sulfonate, mannitol, and buffer salts, wherein the solvent for preparation is injection water. Through a great number of tests, the problems of unstable pH value during the preparation of the carbazochrome sodium sulfonate freeze-dried powder injection and unqualified clarity during storage are solved only by adding buffer salts. The process of the prescription of the present invention overcomes the disadvantages of the prior arts, and provides a carbazochrome sodium sulfonate freeze-dried powder injection with the advantages of simple prescription, guaranteed quality and good stability; and is suitable for clinical applications. The present invention also achieves the advantages that: (1) the prescription is simple, wherein in addition to using carbazochrome sodium sulfonate as the main drug, the excipients in the prescription are only mannitol and buffer salts; (2) raw materials and excipients used in the prescription are all medicinal injection grade prescribed by the State Food and Drug Administration so as to eliminate the risk of unpredictable adverse reactions caused by non-pharmaceutical excipients; (3) the stability is good and the prescription is convenient for transportation and storage; (4) no hemolysis, agglutination, irritation, or allergic reactions are observed throughout special safety tests such as allergenicity, hemolytic activity andvascular irritation tests.
Owner:HAINAN LEVTEC PHARMA

Special ultrafine carbazochrome sodium sulfonate powder freeze-dried preparation and preparation method thereof

The invention discloses a special ultrafine carbazochrome sodium sulfonate powder freeze-dried preparation and a preparation method thereof. The method comprises the following steps: step 1, dissolving carbazochrome sodium sulfonate in water, adding sodium bisulfite and carrying out a reaction so as to prepare a mixed liquor; step 2, adding a decolorant into the mixed liquor for decoloring and carrying out filtering so as to obtain a filtrate; step 3, adjusting the pH value of the filtrate by using sodium hydroxide, carrying out cooling, allowing a crystal to be precipitated and then successively carrying out filtering, washing and vacuum drying so as to obtain carbazochrome sodium sulfonate; and step 4, carrying out air jet pulverization on dried carbazochrome sodium sulfonate, dissolving special ultrafine powder of carbazochrome sodium sulfonate in injection water, carrying out low-temperature pre-freezing, then carrying out low-temperature pressure-reduced vacuum drying and finally, carrying out high temperature drying so as to prepare the special ultrafine carbazochrome sodium sulfonate powder freeze-dried preparation. The special ultrafine carbazochrome sodium sulfonate powder freeze-dried preparation prepared in the invention has the advantages of high stability, high purity, a few impurities, a small size, a great specific surface area, good dissolvability, small toxic and side effects, uneasy incurrence of irritability, etc.
Owner:杭州长典老一元健康管理有限公司

Carbazochrome sodium sulfonate freeze-dried powder injection and preparation method thereof

The invention discloses a carbazochrome sodium sulfonate freeze-dried powder injection and preparation method thereof, and the carbazochrome sodium sulfonate freeze-dried powder injection is composed of carbazochrome sodium sulfonate, mannitol, and buffer salts, wherein the solvent for preparation is injection water. Through a great number of tests, the problems of unstable pH value during the preparation of the carbazochrome sodium sulfonate freeze-dried powder injection and unqualified clarity during storage are solved only by adding buffer salts. The process of the prescription of the present invention overcomes the disadvantages of the prior arts, and provides a carbazochrome sodium sulfonate freeze-dried powder injection with the advantages of simple prescription, guaranteed quality and good stability; and is suitable for clinical applications. The present invention also achieves the advantages that: (1) the prescription is simple, wherein in addition to using carbazochrome sodium sulfonate as the main drug, the excipients in the prescription are only mannitol and buffer salts; (2) raw materials and excipients used in the prescription are all medicinal injection grade prescribed by the State Food and Drug Administration so as to eliminate the risk of unpredictable adverse reactions caused by non-pharmaceutical excipients; (3) the stability is good and the prescription is convenient for transportation and storage; (4) no hemolysis, agglutination, irritation, or allergic reactions are observed throughout special safety tests such as allergenicity, hemolytic activity andvascular irritation tests.
Owner:HAINAN LEVTEC PHARMA

Carbazochrome sodium sulfonate freeze-dried powder injection and preparation method thereof

The invention belongs to the field of pharmaceutical preparations and particularly relates to a carbazochrome sodium sulfonate freeze-dried powder injection and a preparation method thereof. The carbazochrome sodium sulfonate freeze-dried powder injection comprises raw materials as follows: 10-50 parts of carbazochrome sodium sulfonate by weight and 1,800-2,200 parts of water for injection by volume. The freeze-dried powder injection has a good appearance property (orange-yellow freeze-dried cakes or powder) and has the lower impurity content, the change of the impurity content is slighter under high temperature and light conditions, the content of the carbazochrome sodium sulfonate is stable, and the quality stability is better. According to the preparation method of the carbazochrome sodium sulfonate freeze-dried powder injection, through the step that programmed temperature rise is adopted in freeze-drying treatment, the temperature rise speed is controlled, the carbazochrome sodium sulfonate is fully freeze-dried and formed in the stepped temperature change environment, and the good appearance property and better quality stability are obtained; besides, the preparation method only takes less than 17 h for freeze-drying, the freeze-drying time is greatly shortened, and industrial production is facilitated.
Owner:SUZHOU SIXTH PHARMA PLANT OF JIANGSU WUZHONG PHARMA GROUP

A kind of sodium carbosulfonate semi-solid preparation and preparation method thereof

The invention relates to the technical field of medicines and in particular relates to a carbazochrome sodium sulfonate semisolid preparation and a preparation method thereof. The preparation method comprises the following steps: with high-purity carbazochrome sodium sulfonate with the purity above 99.80 percent as an active ingredient, adding a medical matrix to prepare one of suppository, ointment and gel; wherein every10g of the suppository contains 20-80mg of carbazochrome sodium sulfonate; the ointment per 10g contains 40-80mg of the carbazochrome sodium sulfonate; every 5g of the gel contains 40-80mg of the carbazochrome sodium sulfonate. According to the carbazochrome sodium sulfonate semisolid preparation and the preparation method disclosed by the invention, the purity of the carbazochrome sodium sulfonate serving as the active ingredient is above 99.80 percent and by-products are controlled to be below 0.2 percent; when the carbazochrome sodium sulfonate semisolid preparation is used, the adverse reaction incidence in the medication process can be lowered and the medication safety can be improved; meanwhile, the prepared carbazochrome sodium sulfonate semisolid preparation can be delivered by virtue of body cavities so that the high-purity carbazochrome sodium sulfonate is capable of improving the medication safety while high bioavailability of a product is ensured.
Owner:贵州健瑞安药业有限公司

Preparation technology of carbazochrome sodium sulfonate for injection

The invention discloses a preparation technology of carbazochrome sodium sulfonate for injection, solving the shortcoming of the conventional preparation technology of carbazochrome sodium sulfonate injection. The preparation technology is low in cost, high in yield, and high in stability of the quality of carbazochrome sodium sulfonate. The preparation technology comprises the following steps of: (1) adding mannitol to about 25% of infusion water based on preparation amount, heating to completely dissolve, then adding 0.2% (W/V) medical carbon based on the preparation amount, boiling for 30 minutes, and decarburizing and filtering; (2) getting 30% of injection water based on the preparation amount, cooling to reach temperature less than 40 DEG C, adding absolute carbazochrome sodium sulfonate, stirring to completely dissolve, and adding the solution to the mannitol filtrate to uniformly mix; and (3) adjusting the pH (Potential of Hydrogen) of the liquid medicine into 5.5 to 6.0 by 10% of sodium hydroxide solution, adding the injection water until reaching the preparation amount, stirring uniformly, rechecking the pH between 5.5 and 6.0, sequentially filtering by microfiltration membranes of 0.45 microns and 0.22 microns, delivering semi-finished products for inspection, and filling after passing the inspection. By adopting the preparation technology, the market competitiveness of the carbazochrome sodium sulfonate is improved, the convenience is provided for market sales of the carbazochrome sodium sulfonate, and the preparation technology is worthy for popularization.
Owner:HENAN FUREN HUAIQINGTANG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products