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Carbazochrome sodium sulfonate and preparing method thereof

A technology of sodium carboxysulfonate and sodium bisulfite, applied in the direction of organic chemistry and the like, can solve the problems of unsuitable industrial production, complicated operation, many steps, etc., and achieve the effects of excellent physical and chemical properties, short reaction steps, and mild reaction conditions.

Active Publication Date: 2015-09-23
成都天台山制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The article "Revised Structure of the Adrenochrome Sulfonate, Ac-17and Ac-44" published by Mitsutaka Kawazu et al. provides a method for synthesizing sodium carbosulfonate. The method uses adrenaline as a raw material and undergoes cyclization under the action of silver oxide to generate Adrenaline red, adrenaline red and semicarbazide are substituted to form carbacide, and carbacide reacts with a weakly alkaline reducing agent to generate carbacin sodium. This synthetic method has many steps, and more expensive reagents are used in the reaction. The operation is also complicated, so it is not suitable for industrial production
[0008] A synthetic method provided by Zhu Baoquan et al. ("New Drug Synthesis Handbook", pp. 181-184), which uses adrenaline as a starting material, undergoes electrolytic oxidation to generate adrenochrome, and then substitutes with semicarbazide to generate carbac Carbachol reacts with a weakly alkaline reducing agent to generate carbachol sulfonate. The synthesis method also has many steps. Electrolytic oxidation is used in the reaction, and the operation is also complicated, so it is also not suitable for industrial production.

Method used

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  • Carbazochrome sodium sulfonate and preparing method thereof

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Embodiment 1

[0064] A) raw material dissolution reaction, 50 parts of purified water, 10 parts of epinephrine color hydrazone, 8 parts of sodium bisulfite and 1 part of ascorbic acid that will be weighed in parts by weight are put into reaction tank, stir while heating, when heating temperature is At 60°C, the solid matter was completely dissolved, and the reaction was continued at 60°C for 30 minutes to obtain a reaction solution;

[0065] B) decolorization and separation, in the reaction solution obtained by step A), add a decolorant, i.e. medicinal activated carbon, the addition of medicinal activated carbon is 0.15% of the weight of the reaction solution, maintain the temperature at 60° C. and stir and decolorize for 60 minutes, and the decolorization is completed Afterwards, spin filter, wash the residue with purified water, spin dry, and combine the spin filtrate to obtain the liquid to be crystallized;

[0066] C) crystallization, the pH of the solution to be crystallized obtained i...

Embodiment 2

[0069] A) raw material dissolution reaction, 80 parts by weight of purified water, 12 parts of adrenaline color hydrazone, 10 parts of sodium bisulfite and 5 parts of ascorbic acid are dropped into the reaction tank, stirred while heating, when the heating temperature is At 70°C, the solid matter was completely dissolved, and the reaction was continued at 70°C for 60 minutes to obtain a reaction solution;

[0070] B) decolorization and separation, in the reaction solution obtained by step A), add a decolorant, i.e. medicinal activated carbon, the addition of medicinal activated carbon is 0.16% of the weight of the reaction solution, maintain the temperature at 70° C. and stir and decolorize for 60 minutes, and the decolorization is completed Afterwards, spin filter, wash the residue with purified water, spin dry, and combine the spin filtrate to obtain the liquid to be crystallized;

[0071] C) crystallization, the pH of the solution to be crystallized obtained in step B) is a...

Embodiment 3

[0074] A) raw material dissolution reaction, 100 parts of purified water, 15 parts of adrenaline color hydrazone, 12 parts of sodium bisulfite and 3 parts of ascorbic acid that will be weighed in parts by weight are dropped into the reaction tank, stirred while heating, when the heating temperature is At 90°C, the solid matter was completely dissolved, and the reaction was continued at 90°C for 20 minutes to obtain a reaction solution;

[0075] B) decolorization and separation, in the reaction liquid that is obtained by step A), add decolorant namely medicinal active carbon, the add-on of medicinal active carbon is 0.155% of the weight of reaction liquid, maintain at 90 ℃ of temperature and stir decolorization 40min, decolorization completes Afterwards, spin filter, wash the residue with purified water, spin dry, and combine the spin filtrate to obtain the liquid to be crystallized;

[0076] C) crystallization, the pH of the solution to be crystallized obtained in step B) is a...

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Abstract

The invention relates to carbazochrome sodium sulfonate and a preparing method thereof. Particularly, on one aspect, the invention relates to carbazochrome sodium sulfonate which is prepared by the method with the following steps: raw material dissolving reaction, decoloration separation, crystallization and refining. The invention provides the carbazochrome sodium sulfonate with excellent properties, which can be used for bleeding of urinary systems, upper gastrointestinal tracts, respiratory tracts and obstetrical and gynecological diseases. The carbazochrome sodium sulfonate has an obvious effect for bleeding treatment of the urinary systems, can also be used for bleeding of wounds and operations. The carbazochrome sodium sulfonate prepared by the method has excellent physicochemical properties.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a hemostatic drug, in particular to a sodium carbosulfonate with excellent properties. The present invention also relates to the preparation method of the sodium carbosulfonate. The carbosulfonate sodium can be used for urinary system, upper digestive tract, respiratory tract and obstetrics and gynecology diseases bleeding. Sodium carbosulfonate has a significant effect on urinary system bleeding, and it can also be used for trauma and surgical bleeding. The sodium carbosulfonate prepared by the invention has excellent physical and chemical properties. Background technique [0002] Sodium carbosulfonate, also known as Xinanluoxue, its chemical name is: 1-methyl-6-oxo-2,3,5,6-tetrahydroindole-5-semicarbazone-2-sodium sulfonate Salt trihydrate, English name is Carbazochrome Sodium Sulfonate, molecular formula: C10H11N4O5SNa 3H2O, molecular weight: 376.32, structural formula as ...

Claims

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Application Information

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IPC IPC(8): C07D209/30
CPCC07D209/30
Inventor 方专陈娟吴国庆王敬江威赵东明
Owner 成都天台山制药股份有限公司
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