Special ultrafine carbazochrome sodium sulfonate powder freeze-dried preparation and preparation method thereof

A technology of ultrafine powder and sodium carbosulfonate, which is applied in the field of medicine, can solve the problems of large toxic and side effects, small specific surface area, poor stability, etc., and achieve the effect of improving utilization rate, large specific surface area and high stability

Inactive Publication Date: 2014-11-05
杭州长典老一元健康管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The existing sodium carbosulfonate has the disadvantages of poor stability, low purity, many impurities,

Method used

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  • Special ultrafine carbazochrome sodium sulfonate powder freeze-dried preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Dissolve 1000 grams of Kabakol in 3500 grams of water, add 350 grams of sodium bisulfite and 40 grams of vitamin C to react, stir during the reaction, the reaction temperature is 70 ° C, and the reaction time is 50 minutes to obtain a mixed solution. 7.5 g of activated carbon was added to the mixed solution for decolorization, the temperature was maintained at 70° C. for stirring and decolorization for 60 minutes, and after decolorization, it was filtered to obtain a filtrate. Use 5% sodium hydroxide solution to adjust the pH value of the filtrate to 5, lower the temperature of the filtrate to 0°C and let it stand for 8 hours, a large amount of crystals are precipitated, the crystals are separated by filtration, the crystals are washed with water and acetone successively, and then The crystals were vacuum-dried, the vacuum degree of vacuum drying was -0.08Mpa, the drying temperature was 80°C, and the drying time was 6 hours to obtain sodium carbosulfonate with a purity o...

Embodiment 2

[0030] Dissolve 1000 grams of Kabakol in 7000 grams of water, add 800 grams of sodium bisulfite and 200 grams of vitamin C to react, stir during the reaction, the reaction temperature is 75 ° C, and the reaction time is 40 minutes to obtain a mixed solution. 18 grams of activated carbon was added to the mixed solution for decolorization, and the temperature was maintained at 75° C. for stirring and decolorization for 50 minutes. After decolorization, the mixture was filtered to obtain a filtrate. Use 10% sodium hydroxide solution to adjust the pH value of the filtrate to 7, lower the temperature of the filtrate to 2°C and let it stand for 12 hours, a large amount of crystals are precipitated, the crystals are separated by filtration, the crystals are washed with water and acetone successively, and then The crystals were vacuum-dried, the vacuum degree of vacuum drying was -0.09Mpa, the drying temperature was 70°C, and the drying time was 8 hours to obtain sodium carbosulfonate ...

Embodiment 3

[0034] Dissolve 1000 grams of carbacil in 10 kilograms of water, add 1200 grams of sodium bisulfite and 500 grams of vitamin C to react, stir during the reaction, the reaction temperature is 80 ° C, and the reaction time is 30 minutes to obtain a mixed solution. Add 32 grams of activated carbon to the mixed solution for decolorization, maintain the temperature of 80° C. for stirring and decolorization for 40 minutes, and filter after decolorization to obtain a filtrate. Use 20% sodium hydroxide solution to adjust the pH value of the filtrate to 8, lower the temperature of the filtrate to 5°C and let it stand for 16 hours, a large number of crystals are precipitated, the crystals are separated by filtration, the crystals are washed with water and acetone successively, and then The crystals were vacuum-dried, the vacuum degree of vacuum drying was -0.095Mpa, the drying temperature was 60°C, and the drying time was 10 hours to obtain sodium carbosulfonate with a purity of 99.6%. ...

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Abstract

The invention discloses a special ultrafine carbazochrome sodium sulfonate powder freeze-dried preparation and a preparation method thereof. The method comprises the following steps: step 1, dissolving carbazochrome sodium sulfonate in water, adding sodium bisulfite and carrying out a reaction so as to prepare a mixed liquor; step 2, adding a decolorant into the mixed liquor for decoloring and carrying out filtering so as to obtain a filtrate; step 3, adjusting the pH value of the filtrate by using sodium hydroxide, carrying out cooling, allowing a crystal to be precipitated and then successively carrying out filtering, washing and vacuum drying so as to obtain carbazochrome sodium sulfonate; and step 4, carrying out air jet pulverization on dried carbazochrome sodium sulfonate, dissolving special ultrafine powder of carbazochrome sodium sulfonate in injection water, carrying out low-temperature pre-freezing, then carrying out low-temperature pressure-reduced vacuum drying and finally, carrying out high temperature drying so as to prepare the special ultrafine carbazochrome sodium sulfonate powder freeze-dried preparation. The special ultrafine carbazochrome sodium sulfonate powder freeze-dried preparation prepared in the invention has the advantages of high stability, high purity, a few impurities, a small size, a great specific surface area, good dissolvability, small toxic and side effects, uneasy incurrence of irritability, etc.

Description

technical field [0001] The invention relates to a special ultrafine powder freeze-dried preparation of sodium carbosulfonate and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Sodium carbosulfonate, its chemical name is: 1-methyl-6-oxo-2,3,5,6-tetrahydroindole-5-semicarbazone-2-sulfonic acid sodium salt trihydrate, English Named Carbazochrome Sodium Sulfonate, molecular formula: C10H11N4O5SNa 3H2O, molecular weight: 376.32, structural formula as follows: [0003] [0004] Sodium carbosulfonate was first developed by Japan Tanabe Pharmaceutical Co., Ltd., and has been recorded by the Japanese Ministry of Health and Welfare as the twelfth edition of the Japanese Pharmacopoeia (1992). Sodium carbosulfonate is a new generation of vascular hemostatic drug and a vascular strengthening agent with great clinical value. It is a derivative of carbacyl, which introduces sodium sulfonate groups into its molecular structure,...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K31/404
Inventor 傅苗青李凤生陈宇东厉达中周白水
Owner 杭州长典老一元健康管理有限公司
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