Hemostatic injection of carbazochrome sodium sulfonate and method for preparing the same

The technology of sodium carboxysulfonate and sodium carboxylate is applied in the field of hemostatic sodium carboxylate injection and its preparation, and can solve problems such as adverse consequences, influence on treatment effect, and decrease of sodium carboxylate content.

Active Publication Date: 2006-09-06
CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This may cause serious adverse consequences for clinical application
Its two, add activated carbon for needles when preparing the medicinal solution containing sodium carbosulfonate, and the activated carbon adsorption time is as long as 30min and then filter and decarbonize. Decreased sodium levels, affecting therapeutic efficacy

Method used

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  • Hemostatic injection of carbazochrome sodium sulfonate and method for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Weigh raw materials according to the following formula

[0010] Sodium carbosulfate 2g

[0011] Potassium chloride 9g

[0012] Acetamide 0.25g

[0013] 1N hydrochloric acid 0.14mg

[0014] Water for injection 1000ml

[0015] Take potassium chloride, add 600ml of water for injection, add 0.8g of activated carbon and boil for 15min, filter and decarbonize, add 200ml of water for injection, add sodium carbosulfate and acetamide, adjust the pH value to 4.5-6.5 with 1N hydrochloric acid, and replenish 200ml of water , After the solution passes through the carbon layer, it is filtered through a 0.22um microporous membrane and then filled into an infusion bottle, ventilated with nitrogen, crimped and sterilized.

Embodiment 2

[0017] Weigh raw materials according to the following formula

[0018] Sodium carbosulfonate 0.18g

[0019] Sodium chloride 9g

[0020] Sodium citrate 0.125g

[0021] 1N hydrochloric acid 0.12mg

[0022] Water for injection 1000ml

[0023] Weigh sodium chloride, add 700ml of water for injection, add 0.7g of activated carbon and boil for 15 minutes, filter and decarbonize, add 100ml of water for injection, add sodium carbosulfonate and sodium citrate, adjust the pH value to 4.5-6.5 with 1N hydrochloric acid , replenish 200ml of water, pass the solution through the carbon layer, filter it through a 0.22um microporous membrane, fill it, pass nitrogen, crimp the cap, and sterilize.

Embodiment 3

[0025] Weigh raw materials according to the following formula

[0026] Sodium carbosulfonate 0.8g

[0027] Sodium chloride 9g

[0028] Sodium citrate 0.1g

[0029] 1N hydrochloric acid 0.06mg

[0030] Water for injection 1000ml

[0031] The preparation process is the same as in Example 2.

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PUM

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Abstract

Disclosed is a hemostatic injection of carbazochrome sodium sulfonate and method for preparation, wherein the injection comprises carbazochrome sodium sulfonate 0.005-0.5 wt%, the optimum content being 0.008-0.2%, auxiliary solvent 0.001-0.5 wt%, the optimum content being 0.002-0.1%, osmoregulation agent 0.8-15 wt%, and water for injection 84.0-99.1%. The preparing process consists of boiling, filtering, removing charcoal, adjusting pH to 4.5-6.5, passing soup through a charcoal layer, loading into transfusion bottles, venting nitrogen, rolling the caps, and sterilizing.

Description

technical field [0001] The invention relates to an injection of the hemostatic drug carbosulfonate and a preparation method thereof. Background technique [0002] Carbazochrome sodium is a new generation of epinephrine hydrazone derivative hemostatic drug, it can increase the elasticity of capillaries, reduce the permeability of capillaries, promote the activity of thrombin and the dissolution of fibrinogen, and play a hemostatic effect . Clinically, it can be used for urinary system, upper gastrointestinal tract, respiratory tract, obstetrics and gynecology diseases, trauma and surgical hemostasis. Sodium carbosulfonate can be taken orally or intravenously. For example, CN200410023441.X discloses a sodium carbosulfonate infusion and a preparation method thereof. In CN200410023441.X, sodium carbosulfonate infusion is prepared with sodium carbosulfonate, antioxidant, osmotic pressure regulator and water for injection. But still there are deficienc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/404A61K9/08A61P7/04
Inventor 周桂荣
Owner CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD
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