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Carbazochrome sodium sulfonate oral disintegrating tablets and preparation method thereof

An orally disintegrating tablet and sodium carboxylate technology, applied in the field of pharmaceutical preparations, can solve the problems such as no oral disintegrating tablet on the market, no research report, etc., and achieve stable and easy-to-control formulation quality, high bioavailability, and ease of use. accepted effect

Inactive Publication Date: 2010-08-11
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The types of preparations that have been marketed for sodium carbosulfonate mainly include ordinary tablets, capsules, powders, granules, injections, and powder injections for injections. At present, there are no orally disintegrating tablets on the market, and no relevant research reports have been seen.

Method used

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  • Carbazochrome sodium sulfonate oral disintegrating tablets and preparation method thereof
  • Carbazochrome sodium sulfonate oral disintegrating tablets and preparation method thereof
  • Carbazochrome sodium sulfonate oral disintegrating tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] prescription

[0044]

[0045] The preparation method is to crush all the components in the prescription except sodium carbosulfonate into fine powder with a fineness of more than 100 mesh; dry the starch at 100-105°C to keep the water content below 8%; Sodium sulfonate and dry starch are mixed, pulverized, and passed through an 80-mesh sieve; then mixed with prescription quantities of mannitol, microcrystalline cellulose, hydroxypropyl methylcellulose and menthol and 1 / 2 prescription quantities of crospovidone Mix and pass through a 80-mesh sieve; then add an appropriate amount of ethanol water solution with a volume fraction of 60% to make soft materials, granulate with a 24-mesh sieve, dry at 60±5°C, pass the dry granules through a 24-mesh sieve for granulation; then add the remaining Crospovidone and the prescribed amount of magnesium stearate were mixed evenly and tabletted to make 1000 orally disintegrating tablets of sodium carbosulfonate, each containing 10 ...

Embodiment 2

[0048] prescription

[0049]

[0050] The preparation method is to crush all the components in the prescription except sodium carbosulfonate into fine powder with a fineness of more than 100 mesh; dry the starch at 100-105°C to keep the water content below 8%; Sodium sulfonate and dry starch are mixed, pulverized, and passed through an 80-mesh sieve; then cross-linked with mannitol, microcrystalline cellulose, citric acid, hydroxypropyl methylcellulose and menthol and 1 / 2 of the prescription amount Mix povidone and pass through a 80-mesh sieve; then add an appropriate amount of ethanol aqueous solution with a volume fraction of 60% to make soft materials, granulate with a 24-mesh sieve, dry at 60±5°C, and pass the dry granules through a 24-mesh sieve for granulation; Add the sodium bicarbonate and magnesium stearate of remaining crospovidone and prescription quantity in, mix, tabletting, make 1000 tablets of orally disintegrating sodium carbosulfonate altogether, each cont...

Embodiment 3

[0053] prescription

[0054]

[0055] The preparation method is to crush all the components in the prescription except sodium carbosulfonate into fine powder with a fineness of more than 100 mesh; dry the starch at 100-105°C to keep the water content below 8%; Sodium sulfonate and dry starch are mixed, pulverized, and passed through an 80-mesh sieve; then mixed with prescription quantities of mannitol, microcrystalline cellulose, hydroxypropyl methylcellulose and menthol and 1 / 2 prescription quantities of crospovidone Mix and pass through a 80-mesh sieve; then add an appropriate amount of ethanol water solution with a volume fraction of 60% to make soft materials, granulate with a 24-mesh sieve, dry at 60±5°C, pass the dry granules through a 24-mesh sieve for granulation; then add the remaining Cross-linked povidone, magnesium stearate and aspartame in the prescribed amount were mixed evenly, and tabletted to make 1000 orally disintegrating tablets of sodium carbosulfonate...

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Abstract

The invention discloses carbazochrome sodium sulfonate oral disintegrating tablets and a preparation method thereof. The carbazochrome sodium sulfonate oral disintegrating tablets are prepared from the following components in percentage by mass: 1-15% of carbazochrome sodium sulfonate, 50-90% of filler, 5-40% of disintegrant, 1-8% of adhesive, 0.1-5% of lubricant and 0.1-5% of flavoring agent. The oral disintegrating tablets have the advantages of smooth surface, attractive appearance, moderate hardness, quick absorption, quick effect taking, small liver first-pass effect, high bioavailability, little irritation to the gastrointestinal tract, favorable mouthfeel and convenient taking, can quickly disintegrate in the oral cavity without water, is particularly suitable for aged people, children, patients in bed or with dysphagia, and especially for bleeding patients inconvenient to drink water during or after operations. The oral disintegrating tablets are prepared in a wet-method pelletizing tabletting way. The preparation method has the advantages of simple production technology, stable and easily-controlled preparation quality, and low cost, and is suitable for industrial large-scale production.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to an orally disintegrating tablet of sodium carbosulfonate, and also relates to a preparation method of the orally disintegrating tablet. Background technique [0002] Tablet has the advantages of stable quality, accurate dosage, convenient taking and carrying, high degree of production mechanization, and low production cost. It is one of the most commonly used pharmaceutical dosage forms at present. But at the same time, due to its slow disintegration, low bioavailability, and difficulty in swallowing for some patients, its application is limited to a certain extent. In recent years, new types of tablets such as orally disintegrating tablets, dispersible tablets and sublingual tablets have emerged. Orally disintegrating tablet is a tablet that can disintegrate or dissolve quickly without water in the oral cavity. Convenient and other advantages, especially suitable for the elderly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/404A61P7/04
Inventor 罗永煌聂延君田朋鑫刘艳玲罗雷雷曙光陈君乔彦茹
Owner SOUTHWEST UNIV
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