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Carbazochrome sodium sulfoate dripping pill and its preparing method

A technology for sodium carboxysulfonate dropping pills and sodium carboxylate, which is applied in the directions of pill delivery, blood diseases, extracellular fluid diseases, etc., can solve the problems affecting the therapeutic effect of sodium carboxylate, low dissolution rate and rate, and dosage of excipients. Large proportion and other problems, to achieve the effects of convenience in carrying and taking, improvement in dissolution rate and dissolution rate, and reduction in the amount of excipients

Inactive Publication Date: 2005-01-12
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Sodium carbosulfonate is odorless, easily soluble in hot water, slightly soluble in water, the disintegration time of the tablet is long, the dissolution rate and dissolution rate are low, the absorption is poor, the bioavailability is low, and the proportion of auxiliary materials is large. Children, the elderly People, bedridden patients and patients with dysphagia are inconvenient to take and have poor compliance, which affects the therapeutic effect of carbosulfonate sodium

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0051] prescription:

[0052] Sodium carbosulfonate 5g

[0053] Macrogol 6000 15g

[0054] Makes 1000 capsules

[0055] Preparation method: Take the fine powder of sodium carbosulfonate that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone as a coolant, make pellets by dropping, and dry, that is have to.

example 2

[0057] prescription:

[0058] Sodium carbosulfonate 5g

[0059] Macrogol 4000 15g

[0060] Makes 1000 capsules

[0061] Preparation method: Take the fine powder of sodium carbosulfonate that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone as a coolant, make pellets by dropping, and dry, that is have to.

example 3

[0063] prescription:

[0064] Sodium carbosulfonate 5g

[0065] Macrogol 6000 5g

[0066] Macrogol 4000 10g

[0067] Makes 1000 capsules

[0068] Preparation method: Take the fine powder of sodium carbosulfonate that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten mixed matrix of polyethylene glycol 4000 and polyethylene glycol 6000, stir well, use simethicone oil as the coolant, drop The preparation method is to make pills, dry them, and obtain them.

[0069] 4. Example 4

[0070] prescription:

[0071] Sodium carbosulfonate 5g

[0072] Glyceryl monostearate 15g

[0073]Makes 1000 capsules

[0074] Preparation method: Take the fine powder of sodium carbosulfonate that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate base, mix well, use ice water as a coolant, make pellets by drop method, and dry to obtain .

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PUM

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Abstract

A dripping pill of carbazochrome sodium sulfonate is prepared through superfine pulverizing and conventional steps for preparing dripping pills.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to sodium carbosulfonate dripping pills and a preparation method thereof. Background technique [0002] Sodium carbosulfonate can increase the resistance of capillaries to injury, reduce the permeability of capillaries, and promote the retraction of broken capillaries to stop bleeding. [0003] After oral administration of 150 mg carbosulfonate to healthy adult males, the maximum concentration in the blood is greater than 25 mg / ml in 0.5 to 1 hour, and the half-life (t 1 / 2 ) for 1.5 hours, the drug concentration in the urine reached the highest within 0.5 to 1 hour after oral administration, and the excretion was completed in about 24 hours. Clinically as a hemostatic drug. [0004] Sodium carbosulfonate is odorless, easily soluble in hot water, slightly soluble in water, the disintegration time of the tablet is long, the dissolution rate and dissolu...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/404A61P7/04
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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