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Medicinal composition containing carbazochrome sodium sulfonate compound and preparation method thereof

A technology of sodium carbosulfonate and its composition, which is applied in the field of pharmaceutical compositions containing sodium carbosulfonate and its preparation, can solve the problems of poor stability and difficulty in long-term storage, and achieve the effect of overcoming poor stability

Active Publication Date: 2011-10-12
福建康成医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a pharmaceutical composition containing carbosulfonium compound with good stability and long storage time for the problems of poor stability and difficulty in long-term storage of the existing sodium carbosulfonate injection.

Method used

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  • Medicinal composition containing carbazochrome sodium sulfonate compound and preparation method thereof
  • Medicinal composition containing carbazochrome sodium sulfonate compound and preparation method thereof
  • Medicinal composition containing carbazochrome sodium sulfonate compound and preparation method thereof

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Effect test

Embodiment 1

[0021] 1. Formula (weight: g): sodium carbosulfate 1, mannitol 0.1, dextran 2 and sodium hydroxide 0.5.

[0022] 2. Preparation method:

[0023] 1) Add the prescribed amount of sodium carbosulfonate, mannitol and dextran into an appropriate amount of water for injection, and stir until completely dissolved to obtain solution A;

[0024] 2) adding sodium hydroxide into an appropriate amount of water for injection to dissolve, then adding the sodium hydroxide solution into solution A, stirring evenly, so that the pH value of the mixed solution is 5, and obtaining solution B;

[0025] 3) Add activated carbon with a prepared volume of 0.5% to solution B, boil for 30 minutes, filter and decarbonize, collect the filtrate, and then sterilize and filter with a 0.2 μm microporous membrane to collect filtrate C;

[0026] 4) The filtrate C is freeze-dried to make a powdery pharmaceutical composition.

Embodiment 2

[0028] 1. Formula (weight: g): sodium carbosulfonate 1, mannitol 1, dextran 8 and sodium hydroxide 2.

[0029] 2. Preparation method:

[0030] 1) Add the prescribed amount of sodium carbosulfonate, mannitol and dextran into an appropriate amount of water for injection, and stir until completely dissolved to obtain solution A;

[0031] 2) adding sodium hydroxide into an appropriate amount of water for injection to dissolve, then adding the sodium hydroxide solution into solution A, stirring evenly, so that the pH of the mixed solution is 6, and obtaining solution B;

[0032] 3) Add activated carbon with a prepared volume of 0.5% to solution B, boil for 30 minutes, filter and decarbonize, collect the filtrate, and then sterilize and filter with a 0.2 μm microporous membrane to collect filtrate C;

[0033] 4) The filtrate C is freeze-dried to make a powdery pharmaceutical composition.

Embodiment 3

[0035] 1. Formula (weight: g): sodium carbosulfonate 1, mannitol 0.6, dextran 6 and sodium hydroxide 1.

[0036] 2. Preparation method:

[0037] 1) Add the prescribed amount of sodium carbosulfonate, mannitol and dextran into an appropriate amount of water for injection, and stir until completely dissolved to obtain solution A;

[0038] 2) Dissolve sodium hydroxide in an appropriate amount of water for injection, then add the sodium hydroxide solution into solution A, stir evenly, make the pH of the mixed solution 5.5, and obtain solution B;

[0039] 3) Add activated carbon with a prepared volume of 0.5% to solution B, boil for 30 minutes, filter and decarbonize, collect the filtrate, and then sterilize and filter with a 0.2 μm microporous membrane to collect filtrate C;

[0040] 4) The filtrate C is freeze-dried to make a powdery pharmaceutical composition.

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Abstract

The invention provides a medicinal composition containing carbazochrome sodium sulfonate compound and a preparation method thereof. The medicinal composition containing carbazochrome sodium sulfonate compound consists of carbazochrome sodium sulfonate, mannitol, dextran and sodium hydroxide. The medicinal composition containing carbazochrome sodium sulfonate compound can solves the problems of low stability, low solubility and the like of the conventional carbazochrome sodium sulfonate powder injection and is more suitable for use in clinic.

Description

technical field [0001] The present invention relates to the field of pharmaceutical preparations, in particular to a pharmaceutical composition containing sodium carbosulfonate compound and a preparation method thereof. Background technique [0002] Carbazochrome Sodium Sulfonate is a chemical derivative of Adrenochrome, its chemical name is: 1-methyl-6-oxo-2,3,5,6-tetrahydroindoline-5 -Sodium semicarbazone-2-sulfonate, CAS: 51460-26-5, its structure is as shown in formula (I): [0003] Formula (I) [0004] It can reduce the permeability of capillaries and enhance the retraction of broken ends of capillaries. It is often used for various bleedings caused by increased capillary permeability. [0005] Studies have shown that the stability of sodium carbosulfonate injection is poor, and long-term storage is susceptible to changes in physical and chemical properties due to the influence of oxygen, temperature, and light. Due to its poor solubility, long-term storage will lea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/404A61K47/36A61P7/04
Inventor 罗诚
Owner 福建康成医药有限公司
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