Preparation method of curcumin-containing medical dressing based on silk fibroin

A technology containing curcumin medicine and silk fibroin, which is applied in medical science, absorbent pads, bandages, etc., can solve the problems of low slow release rate of curcumin, difficulty in effectively preventing bacterial penetration, and unsuitability for clinical wound repair, etc., to achieve Excellent light transmittance, good air and moisture permeability, excellent anti-fine effect

Pending Publication Date: 2019-11-15
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The mixed solution of curcumin and silk fibroin was prepared into a three-dimensional porous scaffold for wound dressing, but the slow release rate of curcumin in the prepared material was too low, and its porous structure was difficult to effectively prevent bacteria from penetrating, so it was not suitable for Clinical wound repair ( Curcumin-loadedsilk fibroin e-gel scaffolds for wound healing applications[J].MaterialsTechnology,2018,33(2):1-12.)

Method used

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  • Preparation method of curcumin-containing medical dressing based on silk fibroin
  • Preparation method of curcumin-containing medical dressing based on silk fibroin
  • Preparation method of curcumin-containing medical dressing based on silk fibroin

Examples

Experimental program
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Effect test

Embodiment 1

[0039] (1) Weigh 0.5 g of curcumin and dissolve it in 100 mL of absolute ethanol, stir it overnight with magnetic force to fully dissolve it, and store it in the dark at 4°C for later use.

[0040] (2) Weigh 20g of silkworm cocoon, cut the cocoon shell into a spiral shape, add boiling 1000mL 0.5% Na 2 CO 3 Boil in the solution for 30min. The silkworm cocoons were taken out and scrubbed repeatedly with deionized water until there was no greasy feeling, boiled twice and scrubbed repeatedly, and dried at room temperature to obtain fibrous silk fibroin.

[0041] (3) Prepare CaCl with a molar ratio of 1:2:8 2 、CH 3 CH 2 OH, H 2 O ternary solution 100mL, add 10g silk fibroin into the ternary solution, place in a water bath at 70°C and stir continuously with a glass rod until the fibrous silk fibroin is completely dissolved.

[0042] (4) Pour the above-mentioned cooled solution into a clean dialysis bag, squeeze out the air in the dialysis bag, seal both ends, and dialyze in de...

Embodiment 2

[0072] The dressing of Example 2 was prepared with reference to Example 1, wherein the glutaraldehyde solution added in step 7 was 0 μL, and the glycerin solution was 12 μL. Investigate the sustained-release situation of curcumin in the prepared dressing, the results are shown in Table 3 below.

[0073] The slow-release situation of the dressing curcumin prepared by the embodiment 2 of table 3

[0074]

Embodiment 3

[0076] The dressing of Example 3 was prepared with reference to Example 1, wherein 13 μL of glutaraldehyde solution and 0 μL of glycerin solution were added in step 7. Investigate the sustained-release situation of curcumin in the prepared dressing, and the results are shown in Table 4 below.

[0077] The slow-release situation of the dressing curcumin that table 4 embodiment 3 prepares

[0078]

[0079] The medical dressings prepared in Examples 2-3 of the present invention have excellent light transmittance, can withstand a certain pressure, and can be closely attached to non-planar surfaces; the surfaces of the prepared dressings all present a spherical structure, and the preparation method does not destroy silk fibroin structure, and has higher thermal stability than silk fibroin film; the prepared dressing has good air and moisture permeability, which can provide a suitable environment for the wound area; the release rate of curcumin in the prepared dressing sample is ...

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Abstract

The invention provides a preparation method of a curcumin-containing medical dressing based on silk fibroin. According to the invention, silk cocoon is degummed, dried, dissolved, dialyzed, and concentrated to produce a silk fibroin aqueous solution, the silk fibroin aqueous solution is then mixed with glutaraldehyde, glycerin, and a curcumin ethanol solution to prepare the curcumin-containing medical dressing based on silk fibroin. The dressing prepared by the method effectively avoids the defect of easy penetration of bacteria in high porosity materials, and the prepared dressing has good air permeability and moisture permeability, which can provide the suitable environment for a wound area; the slow-release rate of curcumin can be adjusted by changing a slow-release medium; the producthas good antibacterial properties, the antibacterial rate against Staphylococcus aureus is higher than 70% within 12 hours, and is used for wound repair and is more conducive to cell proliferation andadhesion than a pure silk fibroin film.

Description

technical field [0001] The invention belongs to the technical field of medical dressings, and in particular relates to a method for preparing a curcumin-containing medical dressing based on silk fibroin. Background technique [0002] As the largest organ in the human body, the skin can effectively prevent the loss of water, electrolytes and plasma proteins, resist the invasion of bacteria, prevent the entry of poisons, resist mechanical damage, and resist the harm of ultraviolet radiation to the human body when the skin is in contact with the external environment. In addition, the skin also has physiological functions such as sensation, secretion, excretion and temperature regulation. In daily life, it is inevitable to cause skin defects due to diseases such as skin ulcers caused by trauma, burns, scalds and human lesions. In the process of wound repair, dressing is an essential medical material, which is used to protect the wound and promote its healing. As a wound coveri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/42A61L15/44A61L15/46A61L15/20
CPCA61L15/20A61L15/32A61L15/425A61L15/44A61L15/46A61L2300/216A61L2300/404A61L2300/412A61L2300/604C08L89/00
Inventor 张小宁陈珍玉包红梁健威徐水成国涛
Owner SOUTHWEST UNIV
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