Freeze-drying method of pseudo-ginseng total saponin freeze-dried injection powder with filling amount more than 500 mg
A technology of total Panax notoginseng saponins and a drying method, which is applied in the field of freeze drying of Panax notoginseng total saponins freeze-dried powder injection, can solve the problems of high production energy consumption, long turnover time, no freezing method and conditions are provided, and can achieve energy efficiency. Consumption saving, efficiency improvement, significant economic and social benefits
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Embodiment 1
[0063] Example 1: 500 mg loading capacity of Panax notoginseng freeze-dried powder injection
[0064] Method: Dissolve Panax notoginseng saponins with water for injection, so that the concentration of Panax notoginseng saponins in the solution is 10.0% (g / ml), and then subpackage according to 500mg filling volume, fill each bottle with 5ml, and put it in a freeze dryer:
[0065] 1) Pre-freezing and heat balance: start the compressor, set the temperature in the freeze dryer to -10°C within 0.75 hours, and maintain it for 0.5 hours;
[0066] 2) Freezing and system balance: After the end of heat release, set the temperature in the freeze dryer to drop below -30°C within 0.75 hours, and drop the temperature inside the freeze dryer to -30°C within 0.75 hours. Below 45°C; control the internal pressure of the freeze dryer to below 10Pa and maintain it for 1.5h;
[0067] 3) In the early stage of sublimation: set the temperature inside the freeze dryer to -4°C, and keep the vacuum bel...
Embodiment 2
[0072] Example 2: 600 mg loading capacity of Panax notoginseng freeze-dried powder injection
[0073] Method: Dissolve Panax notoginseng saponins with water for injection, so that the concentration of Panax notoginseng saponins in the solution is 12.0% (g / ml), divide into 600mg fillings, fill each bottle with 5ml, and place in a freeze dryer.
[0074] 1) Pre-freezing and heat balance: start the compressor, set it within 0.25 hours to drop the temperature inside the freeze dryer to -10°C, and maintain it for 1 hour;
[0075] 2) Freezing and system balance: After the end of heat release, set the temperature in the freeze dryer to drop below -30°C within 0.25 hours, and after the temperature reaches -30°C, drop the temperature inside the freeze dryer to -45°C within 0.5 hours Below ℃; control the freeze dryer to below 10Pa and maintain it for 1h;
[0076] 3) In the early stage of sublimation: set the temperature inside the freeze dryer to -4°C, and keep the vacuum below 10Pa, an...
Embodiment 3
[0081] Example 3: 700 mg loading capacity of Panax notoginseng freeze-dried powder injection
[0082] Method: Dissolve Panax notoginseng saponins with water for injection, so that the concentration of Panax notoginseng saponins in the solution is 14.0% (g / ml), divide into 700 mg, fill each bottle with 5 ml, and place in a freeze dryer.
[0083] 1) Pre-freezing and heat balance: start the compressor, set the temperature in the freeze dryer to -10°C within 0.5h, and maintain it for 0.75h;
[0084] 2) Freezing and system balance: After the end of heat release, set the temperature in the freeze dryer to drop below -30°C within 0.3 hours, and after the temperature reaches -30°C, drop the temperature inside the freeze dryer to -45°C within 1 hour below; control the pressure in the freeze dryer to below 10Pa and maintain it for 1.3h;
[0085] 3) In the early stage of sublimation: set the temperature inside the freeze dryer to -4°C, and keep the vacuum below 10Pa, and keep it warm fo...
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