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Magnesium iso-glycyrrhetate gel and its preparing method and use

A technology of magnesium glycyrrhizinate gel and magnesium isoglycyrrhizinate, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, drug delivery and other directions to achieve the effects of good effect, no greasy feeling and strong adhesion

Active Publication Date: 2005-05-18
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, magnesium isoglycyrrhizinate only has its injection in development for the treatment of hepatitis, and there is no report on the development of its external preparation

Method used

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  • Magnesium iso-glycyrrhetate gel and its preparing method and use
  • Magnesium iso-glycyrrhetate gel and its preparing method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 5

[0059] Embodiment 5: in vitro skin penetration test

[0060] The improved Franz osmotic diffusion device is used. Take a healthy rat with a body weight of 180±20g, depilate it with 8% sodium sulfide immediately after execution, shave its abdominal hair, peel off its abdominal skin, and remove its subcutaneous fat, rinse it with pure water, and then rinse it several times with normal saline. The filter paper absorbs the moisture attached to the skin. The skin is then positioned between the releasing and receiving cisterns with the stratum corneum facing upwards. Accurately take by weighing embodiment 1,2,3,4 gained gel sample m 0 (about 0.5g) is filled in the release pool (in close contact with the stratum corneum of the skin), and the receiving pool is 17ml, which is filled with the receiving solution, which is physiological saline. 37°C constant temperature water bath, rotating speed 200rpm. Samples were taken at 1, 2, 4, 8, 12, and 24 hours respectively, and 10ml of rece...

Embodiment 1

[0067] Example 1 sample Example 2 sample Example 3 sample Example 4 sample

[0068] 24h cumulative release

[0069] 6.58 5.91 7.85 7.36

[0070] (%)

[0071] 24h total transdermal volume

[0072] 13.8 10.5 17.2 15.8

[0073] (%)

[0074] In the treatment of eczema and dermatitis, the drug must penetrate the stratum corneum, and the transdermal penetration of magnesium isoglycyrrhizinate is the key and difficult point. Therefore, the therapeutic effect is better if the transdermal amount is high within a certain range. In the in vitro transdermal test of the gel sample in the aforementioned animal drug efficacy test and irritation allergy test, the cumulative transdermal release amount and the total transdermal amount in 24 hours were 6.97% and 14.3% respectively. From the experimental results of samples 1 to 4 in the above examples, magnesium isoglycyrrhizinate can penetrate the skin to a certain conce...

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PUM

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Abstract

The present invention relates to the field of medicine preparation, and discloses a kind gel containing magnesium isoglycyrrhetate and its preparation process and application. The prepared gel has stable characteristic and convenient use. Animal experiment shows that the gel of the present invention can treat psoriasis, chronic eczema and dermatitis, contact dermatitis and other allergic dermatosis.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to magnesium isoglycyrrhizinate gel and its preparation method and application. technical background [0002] Glycyrrhizic acid has pharmacological effects such as anti-inflammation, anti-allergy, immune regulation, anti-biological oxidation and inhibition of mutation. Intravenous administration of diammonium glycyrrhizinate has been used clinically to treat psoriasis and dermatitis, such as eczema, which has a good effect. Oral preparations of glycyrrhizic acid, such as compound glycyrrhizin tablets (trade name Meineng), are also used clinically to treat skin diseases such as psoriasis and eczema, but these glycyrrhizic acid preparations have certain side effects, such as water and sodium retention, etc. patient medication compliance. At present, there is no product of topical application of glycyrrhizic acid on the market. [0003] Magnesium isoglycyrrhizinate is a ne...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/566A61P17/00A61P17/10A61P37/08
Inventor 程艳菊张来芳吴锡铭王佩
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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