Application of glycopeptide mixture in preparing adjuvant therapy medicaments of tumor and health food

The technology of a mixture and glycopeptide is applied in the fields of glycopeptide mixture, health food, preparation of tumor adjuvant therapy drugs, and combined preparation of biologically active polysaccharides.

Inactive Publication Date: 2009-09-30
李勇 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is still little research on the combined application of marine bioactive peptides and bioactive polysaccharides in improving the nutritional status and immune function of patients with cancer radiotherapy and chemotherapy. If the develo

Method used

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  • Application of glycopeptide mixture in preparing adjuvant therapy medicaments of tumor and health food
  • Application of glycopeptide mixture in preparing adjuvant therapy medicaments of tumor and health food
  • Application of glycopeptide mixture in preparing adjuvant therapy medicaments of tumor and health food

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Effect of Marine Collagen Peptide and Lentinan Mixture on Improving Immune Function of Tumor-bearing Mice

[0020] Sixty healthy clean-grade male ICR mice, weighing 20.0±2.0g, were provided by the Experimental Animal Center of Peking University Health Science Center. They were raised in a clean-grade animal room with an ambient temperature of 25°C and a humidity of 60%RH. After the mice were adaptively fed for 3 days, the S180 transplanted tumor model was prepared, and the experimental methods and curative effect evaluation were carried out in accordance with the guiding principles of anticancer drug research and experimental techniques. The tumor-bearing mice were randomly divided into 5 groups after weighing, namely the normal saline group, positive control group (5-fluorouracil), marine collagen peptide and lentinan mixture (hereinafter referred to as glycopeptide mixture) 0.075, 0.15, 0.45g / kgbw group , 12 mice per group. The ratio of marine collagen pep...

Embodiment 2

[0029] Example 2: Observation of improvement of nutritional status of tumor patients with radiotherapy and chemotherapy by marine collagen peptide and lentinan mixture

[0030] From 2006 to 2007, 61 patients with malignant tumors who were clinically and pathologically diagnosed and had no contraindications to radiotherapy and chemotherapy were collected as research objects, aged 30 to 66 years, including 32 males and 29 females. Among them, there were 18 cases of lung cancer, 20 cases of gastric cancer, 15 cases of esophageal cancer, and 8 cases of colon cancer. The patients were divided into a treatment group (31 cases) and a control group (30 cases) according to body weight and tumor type. The patients in the treatment group took marine collagen peptide and lentinan mixture (hereinafter referred to as glycopeptide mixture) one week before the course of radiotherapy and chemotherapy. The ratio of collagen peptide to lentinan is 20 to 1) 10g / time, 2 times / day, orally, and the ...

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Abstract

The invention relates to a glycopeptide mixture product and application thereof in preparing a medicament for improving the nutritional status and immunologic function of tumor patients receiving radiotherapy and chemotherapy and health food or food. A glycopeptide mixture is prepared by mixing marine oligopeptide and bioactive polysaccharide according to certain proportion. The marine oligopeptide is a group of oligopeptide mixtures with low molecular weights which are produced by taking fish skin, fish meat or fish bone of marine fishes as main raw materials through enzymatic hydrolysis, can be dissolved by trichloroacetic acid, and have relative molecular mass less than 1,000, and has the characteristics of easy absorption, quick absorption, low viscosity, good water solubility, and the like. The bioactive polysaccharide comprises lentinan, ganoderan, grifola polysaccharide, panaxan, lycium bararum polysaccharide and algal polysaccharide. Animal experiments and clinical observation prove that the glycopeptide mixture prepared by mixing the marine oligopeptide and the bioactive polysaccharide has the effect of improving the immunologic function of tumor-bearing mice and the nutritional status of the tumor patients receiving radiotherapy and chemotherapy.

Description

technical field [0001] The present invention relates to a glycopeptide mixture and its new application, specifically, the combined preparation of marine oligopeptides extracted from marine fish and bioactive polysaccharides derived from fungi or plants in the preparation of tumor adjuvant therapy drugs and health food use in . It belongs to the field of medicine and food health care. Background technique [0002] The latest research shows that the incidence of 59 kinds of malignant tumors in my country has increased by about 50% in 20 years! Statistics from the Ministry of Health in 2006 show that malignant tumors have become the number one killer of urban and rural residents in China! Chemotherapy and radiotherapy are currently the most effective methods for treating solid tumors other than surgery. However, while chemotherapy and radiotherapy treat tumors, they also have a certain killing effect on normal body tissue cells, especially on tissue cells that proliferate ra...

Claims

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Application Information

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IPC IPC(8): C07K2/00A61K38/02A61K9/08A61K9/14A61K9/20A61K9/48A61P1/14A61P37/04A23L1/305A23L33/125A23L33/18
Inventor 李勇王军波
Owner 李勇
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