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New applications of cholesterol transporter genes and/or their encoded proteins

A transporter and cholesterol technology, applied in the field of biomedicine, can solve the problems of complex pathogenesis, insufficient research, poor clinical prognosis, etc., and achieve highly relevant effects

Active Publication Date: 2022-07-29
SHANDONG UNIV QILU HOSPITAL
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Problems solved by technology

The pathogenesis of AML is complicated and the clinical prognosis is poor. Although combined chemotherapy can make most patients achieve complete remission (CR), only a few special types of AML patients can survive for a long time, and most patients develop disease within 3 years after CR. Relapse, and refractory or relapsed patients have poor chemotherapy effect, so individualized treatment targeting key molecules in the occurrence and development of AML will become the development trend of AML treatment
At present, the research on the mechanism of AML is still insufficient, and the existing molecular targeted drugs are difficult to meet the needs of clinical treatment. Therefore, mining and searching for new key pathogenic molecules and potential intervention targets in the occurrence and development of AML will provide a basis for diagnosis and treatment stratification and prognosis. Evaluation provides new evidence of critical clinical importance

Method used

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  • New applications of cholesterol transporter genes and/or their encoded proteins
  • New applications of cholesterol transporter genes and/or their encoded proteins
  • New applications of cholesterol transporter genes and/or their encoded proteins

Examples

Experimental program
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Effect test

Embodiment 1

[0017] Example 1 Screening and validation of acute myeloid leukemia diagnostic and prognostic marker molecule GRAMD1C

[0018] 1. Materials and methods

[0019] 1 Bioinformatics data analysis tools

[0020] 1.1 The Cancer Genome Atlas (TCGA)

[0021] The TCGA program is funded by the U.S. government and aims to use genome sequencing technology to map all human cancer genome variants and conduct comparative analysis to study the relationship between RNA and protein expression, DNA copy number changes, and patient prognosis. . So far, more than 30 kinds of human tumor data have been included in the TCGA database, which is of great significance for tumor diagnosis and treatment research including AML.

[0022] 1.2 Gene Expression Omnibus (GEO) database

[0023] GEO is an international public database of high-throughput gene expression and other functional genomics data, supported and maintained by the US National Library of Medicine's National Center for Biotechnology Informa...

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Abstract

The invention discloses a new application of cholesterol transporter gene and / or its encoded protein in the preparation of acute myeloid leukemia therapeutic drugs. The invention screens out the molecular markers related to the diagnosis and prognosis of acute myeloid leukemia (AML), and screens out the cholesterol transporter gene (GRAMD1C) which is closely related to the prognosis of AML patients and is differentially expressed in AML; GRAMD1C is correlated with FAB typing and cytogenetic risk stratification in AML patients. The higher the cytogenetic risk, the higher the expression of GRAMD1C; the high expression of GRAMD1C indicates poor prognosis in AML patients; GRAMD1C may participate in Wnt signaling pathway, regulate Transcription factor activity, etc. are involved in the disease progression of AML. GRAMD1C can be used in diagnostic and prognostic research formulations for AML.

Description

technical field [0001] The invention belongs to the field of biomedicine, and particularly relates to a new application of cholesterol transporter genes and / or proteins encoded by them. Background technique [0002] Acute myeloid leukemia (AML) is a malignant clonal disease originating from hematopoietic stem / progenitor cells. , and cause extramedullary infiltration. The pathogenesis of AML is complex and the clinical prognosis is poor. Although most patients can achieve complete remission (CR) with combined chemotherapy, only a few special types of AML patients can survive for a long time, and most patients develop disease within 3 years after CR. Relapsed, and refractory or relapsed patients have poor chemotherapy effects. Therefore, individualized therapy targeting key molecules in the occurrence and development of AML will become the development trend of AML treatment. At present, the research on the mechanism of AML is still insufficient, and the existing molecular ta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886G01N33/574A61K45/00A61P35/02
CPCC12Q1/6886G01N33/57426G01N33/57484A61K45/00A61P35/02C12Q2600/118C12Q2600/158C12Q2600/136
Inventor 陈春燕付悦董玉婷李淼徐曼
Owner SHANDONG UNIV QILU HOSPITAL
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