Molecular detection of chromosome aberrations
a chromosome aberration and molecular detection technology, applied in the field of biotechnology, can solve the problems of inconvenient use, high labor intensity, and inconvenient use of cytogenetic analysis by conventional chromosome banding techniques, and achieve the effects of improving sensitivity, specificity and efficacy of analysis
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[0019] Each year, worldwide, many cases of hematopoietic malignancies are being diagnosed. In the European Union (˜375 million inhabitants) this concerns ˜98,000 patients per year. The estimated number of patients in the USA (˜250 million inhabitants) is ˜65,500 per year. The majority of hematological malignancies are of lymphoid origin: acute lymphoblastic leukemias (“ALL”), chronic lymphocytic leukemias, most malignant lymphomas, and multiple myelomas. The nonHodgkin's lymphomas (“NHL”) form the largest group, representing approximately half of all hematopoietic malignancies. Furthermore, European epidemiological studies show that the incidence of NHL is gradually increasing (˜5% per year), which indicates that NHL poses a significant public health problem in Europe and most probably throughout the Western world. Although the annual number of patients diagnosed with ALL is smaller than for NHL, ALL has a high prevalence in children, representing the most frequent malignancy in chi...
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