2 results about "CYP3A5" patented technology

The present invention discloses the role of targeting CYP3A5 in the treatment of glioma. The present invention provides a biomarker CYP3A5 related to glioma, which can be used for the diagnosis, prognosis judgment, prevention and / or treatment of glioblastoma, and can help clinicians effectively treat glioma patients, having important clinical application value.

The present invention provides compounds for the regulation of P-glycoprotein and cytochrome P450 (e.g., CYP3A4 and CYP3A5 isoforms) enzymes, which a) significantly improve the bioavailability of substrates of these enzymes, including anticancer drugs, b) overcome multidrug resistance in tumors, and c) reduce serious side effects while improving the delivery of P-glycoprotein substrates to the brain. [Solution] Compounds of formula (I), as well as their prodrugs and pharmaceutically acceptable salts, are provided. Further disclosure relates to pharmaceutical compositions containing the compounds, methods of use, and methods for preparing them. TIFF2026086798000135.tif39128