Implant agent treating for solid tumor
A technology for sustained-release implants and tumors, which can be used in anti-tumor drugs, pharmaceutical formulations, active ingredients of boron compounds, etc., and can solve problems such as systemic toxicity and side effects that limit clinical applications.
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Embodiment 1
[0070] Put the weighed (90mg) slow-release auxiliary material (polylactic acid (PLA) with a molecular weight of 10000-20000) into the container, add a certain amount of organic solvent to dissolve and mix (subject to full dissolution), then add 10 mg of boron Tezomib, shake again and dry in vacuo to remove organic solvent. The dried solid composition is shaped immediately, subpackaged and sterilized by radiation to obtain a slow-release implant containing 10% bortezomib. The release time of the slow-release implant in physiological saline in vitro is 15-20 days, and the release time in mouse subcutaneous is 25-30 days.
Embodiment 2
[0072]Sustained-release implants were made according to the method described in Example 1, but the anti-cancer active ingredients contained were one of the following:
[0073] (A) 1% bortezomib and 99% polylactic acid;
[0074] (B) 5% bortezomib and 95% polylactic acid;
[0075] (C) 10% bortezomib and 90% polylactic acid;
[0076] (D) 15% bortezomib and 85% polylactic acid;
[0077] (E) 20% bortezomib and 80% polylactic acid.
Embodiment 3
[0079] Put the weighed (85 mg) sustained-release excipient (PLGA with a molecular weight of 15000-30000, 50:50) into the container, add a certain amount of organic solvent to dissolve and mix (subject to complete dissolution), then add 15 mg of bortezoid m, re-shake and vacuum-dry to remove organic solvents. The dried solid composition is shaped immediately, subpackaged and sterilized by radiation to obtain a slow-release implant containing 15% bortezomib. The release time of the sustained-release implant in physiological saline in vitro is 14-24 days, and the release time in mouse subcutaneous is 20-28 days.
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