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Novel application of nitrate on aspect of preventing radiation-induced salivary gland damage

A technology for radiation damage, nitrates, applied in the field of medicine and health

Inactive Publication Date: 2016-08-24
王松灵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, so far, there is no report on the application of nitrate in the prevention of radiation damage to the salivary glands of organisms.

Method used

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  • Novel application of nitrate on aspect of preventing radiation-induced salivary gland damage
  • Novel application of nitrate on aspect of preventing radiation-induced salivary gland damage
  • Novel application of nitrate on aspect of preventing radiation-induced salivary gland damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: A randomized controlled study on the influence of nitrate-rich diet on salivary flow rate in patients with nasopharyngeal carcinoma undergoing radiotherapy

[0014] 1. Clinical data

[0015] 1.1 General information

[0016] A total of 20 patients who needed intensity-modulated radiotherapy for nasopharyngeal carcinoma were recruited and randomly divided into a nitrate intervention group of 10 cases and a placebo control group of 10 cases. Each patient signed an informed consent before participating in the experiment.

[0017] 1.2 Inclusion criteria

[0018] All included cases were pathologically diagnosed as nasopharyngeal carcinoma, and the clinical stage was stage II-IV.

[0019] 1.3 Exclusion criteria

[0020] If MRI and PET-CT before radiotherapy show tumor invasion or metastasis involving salivary glands, or patients suffer from other diseases involving salivary glands, such as Sjogren's syndrome, etc., or patients have a history of major salivary gl...

Embodiment 2

[0040] Example 2: Experimental Study on Prevention of Radiation Injury to the Parotid Gland of Minipigs by Oral Nitrate

[0041] 1. Purpose

[0042] To explore the effect of nitrate on the prevention and treatment of parotid gland injury caused by radiotherapy.

[0043] 2. Materials and methods

[0044] In this study, 10 miniature pigs (20-25kg body weight) were randomly divided into nitrate intervention group and control group. From 1 week before receiving electron accelerator irradiation (single radiotherapy of 20Gy on one side of the parotid gland) to 3 weeks after radiotherapy, the minipigs in the nitrate intervention group were given sodium nitrate (concentration: 1mM / kg body weight) in their daily diet, and the control group was only given daily diet . The salivary flow rate and parotid gland blood flow decline rate were detected before the intervention and 10 days, 40 days, 70 days, 100 days and 120 days after the intervention. After the experiment, the animals were...

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Abstract

The invention discloses a novel application of nitrate on an aspect of preventing radiation-induced salivary gland damage, and belongs to the fields of medicine and health. Upon clinical researches and animal experiments, it finally verifies that the nitrate, through oral administration, can be used for effectively preventing the radiation-induced salivary gland damage and for improving the symptom of xerostomia in patients with head and neck tumors due to radiotherapy. The nitrate disclosed by the invention can be used for preparing medicine which is effective on preventing the radiation-induced salivary gland damage; therefore, a novel way is provided for the clinical treatment of radiation-induced xerostomia.

Description

technical field [0001] The invention relates to a new application of nitrate in preventing radiation damage to salivary glands, and belongs to the field of medicine and health. Background technique [0002] Salivary gland radiation injury is a common complication of radiotherapy for head and neck tumors. The clinical manifestation is that during and after radiotherapy, the patient has severe dry mouth symptoms, which affect normal physiological functions such as language, taste, and eating, and greatly reduce the patient's quality of life. How to deal with the salivary gland injury caused by radiotherapy for head and neck tumors is one of the clinical problems that need to be solved urgently. In recent years, with the advancement of radiotherapy technology, the degree of salivary gland radiation damage has been alleviated, and clinicians are also seeking some other means to protect the function of salivary glands, such as the application of artificial saliva, the developmen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61K33/06A61P1/00
Inventor 王松灵曲兴民吴志芳秦力铮夏登胜郑颖张春梅
Owner 王松灵
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