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Medicinal composition for treating xerostomia after radiotherapy of head and neck tumors and application thereof

A head and neck tumor and composition technology, applied in the field of traditional Chinese medicine, can solve problems affecting the quality of life of patients, difficulty in swallowing, coughing when eating, etc., and achieve the effects of increasing appetite, improving immune function, and reducing recurrence

Inactive Publication Date: 2014-05-07
QINGDAO HISER MEDICAL CENT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the salivary glands are often located in the radiation field, they will inevitably be damaged during the radiation process, causing side effects such as dry mouth, which can lead to dysgeusia, dental caries, dysphagia, coughing when eating, etc., seriously affecting the quality of life of patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Herbal medicine prescription: Sophora japonica 3.6 kg, honeysuckle 1.7 kg, Yu Liren 3.0 kg, lotus leaf 1.0 kg, fat sea 1.7 kg, bamboo leaf 3.6 kg, tangerine peel 1.5 kg.

[0016] Preparation method: Weigh the raw materials of the above-mentioned Chinese medicinal materials in the prescribed amount, wash and remove impurities, dry them, and crush them; then add water to the above-mentioned granular medicinal materials to cover the surface of the medicine for 2cm, soak for 1-1.2h, remove the medicinal materials and put them in a multi-functional extraction tank Add water to the medium and decoct twice, add 10 times the amount of medicinal materials for the first time, decoct for 2 hours, take the decoction, filter, add 8 times the amount of water for the second time, decoct for 1 hour, take two decoctions The solutions were combined, filtered, and concentrated to a concentrated solution with a relative density of 1.15g / mL at 90°C; the concentrated solution was refrigerated...

Embodiment 2

[0018] Herbal medicine prescription: Sophora japonica 4.1 kg, honeysuckle 1.8 kg, Yu Liren 2.5 kg, lotus leaf 1.0 kg, fat sea 1.3 kg, bamboo leaf 3.0 kg, tangerine peel 1.2 kg.

[0019] Preparation method: Weigh the raw materials of the above-mentioned Chinese medicinal materials in the prescribed amount, wash and remove impurities, dry them, and crush them; then add water to the above-mentioned granular medicinal materials to cover 2 cmm of the medicinal surface, soak for 1-1.2 hours, remove the medicinal materials and put them in a multi-functional extraction tank Add water to the middle and decoct twice. For the first time, add 8 times the amount of medicinal materials, decoct for 2 hours, take the decoction, filter, add 8 times the amount of water for the second time, decoct for 1 hour, and decoct twice. The solutions were combined, filtered, and concentrated to a concentrated solution with a relative density of 1.15g / mL at 90°C; the concentrated solution was refrigerated a...

Embodiment 3

[0021] Herbal medicine prescription: Sophora japonica 2.8 kg, honeysuckle 1.3 kg, Yu Liren 3.7 kg, lotus leaf 1.4 kg, fat sea 3.0 kg, bamboo leaf 4.5 kg, tangerine peel 2.0 kg.

[0022] Preparation method: Weigh the raw materials of the above-mentioned Chinese medicinal materials in the prescribed amount, wash and remove impurities, dry them, and crush them; then add water to the above-mentioned granular medicinal materials to cover the surface of the medicine for 2cm, soak for 1-1.2h, remove the medicinal materials and put them in a multi-functional extraction tank Add water to the middle and decoct twice. For the first time, add 8 times the amount of medicinal materials, decoct for 2 hours, take the decoction, filter, add 6 times the amount of water for the second time, decoct for 1 hour, and decoct twice. The solutions were combined, filtered, and concentrated to a concentrated solution with a relative density of 1.15g / mL at 90°C; the concentrated solution was refrigerated a...

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Abstract

The invention relates to a medicinal composition for treating xerostomia after radiotherapy of head and neck tumors and an application thereof. The medicinal composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 28-45 parts of sophora japonica flower, 13-21 parts of flos Lonicerae, 24-37 parts of semen pruni, 8-14 parts of lotus leaf, 13-21 parts of sterculia lychnophora, 28-45 parts of bamboo leaf and 12-20 parts of citrus reticulata. The medicinal composition disclosed by the invention can not only keep oral cavity wet and clean and increase appetite, but also can reduce discomfortableness caused by radiotherapy of head and neck tumors.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for treating xerostomia after radiotherapy for head and neck tumors and an application thereof. Background technique [0002] There are different changes in the quality and quantity of saliva in the oral cavity during the course of radiotherapy for head and neck tumors and in patients who receive repeated intermittent radiotherapy, and the amount of saliva secretion gradually decreases with the increase of radiation dose or frequency. This is due to radiation therapy damage to the main salivary glands leading to post-radiation xerostomia. [0003] Head and neck tumors account for 30% of the total body cancer, and radiotherapy is the main treatment for head and neck tumors. Since the salivary glands are often located in the radiation field, they are inevitably damaged during the radiation process, causing side effects ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P1/02A61P1/14A61P37/04A61P35/00A61P35/04
Inventor 念丁芳燕爱凤侯立泳孙典学
Owner QINGDAO HISER MEDICAL CENT
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