140 results about "Autoimmune xerostomia" patented technology

This invention encompasses an oral composition for treating or preventing dry mouth with following benefits: antibacterial/anti-fungal efficacy, low irritancy, and moisture retention. The compositions can be a toothpaste, a mouth rinse or a spray and include one or more non-ionic surfactants, as foaming agents, one or more broad spectrum anti-microbial ingredient, such as chlorhexidine and cetylpyridinium chloride, and one or more oral surface adhesive polysaccharides that can encage cationic actives to help the deposition and retention of the agents onto oral surfaces and thus provide antimicrobial efficacy.

The present invention provides compositions and methods for increasing therapeutic gain in radiotherapy and chemotherapy for proliferating malignant or nonmalignant disease to produce high probability of tumor control with low frequency of sequelae of therapy by administering a therapeutically effective amount of a histone deacetylase inhibitor. The compounds are capable of simultaneously stimulating the epithelium regrowth, inhibiting the fibroblast proliferation, decreasing the collagen deposit, suppressing the fibrogenic growth factor, subsiding the proinflammatory cytokine and modulating the expression of cell cycle genes, tumor suppressors and oncogenes, and are useful to increase the therapeutic gain in radiotherapy and chemotherapy, which results in decrease of skin swelling and inflammation, promotion of epithelium healing in mucosa and dermis, decrease of xerostomia, prevention/reduction of severity of plantar-palmar syndrome, prevention of tissue fibrosis, ulceration, necrosis and tumorigenesis, and increase of tumor growth inhibition and tumor therapy effectiveness.

A method comprises creating a predetermined pattern of treatment microzones in oral tissue affected by a condition, applying energy of predetermined characteristics to the soft tissue through a tip being limited by at least one dimensional feature of the oral tissue. The application of energy to the oral tissue after creating the predetermined pattern of treatment microzones in the oral soft tissue is terminated. A type of the energy and the characteristics of the predetermined pattern of treatment microzones are defined by the condition in the soft tissue. The condition in the oral tissue can be a gingival recession, gingivitis, periodontal disease, xerostomia, black triangle disease, and interdental/interimplant papilla deficiencies. The oral tissue can be oral soft tissue, such as oral mucosa soft tissue or a gingival soft tissue.

The invention relates to a Chinese medicinal preparation for treating nervous headache, which comprises the following raw material medicines: Chinese angelica, bupleurum, root of red-rooted salvia, peach seed, manchurian wildginger, white paeony root, largehead atractylodes rhizome, incised notopterygium rhizome, szechuan lovage rhizome, myrrh, polygalae root, platycladi seed, silktree albizzia bark, tall gastrodia tuber, gambir plant and eucommia bark, wherein for patients who suffer from yin deficiency and yang excess and wind-evil invasion, weeping forsythia, cassia seed, baical skullcap root and dwarf lilyturf tuber are added into the raw material medicines; for patients who suffer from dizziness, vexation, xerostomia and bitterness in mouth and upward invasion of liver-fire, angelica dahurica, common selfheal fruit-spike, prepared tuber of multiflower knotweed and gardenia jasminoides are added into the raw material medicines; and for patients who suffer from insomnia, dreaminess, deficiency of qi and blood stasis, raw rehmannia root, astragalus, spina date seed, curcuma aromatica and tuber feeceflower stem are added into the raw material medicines. In the Chinese medicinal preparation, the selected raw material medicines are mainly used for dispelling wind and eliminating cold, eliminating blood stasis and removing obstruction in channels, invigorating blood circulation, promoting qi and relieving pain, and can address both symptoms and root causes based on the theory with syndrome differentiation. 'Pain onsets when obstructed and goes when passable', so a method for removing obstruction in channels to relieve pain is mainly adopted on treatment. By the Chinese medicinal preparation, the angiokinesis function restores to be normal, branch artery spasm is removed, the blood supply of local tissue restores to be normal, and microcirculation is improved, so that channels and collaterals are dredged to fulfill the aim of 'pain goes when passable'.

New liquid compositions are described for the relief of the xerostomia and the treatment of associated disorders, in which the compositions contain: a) saline saliva substitute agents selected from the group consisting of sodium chloride, potassium chloride, sodium bicarbonate, monobasic potassium phosphate, and dibasic phosphate potassium; b) saliva production stimulation agents selected from the group consisting of citric acid or its alkali metal salts and malic acid or its alkali metal salts; c) oral antiseptics selected from the group consisting of triclosan, chlorhexidine and its salts, benzalkonium and its salts, and cetylpyridinium chloride; d) anticariogenic agents selected from the group consisting of fluoride sodium, sodium monofluorophosphate, and xylitol; and e) oral mucosa protective agents selected from the group consisting of vitamin E acetate, panthenol, dipotassium glycyrrhizinate and extracts of aloe vera. The aforementioned compositions are presented in the form of mouthwashes, sprays, oral gels, and toothpastes.

Compositions having high fluoride ion recovery comprising a hydrocolloid, a heteropolysaccharide, a PVME/MA copolymer, and a fluoride ion source and use thereof, e.g., in the treatment of xerostomia and/or sensitive teeth.

The invention provides an application of hyaluronic acid and hyaluronate in preparation of a composition for treating and alleviating xerostomia and the composition for treating and alleviating xerostomia. As hyaluronic acid and hyaluronate thereof are in double helix columnar structures, and massive hydroxyls exist inside the double helix structures, the hyaluronic acid and hyaluronate thereof have a very good water holding effect, so that the hyaluronic acid and hyaluronate thereof have lasting moisturizing effect on oral cavity. Furthermore, the hyaluronic acid and hyaluronate thereof can promote wound healing and have the effects of healing anabrosis and the like. In addition, the hyaluronic acid and hyaluronate thereof are colorless and tasteless and free from toxicity, belong to synthetic substances in human body, and are easy to be compatible with ions such as sodium, potassium, calcium, zinc, ferrum and silver ions, so that the hyaluronic acid and hyaluronate thereof have the taste which is suitable for being accepted by human body.

The invention provides a composition for relieving xerostomia and a preparation method thereof. Effective constituents in the composition are one or more of a hyaluronic acid, Pulullan and a polyglutamic acid. The composition has the feature of relieving chronic and transient xerostomia caused by diseases, medicine using, radio therapy, chemotherapy and aging. The composition prepared from raw materials with high biosecurity can lubricate oral cavities and keep the oral cavities moist, and can be prepared into toothpaste, mouthrinse, chewing gum and the like. The prepared composition for relieving xerostomia does not have toxic or side effects on human bodies, and allergy or irritation is avoided.

A sialogogue characterized by comprising polyglutamic acid or its salt. This sialogogue is blended into an oral composition and a food product. This sialogogue is capable of rendering the oral mucosa pleasant even in the case of severe xerostomia.

The present invention provides a liquid preparation composition comprising a solvent and a surfactant dissolving in the solvent, the surface tension of the liquid preparation composition is less than 60mN / m, and the pH of the liquid preparation composition is 5.0-7.4. The present invention also discloses a preparation method of the liquid preparation composition and use of the liquid preparation composition in treatment of otitis media, otitis externa, rhinitis, nasosinusitis, lower respiratory tract inflammation, xerostomia, xerophthalmia and dry noses. The present invention also discloses a preparation comprising the liquid preparation composition. The liquid preparation composition can effectively relieve the otitis media, the otitis externa, the rhinitis, the nasosinusitis, the lower respiratory tract inflammation, the xerostomia, the xerophthalmia, the dry noses and other symptoms, can be used in the form of sprays or liquid droplets, can be applied to an effective site without use of a propellant or an atomization device, is easy to operate, and can effectively avoid stimulation and injury caused by the propellant and use inconvenience of the atomization device.

Compositions for the treatment of xerostomia, and methods of making and using thereof are disclosed herein. The compositions are typically in the form of a film or tablet, such as a double layer sticker tablet. The compositions adhere to a buccal surface or mucosal surface in the oral cavity for at least 15 minutes, preferably for at least 30 minutes. The compositions themselves are able to increase the levels of saliva in the mouth without the need for active agents, such sialogogic agents. The compositions optionally contain a non-lipid lubricant, a flavoring agent, and/or a buffering agent. The composition is generally effective at treating or ameliorating the effects of xerostomia for a time period ranging from at least 30 minutes up to eight hours following administration to the buccal or oral mucosa.

The invention discloses oral care composition for treating xerostomia and an application of the oral care composition in toothpaste. The oral care composition for treating xerostomia contains Chinese herbal medicine extract and bio-enzyme, wherein the Chinese herbal medicine extract is one or more of dendrobium extract, radix polygonati officinalis extract and radix ophiopogonis extract; the bio-enzyme is one or more of lysozyme, lactoperoxidase, amylase, amyloglucosidase and glucose oxidase. The oral care composition has the effect of relieving xerostomia, on one hand, the oral care composition can stimulate salivary secretion, and on the other hand, the oral care composition contains a component similar to protein or enzyme in saliva, thereby being capable of playing the role of artificial saliva, having the sterilization effect and being capable of relieving discomfort caused by xerostomia after use.

The present invention provides a preparation, which comprises a container and a liquid preparation composition accommodated in the container, wherein the liquid preparation composition is an emulsion and comprises a solvent and surfactant-containing liquid droplets distributed in the solvent, the average volume particle size of the liquid droplet is less than or equal to 100 [mu]m, the surface tension of the liquid preparation composition is less than 60 mN/m, the absolute value of the zeta potential is more than or equal to 15 mV, and the container is a sprayer or liquid dropping device. The present invention further discloses a preparation method of the preparation, and uses of the preparation in treatment of otitis media, otitis externa, rhinitis, sinusitis, lower respiratory tract inflammation, xerostomia, xeroma, and dryness in the nasal cavity. According to the present invention, the preparation can relieve otitis media, otitis externa, rhinitis, sinusitis, lower respiratory tract inflammation, xerostomia, xeroma, dryness in the nasal cavity, and other symptoms, can be used in the spray agent or liquid dropping agent form, can be applied without the use of the propellant or atomization device, such that the operation is easy, and the irritation and injury caused by the propellant and the use inconvenience of the atomization device can be avoided.

A medicament used for prophylactic and/or therapeutic treatment of xerostomia, which is in the form for oral mucosal administration comprising a spirooxathiolane quinuclidine derivative represented by the following general formula (I) or an acid addition salt thereof:

[Formula 1]

(wherein R¹ and R² may be the same or different, and independently represent a hydrogen atom, an alkyl group, a cyclopentyl group, a cyclohexyl group, a monoaryl- or diaryl-substituted methylol group, or an aryl-substituted alkyl group) as an active ingredient.

Novel pharmaceutical composition for accelerating salivation and for prophylaxis and/or treatment of xerostornia, which comprises as an active ingredient a carbostyril compound of the formula (1), wherein R is a halogen atom, and the substitution position of the subsistuent on said carbostyril nucleus is the 3- or 4-position, and the bond between the 3- or 4-positions of the carbostyril nucleus is either a single bond or a double bond, or a pharmaceutically acceptable salt thereof. The pharmaceutical composition of the present invention exhibits an accelcrating activity of salivation, and is useful in the prophylaxis or treatment of Xerostomia or hyposalivation.

The invention relates to artificial saliva, which comprises a plurality of inorganic salt, HPMC, a preservative, a flavoring agent and other components. The artificial saliva has the following advantages that: (1) the artificial saliva can rapidly improve symptoms of a patient suffering from xerostomia, and can maintain the function in a longer period; (2) the artificial saliva has good stability; and (3) the artificial saliva has a good mouthfeel when in use.

The present invention provides a preparation composition comprising a solvent, a drug component and a surfactant, the preparation composition is emulsion, surfactant-containing liquid droplets are distributed in the solvent, the volume average particle diameter of the liquid droplet is 100mum or less, the drug component comprises one drug or more drugs for treatment of otitis media, otitis externa, rhinitis, nasosinusitis, lower respiratory tract inflammation, xerostomia, xerophthalmia and dry noses, the surface tension of the preparation composition is less than 60mN / m, and the absolute value of the zeta potential is more than 15mV. The present invention also discloses a preparation method and use of the preparation composition. The preparation composition can relieve the otitis media, the otitis externa, the rhinitis, the nasosinusitis, the lower respiratory tract inflammation, the xerostomia, the xerophthalmia, the dry noses and other symptoms, can be used in the form of sprays or liquid droplets, can be applied to an effective site without use of a propellant or an atomization device, is easy to operate, and can effectively avoid stimulation and injury caused by the propellant and use inconvenience of the atomization device.

The invention relates to a medicine for treating respiratory diseases and a preparation method thereof, wherein each 1000 ml of finished product comprises 55-70 g of folium eriobotryae, 15-25 g of bulbus fritillariae cirrhosae, 12-22 g of platycodon grandiflorum, 1-4 g of snake gall juice and 15-25 g of pinellia. According to the medicine for treating respiratory diseases and the preparation method thereof in the invention, the selected snake gall has the functions of clearing liver and improving vision, dispelling wind-evil, reducing phlegm, clearing heat and detoxicating, so that the medicine has good treatment as well as prevention and healthcare functions on such symptoms as excessive ingestion of alcohol and tobacco, irascibility, xerostomia, dry throat, sore throat and dumb sound. People are easy to catch cold in warm spring and are subjected to cough mostly, so that the medicine is taken for relieving cough and eliminating phlegm; people are fretful and thirsty in hot summer, so the kidney and yin are easy to be negatively affected, and the medicine is taken for nourishing yin and promoting the production of body fluid; people are excited in dry autumn, so the liver fire is strong, and the medicine is taken for eliminating dry stagnation in viscera; and people are cold and fretful in cold winter, so the lung channels are easy to be negatively affected, and the medicine is taken for moistening lung and relieving cough.

The present invention relates to an oral composition and method for alleviating the symptoms associated with xerostomia using encapsulated cation-releasing compounds formulated either intimately together or in separate compartments in a composition containing cation-sensitive mucoadhesive polymers.

The present invention relates to compositions and comestibles that impart a mouth-moistening effect when orally consumed by an individual. More specifically, the compositions of the present invention may include a blend of components, such as a sweetening composition, food-grade acid composition and a cooling agent, that reduces or eliminates the perception of mouth dryness in an individual. The present invention also provides methods for preparing such comestibles, as well as methods of treating xerostomia by orally administering such comestibles.

The invention discloses a spray for treating radioactive xerostomia and a preparation method thereof. The spray is prepared by adding a plurality of plant extracts based on the conventional artificial saliva and has a cool sweet taste and a plurality of effects, such as diminish inflammation, antibiosis, tooth cleaning, whistle wetting and the like. Compared with the conventional artificial saliva, the spray of the invention has the advantages that: because menthol, momordica glycosides V and stevioside A are added in the formula of the spray, the product has the cool sweet taste and patients enjoy in mouthfeel, and by fully meeting the requirements of the patients with diabetes, obesity and the like, disadvantageous consequences probably caused by a sweetener contained in the product are avoided; because a Chinese globeflower extract, a liquorice root water extract, a wild chrysanthemum water extract and a perilla water extract are added in the spray, the product has the cool sweet taste and also the plurality of effects, such as diminish inflammation, antibiosis, tooth cleaning, whistle wetting and the like, and contributes to the maintenance of oral hygiene and the prevention of oral infection; and because the using times is a few, the spray contributes to the effective remission of thirst.