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Composition for relieving xerostomia and preparation method thereof

A composition and symptom technology, applied in the direction of drug combination, medical preparations containing active ingredients, chewing gum, etc., can solve problems such as affecting appetite, affecting digestive system function, and limited ability to dry mouth

Inactive Publication Date: 2016-01-27
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patients have more difficulty eating drier foods due to inability to produce enough saliva
At the same time, due to the reduction of saliva secretion, the ability of saliva to dilute or wash away harmful bacteria is reduced, which reduces the self-cleaning ability of the patient's oral cavity, and the symptoms of dental caries, bad breath, periodontitis, dry throat, and abnormal taste also occur to varying degrees. , and even affect appetite, thereby affecting the function of the digestive system
At present, artificial saliva is a relatively common treatment method, but the commonly used artificial saliva is sodium carboxymethylcellulose and mucin, which has limited ability to solve dry mouth.

Method used

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  • Composition for relieving xerostomia and preparation method thereof
  • Composition for relieving xerostomia and preparation method thereof
  • Composition for relieving xerostomia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Add 0.075% hyaluronic acid, 0.05% pullulan, and 0.05% polyglutamic acid in toothpaste to 57.375% deionized water, stir and dissolve, and mix with 16% sorbitol, 14% hydrated silica, and 9% glycerin , 2.2% sodium lauryl sulfate, 1.0% essence, 1.0% cellulose gum, 0.23% sodium pyrophosphate, 0.22% sodium saccharin, and 0.02% sodium benzoate are mixed, sent to a three-in-one vacuum paste machine, high-speed stirring and grinding for 30 Minutes, vacuum degassing; add essence and then stir and grind for 15 minutes to mix well to obtain toothpaste paste, which is packaged after aseptic filling.

Embodiment 2

[0015] Add 0.075% of hyaluronic acid, 0.05% of pullulan, and 0.05% of polyglutamic acid in the mouthwash water into 99.025% deionized water and stir to dissolve, and mix with 0.3% sodium chloride, 0.1% calcium chloride, 0.3% Potassium chloride, 0.15% disodium hydrogen phosphate, and 0.02% sodium benzoate are mixed, stirred at high speed until all substances are dissolved, and packaged after aseptic filling.

Embodiment 3

[0017] According to the ratio of 0.075% hyaluronic acid, 0.05% pullulan, 0.05% polyglutamic acid, 18.0% pullulan, 0.04% xanthan gum, 0.06% locust bean gum and 0.19% carrageenan in refreshing tablets 76.685% deionized water at 70-80°C; then add 0.4% glycerin, 1.5% acesulfame potassium and essence, 3% menthol, and stir for 2-3 hours to obtain a glue; vacuum removes air bubbles; The film-forming liquid is coated on the stainless steel plate with a knife-type film applicator, and the thickness of the film is controlled at 20-30 μm; steam-dried at a drying temperature of 80-90 °C; and the film is removed.

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PUM

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Abstract

The invention provides a composition for relieving xerostomia and a preparation method thereof. Effective constituents in the composition are one or more of a hyaluronic acid, Pulullan and a polyglutamic acid. The composition has the feature of relieving chronic and transient xerostomia caused by diseases, medicine using, radio therapy, chemotherapy and aging. The composition prepared from raw materials with high biosecurity can lubricate oral cavities and keep the oral cavities moist, and can be prepared into toothpaste, mouthrinse, chewing gum and the like. The prepared composition for relieving xerostomia does not have toxic or side effects on human bodies, and allergy or irritation is avoided.

Description

technical field [0001] The invention relates to a composition for alleviating dry mouth symptoms and a preparation method thereof. The active ingredient in the composition is one or more of hyaluronic acid, pullulan and polyglutamic acid. The composition is toothpaste, Mouthwash, refreshing tablets and chewing gum belong to the field of medical and health care products. Background technique [0002] Xerostomia is a common symptom in dental clinics. Xerostomia is the patient's lack of saliva secretion, dry mouth, foreign body sensation, and burning sensation, which will make it difficult for the patient to speak. Due to insufficient salivation, patients have more difficulty eating drier foods. At the same time, due to the reduction of saliva secretion, the ability of saliva to dilute or wash away harmful bacteria is reduced, which reduces the self-cleaning ability of the patient's oral cavity, and the symptoms of dental caries, bad breath, periodontitis, dry throat, and abn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/785A61K9/20A61K8/73A61K8/88A61P1/02A61Q11/00A23L33/10A23G4/06A61K31/728A61K31/715
Inventor 孟祥璟刘少英宗工理赵文刚边玲朱希强凌沛学
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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