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Preparation, preparation method and uses thereof

A preparation and liquid preparation technology, applied in anti-inflammatory agents, therapeutic nebulizers, non-central analgesics, etc., can solve problems such as rapid relief, and achieve the effects of promoting recovery, reducing the chance of infection, and eliminating tinnitus

Inactive Publication Date: 2016-03-02
SHENZHEN HIGHTIDE BIOPHARM +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in these treatment methods, except for surgery, none of them can quickly relieve the patient's discomfort symptoms such as earplugs, nasal congestion, pain, cough, wheezing, dry eyes, dry mouth and dry nose in a short period of time (minutes-hours).

Method used

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  • Preparation, preparation method and uses thereof

Examples

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Effect test

preparation example Construction

[0086] Simultaneously, the present invention also provides the preparation method of above-mentioned preparation, comprise:

[0087] S1. Disperse the liquid surfactant in 40-60KHZ ultrasound for 1-3min;

[0088] S2. Under stirring conditions with a rotation speed of 3000 rpm or more, uniformly mix the liquid surfactant and the solvent to form a liquid formulation composition in which droplets containing the surfactant are dispersed in the solvent, and the surface tension of the liquid formulation composition is Less than 60mN / m, the absolute value of zeta potential is above 15mV;

[0089] S3. Put the above-mentioned liquid preparation composition into a container; the container is a sprayer or a dropper or an anti-pollution sprayer or dropper. .

[0090] In the above-mentioned preparation method, for the surfactant, the specific materials that can be used are as mentioned above, which can be lecithin, sterol, pulmonary surfactant, poloxamer, dipalmitoylphosphatidylcholine, c...

Embodiment 1

[0121] This example is used to illustrate the formulation disclosed in the present invention and its preparation method.

[0122] Weigh 2.38 g of hydrogenated phospholipids, 0.12 g of sterols, 0.4 g of methylparaben, 0.2 g of ethylparaben and 0.1 g of menthol and place them in a container. Add 1ml of absolute ethanol, dissolve with ultrasound (40KHZ), mix well under high-speed stirring (6000rpm), continue to add water to a final volume of 100ml, mix well, pour into a sprayer or dropper, and seal. After testing the quality parameters such as appearance properties, loading capacity, main component content, per spray volume (or per drop volume), microbial limit, etc., it is packaged after meeting the requirements, and it is ready.

[0123] The surface tension of the final product was detected by an automatic surface tension tester (USKino, A601) to be 48.851mN / m. The particle size distribution of the product was measured with a laser particle size analyzer Mastersizer 2000 (Malv...

Embodiment 2

[0126] This example is used to illustrate the formulation disclosed in the present invention and its preparation method.

[0127] Weigh 2.35g of soybean lecithin, 0.15g of poloxamer, 0.08g of vitamin E and 0.5g of phenylethyl alcohol and place them in a container. Add 1ml of absolute ethanol, dissolve with ultrasound (40KHZ), stir evenly at high speed (6000rpm), continue to add water to a final volume of 100ml, mix evenly, pour into a sprayer or dropper, and seal. After testing the quality parameters such as appearance properties, loading capacity, main component content, per spray volume (or per drop volume), microbial limit, etc., it is packaged after meeting the requirements, and it is ready.

[0128] The surface tension of the final product was detected by an automatic surface tension tester (USKino, A601) to be 16.252mN / m. The particle size distribution of the product was measured by a laser particle size analyzer Mastersizer 2000 (Malvern Instruments Ltd, UK), and the r...

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Abstract

The present invention provides a preparation, which comprises a container and a liquid preparation composition accommodated in the container, wherein the liquid preparation composition is an emulsion and comprises a solvent and surfactant-containing liquid droplets distributed in the solvent, the average volume particle size of the liquid droplet is less than or equal to 100 [mu]m, the surface tension of the liquid preparation composition is less than 60 mN / m, the absolute value of the zeta potential is more than or equal to 15 mV, and the container is a sprayer or liquid dropping device. The present invention further discloses a preparation method of the preparation, and uses of the preparation in treatment of otitis media, otitis externa, rhinitis, sinusitis, lower respiratory tract inflammation, xerostomia, xeroma, and dryness in the nasal cavity. According to the present invention, the preparation can relieve otitis media, otitis externa, rhinitis, sinusitis, lower respiratory tract inflammation, xerostomia, xeroma, dryness in the nasal cavity, and other symptoms, can be used in the spray agent or liquid dropping agent form, can be applied without the use of the propellant or atomization device, such that the operation is easy, and the irritation and injury caused by the propellant and the use inconvenience of the atomization device can be avoided.

Description

technical field [0001] The invention relates to a preparation, a preparation method thereof, and an application of the preparation. Background technique [0002] Otitis media, otitis externa, rhinitis and sinusitis are common ENT diseases. Among them, otitis media is an inflammatory lesion involving all or part of the structure of the middle ear (including the Eustachian tube, tympanic cavity, tympanic antrum, and mastoid air cells), and it is more common in children. Can be divided into non-suppurative and suppurative two categories. Non-suppurative cases include secretory otitis media and barotrauma otitis media (caused by changes in aircraft take-off and landing pressure, increased diving water pressure, etc.); suppurative cases can be divided into acute and chronic cases. Otitis externa (Otitis externa) is the inflammation of the external auditory canal infection, often caused by ear picking, ear scratching or sewage entering the external auditory canal. Otitis extern...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61M11/00A61M35/00A61P27/16A61P11/02A61P29/00A61P11/14A61P11/06A61P27/02A61P1/02
Inventor 于莉詹姆斯·格瑞·弗格森
Owner SHENZHEN HIGHTIDE BIOPHARM
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