The invention provides a negative-pressure disinfection mixing treatment device for a shelter hospital, which is characterized in that a T-shaped channel with a sliding cavity is arranged in a stirring rotating shaft, an extrusion pipe is communicated with the T-shaped channel with the sliding cavity, the extrusion pipe is connected to the stirring rotating shaft, an extrusion one-way valve is arranged in the extrusion pipe, blades are arranged on eccentric wheels, the eccentric wheels are vertically and symmetrically connected to an output shaft of a double-shaft motor, the double-shaft motor is arranged in a base with a sliding rod, the output shaft of the double-shaft motor is rotationally connected with the base with the sliding rod, the base with the sliding rod is connected with a piston, the base with the sliding rod and the piston are both in sliding connection with the T-shaped channel with the sliding cavity, the base with the sliding rod is sleeved with a first spring, a pipe with a push-down blade is communicated with the T-shaped channel with the sliding cavity, the pipe with the push-down blade is connected with the stirring rotating shaft, a suction one-way valve is arranged in the pipe with the push-down blade, a liquid outlet channel is arranged on a mixing machine shell and enables the mixing machine shell to be communicated with a liquid outlet box, and the disinfection mixed liquid with the good mixing degree is manufactured on the premise that the flowing efficiency is not affected.