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Glaucoma drainage tube and preparation method thereof

A drainage tube and glaucoma technology, applied in the field of glaucoma drainage tube and its preparation, can solve the problems of glaucoma drainage tube research and development difficulties, inapplicability to pigmentary glaucoma, failure of glaucoma surgery, etc., to achieve no risk of loss, good treatment of glaucoma, no immunity original effect

Active Publication Date: 2020-07-31
广东赛珐生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the sticky canaloplasty used in domestic hospitals is a kind of operation to open up the physiological drainage channel from the anterior chamber to Schlemm's canal, but this kind of Schlemm's canal drainage is not suitable for pigmented trabecular mesh blockage Pigmentary glaucoma and open-angle glaucoma with subscleral venous pressure
(2) The key to the success of subconjunctival drainage surgery is the formation of functional filtering blebs. This type of surgery will have some complications at the same time, such as scarring of filtering blebs, thinning of filtering blebs, etc., which will result in failure of glaucoma surgery
Because of this, the research and development of glaucoma drainage tube has great difficulties

Method used

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  • Glaucoma drainage tube and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] This embodiment provides a glaucoma drainage tube, the ratio of raw materials is:

[0043] Component A (soft segment monomer): 20wt% of 2-phenylethyl acrylate;

[0044] Component B (hard segment monomer): 20wt% of 2-phenylethyl methacrylate;

[0045] C component (soft segment monomer): ethyl acrylate 55wt%;

[0046] Initiator: bis(4-tert-butylcyclohexyl) peroxydicarbonate 2.6wt%;

[0047] Crosslinking agent: 1,4-butanediol diacrylate 2.4wt%;

[0048] Lifting wire: 316L stainless steel wire with an outer diameter of 45 μm;

[0049] The preparation process is as follows:

[0050] (1) Fully mix the A component, B component, C component and the initiator, react at 40°C for about 2 to 10 hours, wait for the viscosity of the reaction liquid to be 0.5pa.s, quickly cool down to 0°C to stop the reaction , to obtain a prepolymerized sol-gel;

[0051] (2) Add the cross-linking agent to the sol-gel liquid obtained in step (1), mix, and pull it with a 316L stainless steel wire...

Embodiment 2

[0054] This embodiment provides a glaucoma drainage tube, the ratio of raw materials is:

[0055] Component A (soft segment monomer): 25wt% of 2-phenoxyethyl acrylate;

[0056] Component B (hard segment monomer): 20wt% of 2-phenoxyethyl methacrylate;

[0057] Component C (soft segment monomer): 50wt% butyl acrylate;

[0058] Initiator: benzoyl peroxide 2.6wt%;

[0059] Crosslinking agent: 1,4-butanediol dimethacrylate 2.4wt%;

[0060] Lifting wire: 316L stainless steel wire with an outer diameter of 45 μm;

[0061] The preparation process is as follows:

[0062] (1) Fully mix the A component, B component, C component and the initiator, react at 40°C for about 2-10 hours, wait for the viscosity of the mixed liquid to be 1pa.s, quickly cool down to 0°C to stop the reaction, Obtain cross-linked prepolymerized sol-gel;

[0063] (2) Add the cross-linking agent to the sol-gel solution obtained in step (1), mix, and pull with a 316L stainless steel wire with an outer diameter o...

Embodiment 3

[0066] This embodiment provides a glaucoma drainage tube, the ratio of raw materials is:

[0067] Component A (soft segment monomer): 30wt% of 2-phenylethyl acrylate;

[0068] Component B (hard segment monomer): 35wt% of 2-phenylethyl methacrylate;

[0069] C component (soft segment monomer): ethyl acrylate 30wt%;

[0070] Initiator: bis(4-tert-butylcyclohexyl) peroxydicarbonate 2.6wt%;

[0071] Crosslinking agent: 1,4-butanediol diacrylate 2.4wt%;

[0072] Lifting wire: 316L stainless steel wire with an outer diameter of 45 μm;

[0073] The preparation process is as follows:

[0074] (1) Fully mix the A component, B component, C component and the initiator, react at 40°C for about 2 to 10 hours, wait for the viscosity of the mixed liquid to be 2pa.s, quickly cool down to 0°C to stop the reaction, Obtain cross-linked prepolymerized sol-gel;

[0075] (2) Add the cross-linking agent to the sol-gel liquid obtained in step (1), mix, and pull it with a 316L stainless steel wi...

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Abstract

The invention relates to a glaucoma drainage tube and a preparation method thereof. The glaucoma drainage tube is prepared from the following raw materials in percentage by mass: 0-30wt% of a component A, 5-35wt% of a component B, 30-60t of a component C, 0.2-5wt% of an initiator and 2-10wt% of a crosslinking agent; the component A is aryl alkyl acrylate or aryloxy alkyl acrylate; the component Bis aryl alkyl methacrylate or aryloxy alkyl methacrylate; and the component C is ethyl acrylate or butyl acrylate. The glaucoma drainage tube is suitable for minimally invasive implantation, and has good tissue compliance, good biocompatibility and high safety.

Description

technical field [0001] The invention relates to the field of biological materials, in particular to a glaucoma drainage tube and a preparation method thereof. Background technique [0002] Glaucoma is the second most common cause of blindness in the world. It is a kind of optic nerve damage disease caused by pathological high intraocular pressure. Controlling intraocular pressure has become the main method for the treatment of glaucoma. Clinically, most glaucoma diseases can be treated by drainage device implantation, which can achieve the effect of lowering intraocular pressure and achieve controlled treatment of glaucoma. [0003] There are three main ways of drainage of aqueous humor with glaucoma drainage device: subconjunctival drainage, Schlemm's canal (Schlemm) drainage and chorioscleral drainage. (1) The main physiological pathway for the outflow of aqueous humor is Schlemm's canal. The therapeutic principle of the Schlemm's canal drainage device is to open the phys...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/14C08F220/18C08F220/30C08F222/14A61F9/00
CPCA61L31/048A61L31/14C08F220/18C08F220/30A61F9/00781C08L35/02
Inventor 尹跳
Owner 广东赛珐生物科技有限公司
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