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Liquid preparation composition and preparation method and use and solid preparation thereof

A technology for liquid preparations and solid preparations, used in liquid delivery, drug combinations, pharmaceutical formulations, etc., can solve problems such as rapid relief, and achieve the effects of promoting recovery, reducing the probability of infection, and being easy to open.

Inactive Publication Date: 2016-03-30
SHENZHEN HIGHTIDE BIOPHARM +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in these treatment methods, except for surgery, none of them can quickly relieve the patient's discomfort symptoms such as earplugs, nasal congestion, pain, cough, wheezing, dry eyes, dry mouth and dry nose in a short period of time (minutes-hours).

Method used

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  • Liquid preparation composition and preparation method and use and solid preparation thereof

Examples

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Effect test

preparation example Construction

[0078] Simultaneously, the present invention also provides the preparation method of above-mentioned liquid preparation composition, comprises:

[0079] S1. Disperse the liquid surfactant in 40-60KHZ ultrasound for 1-3min;

[0080] S2. Under stirring conditions with a rotation speed of 3000 rpm or more, uniformly mix the liquid surfactant and the solvent to form a liquid formulation composition in which droplets containing the surfactant are dispersed in the solvent, and the surface tension of the liquid formulation composition is Less than 60mN / m, the absolute value of zeta potential is more than 15mV.

[0081] In the above-mentioned preparation method, for the surfactant, the specific materials that can be used are as mentioned above, which can be lecithin, sterol, pulmonary surfactant, poloxamer, dipalmitoylphosphatidylcholine, cholesterol, cholesteryl ester, One or more of phosphatidylethanolamine, phosphatidylglycerol, polyethylene glycol. The above-mentioned various su...

Embodiment 1

[0115] This example is used to illustrate the liquid preparation composition disclosed in the present invention and its preparation method.

[0116] Weigh 2.38 g of hydrogenated phospholipids, 0.12 g of sterols, 0.4 g of methylparaben, 0.2 g of ethylparaben and 0.1 g of menthol and place them in a container. Add 1ml of absolute ethanol, dissolve with ultrasound (40KHZ), mix well under high-speed stirring (6000rpm), continue to add water to a final volume of 100ml, mix well, pour into a sprayer or dropper, and seal. After testing the quality parameters such as appearance properties, loading capacity, main component content, per spray volume (or per drop volume), microbial limit, etc., it is packaged after meeting the requirements, and it is ready.

[0117] The surface tension of the final product was detected by an automatic surface tension tester (USKino, A601) to be 48.851mN / m. The particle size distribution of the product was measured with a laser particle size analyzer Mas...

Embodiment 2

[0120] This example is used to illustrate the liquid preparation composition disclosed in the present invention and its preparation method.

[0121] Weigh 2.35g of soybean lecithin, 0.15g of poloxamer, 0.08g of vitamin E and 0.5g of phenylethyl alcohol and place them in a container. Add 1ml of absolute ethanol, dissolve with ultrasound (40KHZ), stir evenly at high speed (6000rpm), continue to add water to a final volume of 100ml, mix evenly, pour into a sprayer or dropper, and seal. After testing the quality parameters such as appearance properties, loading capacity, main component content, per spray volume (or per drop volume), microbial limit, etc., it is packaged after meeting the requirements, and it is ready.

[0122] The surface tension of the final product was detected by an automatic surface tension tester (USKino, A601) to be 16.252mN / m. The particle size distribution of the product was measured by a laser particle size analyzer Mastersizer 2000 (Malvern Instruments ...

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Abstract

The present invention provides a liquid preparation composition, which is emulsion comprising a solvent and surfactant-containing liquid droplets distributed in the solvent, the volume average particle diameter of the liquid droplet is 100mum or less, the surface tension of the liquid preparation composition is less than 60mN / m, and the absolute value of the zeta potential is more than 15mV. The present invention also discloses a preparation method of the liquid preparation composition and use of the liquid preparation composition in treatment of otitis media, otitis externa, rhinitis, nasosinusitis, lower respiratory tract inflammation, xerostomia, xerophthalmia and dry noses. The present invention also discloses a preparation prepared from the liquid preparation composition. The liquid preparation composition can effectively relieve the otitis media, the otitis externa, the rhinitis, the nasosinusitis, the lower respiratory tract inflammation, the xerostomia, the xerophthalmia, the dry noses and other symptoms, can be used in the form of sprays or liquid droplets, can be applied to an effective site without use of a propellant or an atomization device, is easy to operate, and can effectively avoid stimulation and injury caused by the propellant and use inconvenience of the atomization device.

Description

technical field [0001] The present invention relates to a liquid preparation composition and a preparation method thereof, as well as the use of the liquid preparation composition and a solid preparation obtained from the liquid preparation composition. Background technique [0002] Otitis media, otitis externa, rhinitis and sinusitis are common ENT diseases. Among them, otitis media is an inflammatory lesion involving all or part of the structure of the middle ear (including the Eustachian tube, tympanic cavity, tympanic antrum, and mastoid air cells), and it is more common in children. Can be divided into non-suppurative and suppurative two categories. Non-suppurative cases include secretory otitis media and barotrauma otitis media (caused by changes in aircraft take-off and landing pressure, increased diving water pressure, etc.); suppurative cases can be divided into acute and chronic cases. Otitis externa (Otitis externa) is the inflammation of the external auditory c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K9/10A61P27/16A61P11/02A61P27/02A61P11/00
Inventor 于莉詹姆斯·格瑞·弗格森
Owner SHENZHEN HIGHTIDE BIOPHARM
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