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Preparation composition and preparation method and use thereof

A composition and preparation technology, applied in the field of preparation compositions and their preparation, can solve problems such as rapid relief, and achieve the effects of promoting recovery, eliminating tinnitus, and reducing the probability of infection

Inactive Publication Date: 2016-03-30
SHENZHEN HIGHTIDE BIOPHARM +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in these treatment methods, except for surgery, none of them can quickly relieve the patient's discomfort symptoms such as earplugs, nasal congestion, pain, cough, wheezing, dry eyes, dry mouth and dry nose in a short period of time (minutes-hours).

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0079] Simultaneously, the present invention also provides the preparation method of above-mentioned preparation composition, comprise:

[0080] S1. Disperse the liquid surfactant in 40-60KHZ ultrasound for 1-3min;

[0081]S2. Under stirring conditions with a rotation speed of 3000 rpm or more, uniformly mix liquid surfactants, pharmaceutical ingredients, and solvents to form a preparation composition in which droplets containing surfactants are dispersed in the solvent, and the surface of the preparation composition The tension is less than 60mN / m, and the absolute value of zeta potential is above 15mV;

[0082] The medicinal ingredients include one or more of medicines for treating rhinitis, sinusitis, lower respiratory tract inflammation, otitis media, otitis externa, xerostomia, xerophthalmia, and xerostomia.

[0083] In the above-mentioned preparation method, for the surfactant, the specific materials that can be used are as mentioned above, which can be lecithin, sterol...

Embodiment 1

[0117] This example is used to illustrate the preparation composition disclosed in the present invention (when no pharmaceutical ingredients have been added) and its preparation method.

[0118] Weigh 2.38 g of hydrogenated phospholipids, 0.12 g of sterols, 0.4 g of methylparaben, 0.2 g of ethylparaben and 0.1 g of menthol and place them in a container. Add 1ml of absolute ethanol, dissolve with ultrasound (40KHZ), mix well under high-speed stirring (6000rpm), continue to add water to a final volume of 100ml, mix well, pour into a sprayer or dropper, and seal. After testing the quality parameters such as appearance properties, loading capacity, main component content, per spray volume (or per drop volume), microbial limit, etc., it is packaged after meeting the requirements, and it is ready.

[0119] The surface tension of the final product was detected by an automatic surface tension tester (USKino, A601) to be 48.851mN / m. The particle size distribution of the product was me...

Embodiment 2

[0122] This example is used to illustrate the preparation composition disclosed in the present invention (when no pharmaceutical ingredients have been added) and its preparation method.

[0123] Weigh 2.35g of soybean lecithin, 0.15g of poloxamer, 0.08g of vitamin E and 0.5g of phenylethyl alcohol and place them in a container. Add 1ml of absolute ethanol, dissolve with ultrasound (40KHZ), stir evenly at high speed (6000rpm), continue to add water to a final volume of 100ml, mix evenly, pour into a sprayer or dropper, and seal. After testing the quality parameters such as appearance properties, loading capacity, main component content, per spray volume (or per drop volume), microbial limit, etc., it is packaged after meeting the requirements, and it is ready.

[0124] The surface tension of the final product was detected by an automatic surface tension tester (USKino, A601) to be 16.252mN / m. The particle size distribution of the product was measured by a laser particle size a...

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Abstract

The present invention provides a preparation composition comprising a solvent, a drug component and a surfactant, the preparation composition is emulsion, surfactant-containing liquid droplets are distributed in the solvent, the volume average particle diameter of the liquid droplet is 100mum or less, the drug component comprises one drug or more drugs for treatment of otitis media, otitis externa, rhinitis, nasosinusitis, lower respiratory tract inflammation, xerostomia, xerophthalmia and dry noses, the surface tension of the preparation composition is less than 60mN / m, and the absolute value of the zeta potential is more than 15mV. The present invention also discloses a preparation method and use of the preparation composition. The preparation composition can relieve the otitis media, the otitis externa, the rhinitis, the nasosinusitis, the lower respiratory tract inflammation, the xerostomia, the xerophthalmia, the dry noses and other symptoms, can be used in the form of sprays or liquid droplets, can be applied to an effective site without use of a propellant or an atomization device, is easy to operate, and can effectively avoid stimulation and injury caused by the propellant and use inconvenience of the atomization device.

Description

technical field [0001] The invention relates to a preparation composition, a preparation method thereof, and an application of the preparation composition. Background technique [0002] Otitis media, otitis externa, rhinitis and sinusitis are common ENT diseases. Among them, otitis media is an inflammatory lesion involving all or part of the structure of the middle ear (including the Eustachian tube, tympanic cavity, tympanic antrum, and mastoid air cells), and it is more common in children. Can be divided into non-suppurative and suppurative two categories. Non-suppurative cases include secretory otitis media and barotrauma otitis media (caused by changes in aircraft take-off and landing pressure, increased diving water pressure, etc.); suppurative cases can be divided into acute and chronic cases. Otitis externa (Otitis externa) is the inflammation of the external auditory canal infection, often caused by ear picking, ear scratching or sewage entering the external audito...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K45/00A61K47/24A61K47/34A61K47/28A61P27/16A61P11/02A61P27/02A61P1/02A61P11/00
Inventor 于莉詹姆斯·格瑞·弗格森
Owner SHENZHEN HIGHTIDE BIOPHARM
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