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Liquid preparation composition and preparation method and use and solid preparation thereof

A liquid preparation and composition technology, applied in the field of liquid preparation composition and its preparation, can solve problems such as rapid relief, and achieve the effects of promoting recovery, reducing ear pressure, and reducing the chance of infection

Inactive Publication Date: 2016-03-30
SHENZHEN HIGHTIDE BIOPHARM +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in these treatment methods, except for surgery, none of them can quickly relieve the patient's discomfort symptoms such as earplugs, nasal congestion, pain, cough, wheezing, dry eyes, dry mouth and dry nose in a short period of time (minutes-hours).

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] This example is used to illustrate the liquid preparation composition disclosed in the present invention and its preparation method.

[0092] Weigh 0.1 g of poloxamer (188) and 0.8 mg of phenylethyl alcohol and place them in a container. Add water to a final volume of 100ml, mix well, pour into a sprayer or dropper, and seal. After testing the quality parameters such as appearance properties, loading capacity, main component content, per spray volume (or per drop volume), microbial limit, etc., it is packaged after meeting the requirements, and it is ready.

[0093] The surface tension of the final product was detected by an automatic surface tension tester (USKino, A601) to be 25.851mN / m. The pH value of the product was measured with a pH meter (Shanghai Leici, PHSJ3F), and the result was 5.7.

Embodiment 2

[0095] This example is used to illustrate the liquid preparation composition (including the medicine for treating rhinitis and sinusitis) disclosed in the present invention and its preparation method.

[0096] Weigh 0.1 g of poloxamer (188), 0.8 mg of phenylethyl alcohol, and 60 mg of dexamethasone sodium phosphate (based on dexamethasone) and place them in a container, add 10 ml of water to dissolve completely. Add the above mixed solution into Tris-citric acid buffer solution with pH 6.5 to a final volume of 100ml, mix well, pour into a sprayer or a dropper, and seal it. After testing the quality parameters such as appearance properties, loading capacity, main component content, per spray volume (or per drop volume), microbial limit, etc., it is packaged after meeting the requirements, and it is ready.

[0097] The surface tension of the final product was detected by an automatic surface tension tester (USKino, A601) to be 25.512mN / m. The pH value of the product was measure...

Embodiment 3

[0099] This example is used to illustrate the liquid preparation composition (containing otitis media treatment medicine) disclosed in the present invention and its preparation method.

[0100] Weigh 0.1 g of poloxamer (188) and 0.3 g of levofloxacin hydrochloride (calculated as levofloxacin) and place them in a container, add 10 ml of water to dissolve completely. Add the above mixed solution into HEPES buffer solution with pH 6.0 to a final volume of 100ml, mix well, pour into an anti-pollution delivery device (OSD), and seal it. After testing the quality parameters such as appearance properties, loading capacity, main component content, per spray volume (or per drop volume), microbial limit, etc., it is packaged after meeting the requirements, and it is ready.

[0101] The surface tension of the final product was detected by an automatic surface tension tester (USKino, A601) to be 24.125mN / m. The pH value of the product was measured with a pH meter (Shanghai Leici, PHSJ3F)...

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Abstract

The present invention provides a liquid preparation composition comprising a solvent and a surfactant dissolving in the solvent, the surface tension of the liquid preparation composition is less than 60mN / m, and the pH of the liquid preparation composition is 5.0-7.4. The present invention also discloses a preparation method of the liquid preparation composition and use of the liquid preparation composition in treatment of otitis media, otitis externa, rhinitis, nasosinusitis, lower respiratory tract inflammation, xerostomia, xerophthalmia and dry noses. The present invention also discloses a preparation comprising the liquid preparation composition. The liquid preparation composition can effectively relieve the otitis media, the otitis externa, the rhinitis, the nasosinusitis, the lower respiratory tract inflammation, the xerostomia, the xerophthalmia, the dry noses and other symptoms, can be used in the form of sprays or liquid droplets, can be applied to an effective site without use of a propellant or an atomization device, is easy to operate, and can effectively avoid stimulation and injury caused by the propellant and use inconvenience of the atomization device.

Description

technical field [0001] The present invention relates to a liquid preparation composition and a preparation method thereof, as well as the use of the liquid preparation composition and preparations comprising the liquid preparation composition. Background technique [0002] Otitis media, otitis externa, rhinitis and sinusitis are common ENT diseases. Among them, otitis media is an inflammatory lesion involving all or part of the structure of the middle ear (including the Eustachian tube, tympanic cavity, tympanic antrum, and mastoid air cells), and it is more common in children. Can be divided into non-suppurative and suppurative two categories. Non-suppurative cases include secretory otitis media and barotrauma otitis media (caused by changes in aircraft take-off and landing pressure, increased diving water pressure, etc.); suppurative cases can be divided into acute and chronic cases. Otitis externa (Otitis externa) is the inflammation of the external auditory canal infec...

Claims

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Application Information

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IPC IPC(8): A61K47/00A61K45/00A61P19/02A61P27/16A61P11/00A61P1/02A61P27/02
Inventor 于莉詹姆斯·格瑞·弗格森
Owner SHENZHEN HIGHTIDE BIOPHARM
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