Liquid preparation composition and preparation method and use and solid preparation thereof

Abstract

The present invention provides a liquid preparation composition comprising a solvent and a surfactant dissolving in the solvent, the surface tension of the liquid preparation composition is less than 60mN / m, and the pH of the liquid preparation composition is 5.0-7.4. The present invention also discloses a preparation method of the liquid preparation composition and use of the liquid preparation composition in treatment of otitis media, otitis externa, rhinitis, nasosinusitis, lower respiratory tract inflammation, xerostomia, xerophthalmia and dry noses. The present invention also discloses a preparation comprising the liquid preparation composition. The liquid preparation composition can effectively relieve the otitis media, the otitis externa, the rhinitis, the nasosinusitis, the lower respiratory tract inflammation, the xerostomia, the xerophthalmia, the dry noses and other symptoms, can be used in the form of sprays or liquid droplets, can be applied to an effective site without use of a propellant or an atomization device, is easy to operate, and can effectively avoid stimulation and injury caused by the propellant and use inconvenience of the atomization device.

Description

technical field

[0001] The present invention relates to a liquid preparation composition and a preparation method thereof, as well as the use of the liquid preparation composition and preparations comprising the liquid preparation composition. Background technique

[0002] Otitis media, otitis externa, rhinitis and sinusitis are common ENT diseases. Among them, otitis media is an inflammatory lesion involving all or part of the structure of the middle ear (including the Eustachian tube, tympanic cavity, tympanic antrum, and mastoid air cells), and it is more common in children. Can be divided into non-suppurative and suppurative two categories. Non-suppurative cases include secretory otitis media and barotrauma otitis media (caused by changes in aircraft take-off and landing pressure, increased diving water pressure, etc.); suppurative cases can be divided into acute and chronic cases. Otitis externa (Otitis externa) is the inflammation of the external auditory canal infec...