Artificial saliva

A technology of artificial saliva and aqueous solution, applied in the field of artificial saliva, can solve the problems of artificial saliva such as short action time, easy dental caries, and lower quality of life of patients, and achieve the effects of good product stability, improved quality of life, and good taste

Active Publication Date: 2009-09-09
SHENZHEN SOUTH CHINA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The lack of saliva in patients with xerostomia will cause strong discomfort of dry mouth, and at the same time, it is easy to cause damage to oral soft tissues, prone to dental caries and other oral diseases, and may cause a series of problems such as speech barriers and anorexia, causing great harm to patients. Inconvenient, greatly reducing the patient's quality of life
[0004] In response to the above problems, some artificial saliva products are currently on the market abroad, and there are som

Method used

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  • Artificial saliva

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] prescription composition

[0075] Sodium chloride 0.0844%

[0076] Potassium chloride 0.12%

[0077] Calcium chloride 0.0146%

[0078] Magnesium chloride 0.0052%

[0079] Dipotassium hydrogen phosphate 0.0342%

[0080] HPMC K4M 0.1%

[0081] Xylitol 2%

[0082] Sodium Benzoate 0.1%

[0083] Peppermint Oil 0.01%

[0084] Appropriate amount of water

[0085] Preparation:

[0086] Take other ingredients except HPMC, add water to dissolve and stir evenly, add HPMC K4M while stirring, after completely dissolving, add sodium hydroxide to adjust pH to 6.0, fill in a spray bottle, and obtain artificial saliva spray.

Embodiment 2

[0088] prescription composition

[0089] Sodium chloride 0.0844%

[0090] Potassium chloride 0.12%

[0091] Calcium chloride 0.0146%

[0092] Magnesium chloride 0.0052%

[0093] Dipotassium hydrogen phosphate 0.0342%

[0094] HPMC K4M 0.15%

[0095] Xylitol 3.5%

[0096] Sodium Benzoate 0.2%

[0097] Orange flavor 0.01%

[0098] Appropriate amount of water

[0099] Preparation method: with embodiment 1.

Embodiment 3

[0101] prescription composition

[0102] Sodium chloride 0.0844%

[0103] Potassium chloride 0.12%

[0104] Calcium chloride 0.0146%

[0105] Magnesium chloride 0.0052%

[0106] Dipotassium hydrogen phosphate 0.0342%

[0107] HPMC K4M 0.2%

[0108] Xylitol 1%

[0109] Sodium Benzoate 0.02%

[0110] Methylparaben 0.1%

[0111] Apple Flavor 0.01%

[0112] Appropriate amount of water

[0113] Preparation method: with embodiment 1.

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Abstract

The invention relates to artificial saliva, which comprises a plurality of inorganic salt, HPMC, a preservative, a flavoring agent and other components. The artificial saliva has the following advantages that: (1) the artificial saliva can rapidly improve symptoms of a patient suffering from xerostomia, and can maintain the function in a longer period; (2) the artificial saliva has good stability; and (3) the artificial saliva has a good mouthfeel when in use.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to artificial saliva for preventing and treating xerostomia and improving xerostomia and related symptoms. technical background [0002] Sjogren's syndrome is an autoimmune disease characterized by high lymphocyte infiltration of exocrine glands. The most common symptom is dry mouth and eyes, but its clinical manifestations are far from limited to this, but a systemic disease. It may be involved, and kidney involvement is very common. Sjögren's syndrome occurs the most in autoimmune rheumatic diseases, and malignant lymphoproliferation is another feature. It is a chronic immune disease. There are two types of it: primary and secondary, with a prevalence rate of 0.29% to 0.77%, mostly after middle age, with a high incidence between 45 and 55 years old, and 90% of them are women. Xerostomia is one of the important components of Sjogren's syndrome. [0003] The ...

Claims

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Application Information

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IPC IPC(8): A61K31/717A61K33/42A61K9/12A61K9/08A61K47/26A61K47/22A61K47/14A61K47/12A61K47/10A61P1/02A61K33/14A61K33/06
Inventor 苏宏瑞卢锦华
Owner SHENZHEN SOUTH CHINA PHARMA
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