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Sialogogue and, containing the same, oral composition and food composition

The technology of a salivation-promoting agent and composition is applied in the field of oral compositions, which can solve the problems of promoting saliva secretion, lack of confirmation, and limitation of use, and achieve the effect of preventing dental caries and high safety.

Inactive Publication Date: 2006-12-20
MEIJI SEIKA KAISHA LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, although hyaluronic acid has a moisturizing effect, it has not been confirmed that it actively promotes saliva secretion
On the other hand, the above-mentioned sialotropes have a somewhat taste, so their use is limited

Method used

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  • Sialogogue and, containing the same, oral composition and food composition
  • Sialogogue and, containing the same, oral composition and food composition
  • Sialogogue and, containing the same, oral composition and food composition

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0050] Experimental example 1 salivation effect

[0051] Test mouthwash containing 0.1% of γ-polyglutamate and sodium hyaluronate each were adjusted with water, and the salivation effect was evaluated by the following method.

[0052] Salivation evaluation test method:

[0053] Three test group members who were thirsty due to intense exercise the day before the test were selected, and the amount of saliva secretion was measured for the test members in the following order.

[0054] (1) Gargle with 20 mL of normal saline for 30 seconds.

[0055] (2) Then, the saliva was spit into the spittoon processor, and at the same time, the accumulated amount of saliva was measured every 5 minutes for 30 minutes.

[0056] (3) Then, rinse the mouth with 20 mL of the test solution for 30 seconds.

[0057] (4) The accumulated saliva volume for 30 minutes is measured again in the same manner as (2).

[0058] Table 1 shows the average rate of increase in saliva secretion after gargling with ...

experiment example 2

[0061] Experimental example 2 moist feeling and taste intensity

[0062] A 0.1% aqueous solution of each sample shown in Table 2 was prepared, and three test members rinsed their mouths with 20 mL of each solution for 30 seconds and spit it out. Table 2 shows the evaluation results obtained from the total scores of the three test members based on the evaluation of the intensity of mouth moist feeling and the refreshing feeling in the mouth after 15 minutes based on the following criteria.

[0063] Tested sample

[0064] *Using the same γ-polyglutamic acid as Experiment 1

[0065] Evaluation of Moisture Intensity

[0066] intensity

[0067] total score

[0068] intensity

Embodiment 1

[0070] Example 1 Toothpaste

[0071] Precipitated silica 25.00%

[0072] Glycerin 25.00

[0073] Sorbitol 15.00

[0074] Xylitol 10.00

[0075] Lauroyl Decacylglyceride 1.00

[0076] Diethanolamide myristate

[0077] (myristic acid diethanol amide) 2.00

[0078] Spice 1.00

[0079] Sodium saccharin 0.20

[0080] Potassium γ-polyglutamate (Mw1 million) 0.10

[0081] Purified water the rest

[0082] Total 100.0%

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Abstract

A sialogogue characterized by comprising polyglutamic acid or its salt. This sialogogue is blended into an oral composition and a food product. This sialogogue is capable of rendering the oral mucosa pleasant even in the case of severe xerostomia.

Description

technical field [0001] The present invention relates to a salivation agent for treating xerostomia, an oral composition mixed with the salivation agent, and a food composition. Background technique [0002] People experience dry mouth on a daily basis, accompanied by sticky discomfort, difficulty speaking, and bad breath. If it further develops into a disease, the flora in the oral cavity will change, resulting in oral dysfunction such as dental caries, periodontal disease, and mucosal infection. Therefore, to keep the mouth fresh and prevent oral diseases, it is very important to promote saliva secretion and make the mouth moist. [0003] Therefore, in order to keep the oral cavity fresh and prevent oral diseases, it is necessary to moisten the oral cavity. For example, WO 00 / 56344 has proposed the use of hyaluronic acid as a humectant. In addition, it has also been proposed to actively promote the secretion of saliva to moisten the mouth. For example, in JP-A-56-22719 an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/785A23L1/30A61K8/84A61P1/02A61Q11/00A61K8/88A61Q11/02
CPCA61Q11/00A23L1/30A61K8/88A61K31/785A61Q11/02A23L33/10A61P1/02
Inventor 鱼谷和道窪田英俊远藤裕也常田文彦
Owner MEIJI SEIKA KAISHA LTD
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