The invention discloses a fluorescent probe for detecting
fluorine ions in living cells and a method for preparing the fluorescent probe. The fluorescent probe is of a structure shown as a formula I. The fluorescent probe and the method have the advantages that the fluorescent probe is nearly free of optional
fluorescent light, but Si-O bonds can be broken under induction of the
fluorine ions, TBDPS (tert-butyl diphenyl
silicon-based) protecting groups can be removed, phenolic hydroxy can be generated, HPQ (hydroxypiperaquine) can be released, accordingly, effects of transferring protons in excited-state molecules can be realized, phenomena of greatly enhancing
fluorescent light can occur, and strategies for detecting the
fluorine ions by means of
fluorescent light 'turn-on' can be implemented; the phenomena of enhancing the fluorescent light of the probe can be observed by naked eyes under illumination of
ultraviolet lamps when the fluorine ions have the low concentration of 20 micro-M, the fluorescent probe is excellent in
biocompatibility, can be permeated through
cell membranes and can be combined with
laser confocal microscopes, and accordingly response of the fluorescent probe to the micromole-level fluorine ions in the living cells can be observed; the method for synthesizing the fluorescent probe is simple, post-treatment is simple and convenient, and ultimate products with high yields can be obtained without column chromatographic purification.