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Oil-soluble/water-soluble organic-inorganic three-phase porous micro-nanometer composite bone repair material

A three-phase porous, micro-nano composite technology, used in medical science, prosthesis and other directions, can solve the problems of insufficient compressive strength and bending strength, poor mechanical properties, etc., to enhance physical and chemical properties, improve matrix properties, and improve materials. performance effect

Active Publication Date: 2015-06-17
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mechanical properties of pure nHAp particles are poor, brittle, and the compressive strength and bending strength are not enough. In order to improve its instability, it is necessary to prepare composite materials by organic-inorganic methods in order to obtain high strength and better biocompatibility. Bone tissue scaffold materials meet biomedical needs

Method used

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  • Oil-soluble/water-soluble organic-inorganic three-phase porous micro-nanometer composite bone repair material
  • Oil-soluble/water-soluble organic-inorganic three-phase porous micro-nanometer composite bone repair material
  • Oil-soluble/water-soluble organic-inorganic three-phase porous micro-nanometer composite bone repair material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The chitosan / fish skin collagen / polylactic acid composite scaffold is made of the following components by mass percentage:

[0039] Chitosan 2.0%

[0040] Fish Skin Collagen 0.2%

[0041] Polylactic acid 0.1%

[0042] Hydroxyapatite 1.2%

[0043] The balance is deionized water.

[0044] 1) Dissolve a certain amount of chitosan and collagen in 1% (v / v) acetic acid solution according to the above ratio, and dissolve a certain amount of polylactic acid in 1,4-dioxane, and mix well;

[0045] 2) Prepare 2mol / L calcium nitrate solution and 1.2mol / L dipotassium hydrogen phosphate solution, add a certain volume of soluble Calcium salt and soluble phosphate solution, the two are added at intervals of 20 minutes;

[0046] 3) Slowly add the polylactic acid solution to the chitosan / collagen acetic acid solution and stir for 1 hour to make it fully mixed;

[0047] 4) Then add a certain amount of cross-linking agent for cross-linking, and cross-link at room temperature for 5 ho...

Embodiment 2

[0051] The chitosan / fish skin collagen / polylactic acid composite scaffold is made of the following components by mass percentage:

[0052] Chitosan 2.0%

[0053] Fish Skin Collagen 0.2%

[0054] Polylactic acid 0.2%

[0055] Hydroxyapatite 1.2%

[0056] The balance is deionized water.

[0057] 1) Dissolve a certain amount of chitosan and collagen in 1% (v / v) acetic acid solution according to the above ratio, and dissolve a certain amount of polylactic acid in 1,4-dioxane, and mix well;

[0058] 2) Prepare 2mol / L calcium nitrate solution and 1.2mol / L dipotassium hydrogen phosphate solution, add a certain volume of soluble Calcium salt and soluble phosphate solution, the two are added at intervals of 20 minutes;

[0059] 3) Slowly add the polylactic acid solution to the chitosan / collagen acetic acid solution and stir for 1 hour to make it fully mixed;

[0060] 4) Then add a certain amount of cross-linking agent for cross-linking, and cross-link at room temperature for 5 ho...

Embodiment 3

[0064] The chitosan / fish skin collagen / polylactic acid composite scaffold is made of the following components by mass percentage:

[0065] Chitosan 2.0%

[0066] Fish Skin Collagen 0.2%

[0067] Polylactic acid 0.3%

[0068] Hydroxyapatite 1.2%

[0069] The balance is deionized water.

[0070] 1) Dissolve a certain amount of chitosan and collagen in 1% (v / v) acetic acid solution according to the above ratio, and dissolve a certain amount of polylactic acid in 1,4-dioxane, and mix well;

[0071] 2) Prepare 2mol / L calcium nitrate solution and 1.2mol / L dipotassium hydrogen phosphate solution, add a certain volume of soluble Calcium salt and soluble phosphate solution, the two are added at intervals of 20 minutes;

[0072] 3) Slowly add the polylactic acid solution to the chitosan / collagen acetic acid solution and stir for 1 hour to make it fully mixed;

[0073] 4) Then add a certain amount of cross-linking agent for cross-linking, and cross-link at room temperature for 5 ho...

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Abstract

The invention discloses an oil-soluble / water-soluble organic-inorganic three-phase porous micro-nanometer composite bone repair material and a preparation method thereof. From the bionic angle, for better simulating the components, structure and function of natural bone tissues, chitosan and collagen are selected as water-soluble organic matrixes; an oil-soluble high-molecular material polylactic acid is added for improving the performance; a water-soluble phase can be combined with an oil-soluble phase by crosslinking; an in-situ crystallization process of inorganic calcium and phosphorus mineral in the natural bone tissues under the regulation and control of organic matrix biological large molecules is simulated by a hybridization method; a nanometer hydroxyapatite crystal is synthesized on the matrix; an artificial bone defect repair scaffold similar to natural bone extracellular matrix is molded and prepared by utilizing a freeze-drying phase separation technology. The preparation method of the oil-soluble / water-soluble organic-inorganic three-phase porous micro-nanometer composite bone repair material disclosed by the invention is simple in procedures and mild in condition; the prepared composite scaffold is similar to natural bone matrix in constitution and structure, has a typical micro-nanometer structure (micrometer-grade hole diameter size and nanometer crystal), is excellent in performance and high in figurability and can be processed into required shapes.

Description

technical field [0001] The invention belongs to the field of bone tissue repair scaffold material manufacturing, and in particular relates to an oil-soluble / water-soluble organic-inorganic three-phase porous micro-nano composite bone repair material and a preparation method thereof. Background technique [0002] The basic components of natural bone include water, calcium phosphate minerals mainly composed of apatite and organic matrix mainly composed of collagen fibers. The nucleation, growth, crystal form, orientation, size, shape, and orderly arrangement of nanoscale calcium phosphate minerals in bone are regulated by organic matrix templates, which have unique properties. The diameter of collagen fibers is between 50 and 500 nm. The organic matrix composed of nanofibers not only regulates the mineralization process, but also affects cell adhesion, proliferation, migration, differentiation, etc. through the interaction with cells. Behavior. Based on these nanoscale struc...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/56A61L27/58
Inventor 陈景帝张玉珏范田堂张其清
Owner FUZHOU UNIV
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