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Method for synthesizing hydroxyapatite crystals

A technology for synthesizing hydroxyapatite and hydroxyapatite, applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., can solve problems such as irregular crystal shape, difficult crystal plane control, and uneven particle size, and achieve The effect of low cost, convenient operation and simple preparation process

Inactive Publication Date: 2013-11-20
SOUTHWEAT UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Its advantage is that the reaction can increase the growth rate of the crystal, and the crystal yield is also high. Its disadvantage is that it is difficult to modify the crystal surface by using a single surfactant (usually only disodium ethylenediaminetetraacetic acid is used as an organic modifier). Control, irregular crystal shape, uneven particle size, poor product quality, usually only one-dimensional rods or three-dimensional whiskers can be obtained

Method used

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  • Method for synthesizing hydroxyapatite crystals
  • Method for synthesizing hydroxyapatite crystals

Examples

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Effect test

Embodiment 1

[0030] Ca(NO 3 ) 2 4H 2 O makes it dissolve, disodium edetate and Ca(NO 3 ) 2 The molar ratio of the stearic acid is 1:2, and the mass fraction of stearic acid is 5%. Then (NH 4 ) 2 HPO 4 The solution was added to the above solution. Ca(NO 3 ) 2 4H 2 O and (NH 4 ) 2 HPO 4 The molar ratio is 5:3. The pH value of the reaction solution was adjusted to 9 with ammonia water, and stirred at constant temperature for 2 hours. Afterwards, the solution was added into a stainless steel hydrothermal synthesis kettle lined with a polytetrafluoroethylene liner, and reacted at 140° C. for 20 hours to obtain a white precipitate. The white precipitate was suction filtered, washed, and freeze-dried for 24 hours to obtain the target product. figure 1 For the infrared spectrogram of the hydroxyapatite prepared in this embodiment, in the IR spectrum, 3568cm ?1 and 628 cm ?1 The peak is the characteristic peak of hydroxyl (OH), 871 cm ?1 is HPO 4 2? peak at 1400 cm ?1 and 1500...

Embodiment 2

[0032] Ca(NO 3 ) 2 4H 2 O makes it dissolve, disodium edetate and Ca(NO 3 ) 2 The molar ratio of the stearic acid is 1:2, and the mass fraction of stearic acid is 10%. Then (NH 4 ) 2 HPO 4 The solution was added to the above solution. Ca(NO 3 ) 2 4H 2 O and (NH 4 ) 2 HPO 4 The molar ratio is 5:3. The pH value of the reaction solution was adjusted to 10 with ammonia water, and stirred at constant temperature for 2 hours. Afterwards, the solution was added to a stainless steel hydrothermal synthesis kettle lined with a polytetrafluoroethylene liner, and reacted at 140° C. for 16 hours to obtain a white precipitate. The white precipitate was suction-filtered, washed, and freeze-dried for 24 hours to obtain the target product.

Embodiment 3

[0034] Ca(NO 3 ) 2 4H 2 O makes it dissolve, disodium edetate and Ca(NO 3 ) 2 The molar ratio of the stearic acid is 1:1, and the mass fraction of stearic acid is 20%. Then (NH 4 ) 2 HPO4 The solution was added to the above solution. Ca(NO 3 ) 2 4H 2 O and (NH 4 ) 2 HPO 4 The molar ratio is 5:3. The pH value of the reaction solution was adjusted to 11 with ammonia water, and stirred at constant temperature for 2 hours. Afterwards, the solution was added into a stainless steel hydrothermal synthesis kettle lined with a polytetrafluoroethylene liner, and reacted at 120° C. for 20 hours to obtain a white precipitate. The white precipitate was suction-filtered, washed, and freeze-dried for 24 hours to obtain the target product.

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Abstract

The invention discloses a method for synthesizing hydroxyapatite crystals under the control of an organic molecule template. The method comprises the following steps of: by using Ca(NO3)2.4H2O and (NH4)2HPO4 as raw materials and water and alcohol as solvents, adding ethylenediamine tetraacetic acid disodium and stearic acid serving as additives, adjusting pH in the range from 7 to 11, and carrying out thermostatic reaction for 0.5-2 hours at 40-90 DEG C; afterwards, adding the solution to a stainless steel hydrothermal synthesis kettle with a polytetrafluoroethylene inner container, and reacting for 10 to 24 hours at 120 to 190 DEG C; after completion of reaction, obtaining white precipitates; carrying out suction filtration of white precipitates, and washing to obtain the hexagonally prismatic hydroxyapatite crystals. The products obtained by the method have few agglomerates and high purity, are uniform in particle sizes, regular and controllable in shape and low in production cost and can be applied to the field of biomedical science.

Description

technical field [0001] The invention relates to a method for preparing hydroxyapatite crystals, in particular to a method for preparing hexagonal prism-shaped hydroxyapatite crystals with high aspect ratios under different reaction conditions by adding surfactants. Background technique [0002] Hydroxyapatite [HAP, Ca 10 (PO 4 ) 6 (OH) 2 ], its crystal is hexagonal crystal system, it is the main inorganic component of human and animal bones and teeth, has good biological activity and biocompatibility, can form a strong chemical combination with bone tissue, and is the main component of human bones and teeth The main alternative material. It has good remineralization performance, can exist stably in organisms, and is non-toxic and non-irritating. It can be used as biological tissue fillers, bone materials, etc., and has important functions in the fields of medical, catalysis, and environmental functional materials. . [0003] A lot of work has been done on the regulat...

Claims

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Application Information

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IPC IPC(8): C01B25/32
Inventor 沈娟金波蒋琪英
Owner SOUTHWEAT UNIV OF SCI & TECH
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