60 results about "Apatite crystals" patented technology

A complete bleaching unit is made up of an electrochemical system, finding its application in particular in the dental and medical fields, allowing, thanks to the creation of an electrophoretic field, a strong, fast penetration and directing the bleaching agents, their removal under the same conditions together with the molecules responsible for coloration and an effective and controlled penetration of the stabilizing agents for the apatite crystal, basic component of the tooth, such as fluorine. Also thanks to its light-based optical system, the invention provides that the activation of the photosensitive bleaching products by decreasing the heat effect while increasing the photonic effect thanks to a selection of wavelength in the range of 400-500 nm and, finally, thanks to an electro-optical unit, the control of the evolution of coloration by objective spectrocolorimetry-based methods.

The photocatalytic apatite composition and its production method are disclosed. The photocatalytic apatite comprises a photocatalytic apatite having incorporated into the apatite crystal structure thereof a metal oxide having a photocatalytic action, such as titanium oxide, and a metal ion having an antimicrobial property, such as a silver ion or a copper ion. The photocatalyst apatite composition is capable of maintaining excellent decomposition and adsorption properties for various organic materials such as VOCs or specific adsorbing substances such as a virus for a long time and, at the same time, expressing an excellent antimicrobial property in a dark place as well as under daylight.

A composite tissue-engineered porous scaffold material is prepared from the nano-class hydroxy phosphorite particles, medical polyamide and foaming agent through proportionally mixing, heating to fuse it, injection moulding under 30-50 MPa to form porous scaffold, and removing the surficial layer to open the pores. Its advantage is high mechanical performance.

The invention provides a preparation method of a superhydrophobic hydroxyapatite film layer on the surface of magnesium alloy. The preparation method comprises the following steps: performing surfacepretreatment, preparing a nano-structured hydroxyapatite layer by a hydrothermal method and performing hydrophobization treatment to the hydroxyapatite layer. The hydrothermal method is designed, andby the hydrothermal method, a rod-shaped hydroxyapatite crystal layer adopting micron-scale length and nano-scale diameter is prepared on the surface of the magnesium alloy, then a stearic acid film is prepared on the surface of the nano-structured hydroxyapatite film layer to form a superhydrophobic film layer with the contact angle of 153 degrees under a static droplet, the film layer can reducethe corrosion current density of the magnesium alloy by 2 orders of magnitude and the impedance modulus of coating is increased from 2029 Omega.cm2 to 117674 Omega.cm2. The preparation method of thenano-structured hydrophobic coating is simple, equipment is simple and easy to control, the cost is low, and the controllability is good; the preparation method is suitable for large-scale production.

The invention discloses a method for regenerating a dental prosthetic material and an acidic amino acid-induced demineralized dental enamel outer enamel prism thereof in situ, and belongs to the technical field of in-situ regeneration of dental enamel outer enamel prisms. The preparation method is as follows: firstly, carrying out surface calcium activation onto a dental enamel surface, i.e., grafting calcium ions; then, forming calcium carbonate stable calcium ions step by step; finally, taking calcium carbonate stable calcium ions as foundation forms to synthesize hydroxyapatite crystals. Amino acid participates in the whole process, concentration of the amino acid added in a two-step process is consistent. The hydroxyapatite crystals deposited on the surface of the demineralized dental enamel are orderly and compact in sequence, and uniform in crystal morphology, so that obvious continued growth tendency of an artificial layer can be seen. The preparation method disclosed by the invention lowers protein extracting cost and harsh restrictions on an application environment, and is wide in prospect. The material prepared by the method disclosed by the invention can be applied to cosmetic dental for filling demineralization gaps, also can be used for repairing early-stage enamel demineralization, and can be used as a combined material for bottom pulp capping pit and fissure sealing, and the like.

The invention discloses a method for synthesizing hydroxyapatite crystals under the control of an organic molecule template. The method comprises the following steps of: by using Ca(NO3)2.4H2O and (NH4)2HPO4 as raw materials and water and alcohol as solvents, adding ethylenediamine tetraacetic acid disodium and stearic acid serving as additives, adjusting pH in the range from 7 to 11, and carrying out thermostatic reaction for 0.5-2 hours at 40-90 DEG C; afterwards, adding the solution to a stainless steel hydrothermal synthesis kettle with a polytetrafluoroethylene inner container, and reacting for 10 to 24 hours at 120 to 190 DEG C; after completion of reaction, obtaining white precipitates; carrying out suction filtration of white precipitates, and washing to obtain the hexagonally prismatic hydroxyapatite crystals. The products obtained by the method have few agglomerates and high purity, are uniform in particle sizes, regular and controllable in shape and low in production cost and can be applied to the field of biomedical science.

Nano level osteolith crystal is prepared through reaction of calcium salt and alkali metal phosphate dissolved in acetamide or formamide medium containing water in 0-50 vol%. The material calcium salt and alkali metal phosphate are in such amount that the molar ratio between calcium and phosphor is 1.50-1.67, during the reaction, one kind of solution is dropped into the other solution, and after finishing the reaction and through aging for 24 hr, the deposit is washed with deionized water to obtain the slurry of the osteolith crystal. The prepared nano level osteolith crystal is similar to natural osteolith crystal and has excellent biological activity and thus may be used in preparing inorganic / organic nano composite bone repairing and replacing material.

The invention provides an environment-friendly inorganic soil solidification additive which comprises, by mass, 15-65% of sulfate, 15-65% of halide salt, 11-40% of phosphate, 5-30% of silicate, 0-25% of carbonate, 0-18% of basic oxide and 0-10% of lignosulfonate. The environment-friendly inorganic soil solidification additive is characterized in that all components in soil directly or indirectly undergo soil particle surface chemical modification and modification of substances among soil particles, and generation of colloidal gel materials and generation of various materials of crystal structures are promoted. As time goes, hardened skeletons such as ettringite needle-shaped crystals and apatite crystals appear gradually in solidified soil, soil solidification compressive strength, hydrophobicity, water permeability, stability of heavy metal and other harmful materials and other physical and chemical solidification effects are good, and the environment-friendly inorganic soil solidification additive can adapt to various climates, geographies and soil properties and is high in compatibility and obvious in stabilization and solidification effect on heavy metal and other harmful materials.

A method for electrochemically depositing discrete regions of calcium phosphate onto a medical implant. The method includes providing an implant including at least one area having a metallic surface. At least a portion of the metallic surface is contacted with an electrolyte solution comprising calcium ions and phosphate ions. The metallic surface is used as a cathode, and an electrical potential is applied between the cathode and the electrolyte solution. The electrical potential is applied with a constant current density of from about 10 to about 50 mA / cm2 for a period of time of from about 1 to about 20 minutes. A plurality of discrete regions of needle-shaped hydroxyapatite crystals are electrochemically deposited onto the metallic surface.

The invention discloses a tissue-engineered bone cartilage composite scaffold and a preparation method thereof, belonging to the technical field of biomaterials. The scaffold is of a multilayer integrated structure and comprises a cartilage tissue scaffold layer, a cartilage tissue calcified layer, a porous cell isolation membrane and a bone tissue scaffold layer. The cartilage tissue scaffold layer is inoculated with cartilage cells, and growth factors for promoting formation of cartilage are introduced to promote growth of cartilage cells. Main raw materials like heparan sulfate proteoglycan with good biocompatibility and degradability are selected and used and the method consisting of a cross-linking reaction, freeze drying, directional pore formation, compounding of multiple layers, overall integration and the like are carried out so as to obtain the functionalized multilayer integrated tissue-engineered bone cartilage composite scaffold with good mechanical properties. According to the invention, micro-nano hydroxyapatite crystal, degradable non-stoichiometric polyethylene glycol / poly(epsilon-caprolactone) nanometer coaxial short fiber, RGD-grafted heparan sulfate proteoglycan / oxidized sodium alginate and N-succinyl chitosan are compounded together to prepare the composite scaffold; and the composite scaffold is mainly used for restoration of full-thickness defects of articular cartilage and subchondral bone.

The invention discloses a method for induction of remineralization of tissue of tooth, which comprises the following steps: preparing a dental film; preparing a dentin remineralization inducing mineralization system solution; and remineralizing the dentin. In the invention, the micro environment of the calcification of the tissue of the tooth in a gel matrix is stimulated, a calcium phosphate ion dispersing hydrogel system is constructed, and the biomimetic mineralization of the dentin is induced in vitro. The surface deposits are qualitatively characterized by constructing an agar gel mineralization system on the surface of the acid-corroded dentin in vitro and by suing a scanning electron microscope (SEM) and a micro-Fourier transform infrared spectrometer (FTIR). Results show an agar gel CaCl2 solution mineralization system containing phosphate can induce the deposition and growth of strip nano crystals on the surface of acid-corroded dentin surface, and that the deposited apatite crystals are densely arranged in an interlaced shape. The method is simple, convenient, quick and low in cost, and is an effective technical method for the biomimetic mineralization of the dentin.

The photocatalytic apatite composition and its production method are disclosed. The photocatalytic apatite comprises a photocatalytic apatite having incorporated into the apatite crystal structure thereof a metal oxide having a photocatalytic action, such as titanium oxide, and a metal ion having an antimicrobial property, such as a silver ion or a copper ion. The photocatalyst apatite composition is capable of maintaining excellent decomposition and adsorption properties for various organic materials such as VOCs or specific adsorbing substances such as a virus for a long time and, at the same time, expressing an excellent antimicrobial property in a dark place as well as under daylight.

A new adsorbent of a porous mineral oxide material with apatite crystals, preferably hydroxyapatite crystals, in the pores of the mineral oxide material is disclosed. The adsorbent is useful for protein and nucleic acid separations

The present invention relates to a chewing gum comprising at least one gum base system, at least one chewing gum additive, and further comprising rod-shaped apatite crystals of the formula Ca5(PO4)3(OH)xFy having a length-to-breadth ratio of the crystals of at least ≧5.

The invention provides a method for synthesizing a nanometer hydroxylapatite bioactive material. The method comprises the following steps: firstly, synthesizing a nanometer hydroxylapatite water dispersion liquid by a liquid phase method; secondly, adding an orthosilicate compound, a catalyst, a water soluble organic solvent to the nanometer hydroxylapatite water dispersion liquid; stirring the mixed solution for 2 to 48 hours with the pH value of between 8 and 11 at a temperature of between 20 and 90 DEG C; and finally, washing a reaction product for at least three times to obtain nanometer hydroxylapatite coating silicon dioxide on the surface. The method can prepare the silicon dioxide coated nanometer hydroxylapatite bioactive material with a nuclear shell structure, wherein the grain size, the structure and main compositions are close to a bone nanometer apatite crystal of natural bone; therefore, the material has good bionic performance of the nanometer hydroxylapatite structure and high bioactivity of bioglass, and can be a perfect raw material for preparing a bone restoring material and a bone packing material used for medical treatment.

An antibacterial, antifouling paint for construction materials contains a coating resin composition and powdery metal-modified apatite. Part of metal atoms in the apatite crystal structure is provided by an optically catalytic metal. Preferably, the metal-modified apatite is a calcium hydroxyapatite which has part of its Ca atoms substituted by Ti.

A method for preserving food includes putting food in a container having an inner surface coated with a metal-modified apatite or in a container made of a material to which the metal-modified apatite is added, the metal-modified apatite having an apatite crystal structure including metal atoms partially comprising photocatalytic metal, and placing the container in a dark place at least temporarily.

The invention discloses a preparation and application method for a foamed ceramic soil remediation agent for clearing away heavy metal contamination of dry land. According to the method, biomass raw materials are used as a pore-forming agent, hydroxyapatite crystals [Ca10(PO4)6(OH)2] and amorphous calcium hydrophosphate (CaHPO4) in bone powder are used as raw materials for adsorbing heavy metals, and the preparation and application technology for the foamed ceramic soil remediation agent for clearing away heavy metal contamination of the dry land are provided. The preparation and application method are simple in process, low in cost and free of pollution, huge biomass resources are fully used, the heavy metals contained in soil are absorbed effectively, foamed ceramic is adopted, and the beneficial effects of the high porosity, the large specific surface area, the good absorption effect and the like of the foamed ceramic are adopted; and the adopted natural bone powder contains abundant Ca and P which are the human essential constant mineral elements, the heavy metals in soil are remedied, and the soil composition is improved.

The invention relates to yttrium aluminum silicate glass ceramic containing Y4.67(SiO4)3O apatite crystalline phase and a preparation method thereof. The preparation method comprises the following steps: S1, uniformly mixing the raw materials in proportion, heating to a molten state, and keeping the temperature to be constant, curing the molten liquid for molding, insulating to a preset time, andcooling to obtain yttrium aluminum silicate glass; S2, performing first heating on the yttrium aluminum silicate glass, insulating, nucleating, performing second heating, insulating, crystallizing, and cooling to obtain the yttrium aluminum silicate glass ceramic. According to the preparation method, the glass is subjected to crystallizing heat treatment after being molten from Y2O3, Al2O3 and SiO2 in the proportion, so that massive yttrium aluminum silicate glass ceramic having the main crystalline phase being Y4.67(SiO4)3O apatite can be prepared, the preparation process is simple, the operation is simple and convenient and the production cost is low, and massive Y4.67(SiO4)3O apatite crystal can be prepared in a short time.

The invention discloses preparation and differentiation methods of a micro-nano topological structure for promoting mesenchymal stem cell differentiation. A water-soluble fibroin solution is prepared, CaCl2 is added into the water-soluble fibroin solution for pre-mineralization, stirring is continuously carried out, and CaCl2 is dissolved; a Na2HPO4 solution is slowly dropped into the obtained solution through a constant flow pump device for mineralization; stirring continues to be carried out with a magnetic stirrer, so that apatite crystals are laminated on the water-soluble fibroin solution; the solution is centrifuged, supernate is poured away, sediment mineralizer is collected, deionized water is added, and the materials are mixed to be uniform; the steps are repeated, the obtained solution is dropwise added into a plastic plate or a mold, curing molding is carried out, and fibroin and apatite are compounded into a film with a micro-nano structure characteristic. The material is high in mechanical strength, micro-nano topological morphology is controllable, excellent differentiation inducibility to bone cells is shown, the material can be applied to repairing and replacing of bone defects, and the methods are used for biological material surface modification and modification and have wide application prospects.

The invention provides a polypeptide molecular derivative with a mineralizing function for biomedicine tissue engineering and application thereof, and belongs to the technical field of biomedical materials. The polypeptide molecular derivative has a molecular structure general formula of X-X-Cys-Cys-Cys-Cys-Y-Y-Z-W-NH2; wherein X is Asn or glucoylated asparagine; Y is Arg or Lys; Z is Glu or Asp;and W is phosphorylated serine or phosphorylated threonine. The polypeptide molecular derivative provided by the invention can induce the oriented growth of apatite crystals to form a biological material with a structure similar to an organism sclerous tissues microstructure; can be automatically assembled to form 3D (three-dimensional) nanometer hydrogel under the induction of calcium chloride, so as to be applied to a scaffold material for bone tissue engineering or to 3D in-situ cultivation of cells; can be compounded with collagenous fiber to induce the mineralization of the collagenous fiber, so as to be applied to study on bone tissue regeneration, as well as to induce the mineralizing regeneration and repair of cementum and dentin.

The invention relates to a method for preparing repairing material of antibacterial degradable active nanometer composite bionic tone tissue, comprising the following steps of: A, preparing a calcium-phosphorus solution with calcium chloride, sodium dihydrogen phosphate and the like, and mixing the calcium-phosphorus solution, the minocycline solution and the aqueous solution of gelation; B, carrying out reaction on the mixed solution in a silicone oil reactive bath; C, standing in motionless and ageing at the room temperature; D, centrifugalizing the aged substance to obtain the precipitate;freezing and drying the precipitate to obtain the repairing material for the bionic nanometer composite bionic bone tissue. The method adopts molecular bionic synthesis technology, simulates the process of bone mineralization and takes gelatine with excellent biocompatibility as an organic molecule template that regulates and controls growth of apatite (primary inorganic component of bone tissue)under physiologic condition to carry out biomimetic synthesis of repairing material for organic-inorganic composite bone tissue. Meanwhile, the antibacterial agent minocycline in the process of the growth of apatite crystal is loaded. Therefore, a novel antibacterial repairing material of nanometer composite bionic tone tissue is synthesized.

The invention belongs to the field of inorganic nonmetal materials, particularly belongs to a preparation method of an anti-bacterial tooth growing and repairing material, and relates to a growing and repairing anti-bacterial tooth material used in an alveolar cavity without a tooth or on the surface of an incomplete tooth. The anti-bacterial tooth growing and repairing material comprises the following main ingredients: apatite crystals containing silver, copper, calcium and phosphorus, titanium oxide and zinc oxide. Under the regulation and control effect of a binary polyelectrolyte compound consisting of water-soluble cationic polyelectrolyte and organic polyatomic acids, ingredients of the tooth growing and repairing material are synthesized with soluble calcium salt, soluble phosphate, copper sulfate and silver nitrate salt, a crystal natural growing method is used, and a dental matrix comprising the apatite crystals containing the silver, the copper, the calcium and the phosphorus, the titanium oxide and the zinc oxide are subjected to adsorption reaction fully. Crystalline grains of the anti-bacterial tooth growing and repairing material are in nanoscale, the copper and the silver can be fine and are uniformly distributed in the tooth growing and repairing material, diameters of metal particles are 30-80 nanometers, and the anti-bacterial tooth growing and repairing material can release anti-bacterial elements quickly and continuously.

The invention belongs to the field of inorganic nonmetallic materials, particularly discloses a hydrothermal synthesis method for preparation of a nano antibacterial tooth enamel layer and relates to attachment of the antibacterial tooth enamel layer in a general thickness of 0.2-0.8mm onto the surface of an artificial tooth, wherein the antibacterial tooth enamel layer is mainly made from apatite crystals containing silver, copper, calcium and phosphate. Under the control of a dual-polyelectrolyte compound consisting of water-soluble cation polyelectrolyte and organic polyatomic acid, the artificial tooth is put into soluble calcium salts, soluble phosphates, copper sulfate and silver nitrate salts to realize synthesis to finally cover the artificial tooth with the antibacterial tooth enamel layer in the general thickness of 0.2-0.8mm. The antibacterial tooth enamel layer is mainly made from apatite crystals containing silver, copper, calcium and phosphate, and crystal grains of the enamel layer are nanoscale crystal grains, so that copper and silver metallic particles smaller in size can be distributed in the enamel more uniformly; the metallic particles are 30-80nm in diameter, and antibacterial elements can be released quickly and constantly.

Disclosed is an Mg-based structured member, wherein the surface of a base is covered with a film that is mainly composed of apatite crystals. The film and the base can be integrated via a magnesium hydroxide layer. The surface of the film can be coated with a resin coating material, and the film can have a thickness of 1-5 [mu]m. The Mg-based structured member places only a little burden on the environment during the production process thereof.

The invention discloses a preparation method of microbubble energy-saving soft porcelain, belonging to the technical field of building and decoration material preparation. The energy-saving effect ofthe soft porcelain is embodied in two aspects. The soft porcelain is mainly prepared from blast furnace slag and fly ash, that is, the soft porcelain meets environment protection and energy conservation requirements in material utilization. During press forming process, silica sol infiltrates into liquid paraffin to form a silica core structure, wherein the liquid paraffin is used as a phase-change temperature-regulating material. In the invention, a liquid phase during sintering mainly comes from the silica sol, and amorphous silica in the silica sol is first subjected to gel dehydration andparticle aggregation during heating process, nitrogen in ammonia gas is fixed into fermentation filter residue through the slight rotting effect of microorganisms in peels, the nitrogen-containing fermentation filter residue and soft porcelain slurry are mixed and then subjected to hot press sintering to form a hexagonal boron nitride crystal, thereby improving the heat preservation and energy conservation effect; bone powder added contains hydroxyapatite crystals and amorphous hydrogen phosphate, so that the soft porcelain looks more textured, and has broad application prospects in building decoration materials.

The present invention discloses a developing agent made of apatite and the positron emission tomography (PET) of developing agent, relating to the field of biomedical material and medical imaging. The present invention is characterized in that the apatite is added with positron emitting nuclide during the compound; and the positron emitting nuclide is to displace partial OH- in the apatite to be included in the structure of apatite crystalloid; thus, the apatite developing agent marked with positron is obtained. The animal experiment shows that: when the apatite developing agent is injected in the rabbit through the vein at the ear edge, the present invention not only can give a real-time image of the entire rabbit with the PET, but also can measure the blood thickness and the emission thickness of every organ with dynamic PET; the dynamics parameter of drug metabolism of apatite and the drug metabolism speed can also be calculated. The present invention not only can prepare a new developing agent of apatite PET imaging for the first time, but also provides the probability for the apatite in the research of distribution in the organ and metabolism dynamics.