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Preparation method of nano apatite crystal composite tissue engineering support material

A scaffold material and composite tissue technology, used in prostheses, drug devices, medical science and other directions, can solve the problems of weak interface bonding, composite interface damage, loss of mechanical strength of composite materials, etc.

Inactive Publication Date: 2004-05-05
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the weak interfacial bonding force between HA powder and polymer used as filler in the HA and polymer composite materials studied in the past, the composite interface is first destroyed during application, which leads to excessive loss of mechanical strength of the composite material. quick

Method used

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  • Preparation method of nano apatite crystal composite tissue engineering support material
  • Preparation method of nano apatite crystal composite tissue engineering support material

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0023] Preparation of nanoapatite crystals / polyamide 66 composites:

[0024] 164 grams of analytically pure calcium nitrate and 98.4 grams of sodium phosphate were added to a 3000ml three-necked bottle with water separator, stirring device and condensing device, and then 1500ml of N, N-dimethylacetamide (DMAC) was added. The temperature was gradually increased to 140° C., 55 g of polyamide 66 (molecular weight 23,000, supplied by Asahi Chemical Industry Co.) was added, and kept at 140° C. for 4 hours. Until the polyamide 66 is completely dissolved, cool to room temperature, slowly drop the mixture into a stainless steel pot filled with deionized water under constant stirring, heat to gradually increase the temperature of the mixture to 70°C, keep it warm for 2 hours, and then Cool to room temperature and age for 24 hours. Wash the product 3 times with deionized water, pour it into a beaker, raise the temperature to 95°C-100°C, and keep it warm for 3 hours; carry out hydrother...

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Abstract

A composite tissue-engineered porous scaffold material is prepared from the nano-class hydroxy phosphorite particles, medical polyamide and foaming agent through proportionally mixing, heating to fuse it, injection moulding under 30-50 MPa to form porous scaffold, and removing the surficial layer to open the pores. Its advantage is high mechanical performance.

Description

technical field [0001] The invention relates to a preparation method of a nano-apatite crystal composite tissue engineering support material, specifically a preparation method of a porous tissue engineering support material in the form of a nano-hydroxyapatite / medical polyamide compound. Background technique [0002] One of the key technologies of tissue engineering is the research and preparation of scaffold materials. [0003] Natural bone is an inorganic / organic composite material composed of nano-apatite and polymer collagen fibers, which has good mechanical properties. Based on the concept of bionics, people hope to prepare a bioactive material with good mechanical strength and toughness, and an elastic modulus close to natural bone. As a tissue engineering scaffold material for extracellular matrix, it must have good mechanical strength, and it is difficult for a single material to meet the requirements of bone tissue engineering cell scaffold materials. For example,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/56A61L31/12A61M31/00B29C45/00C08L77/00
Inventor 李玉宝魏杰杨爱萍
Owner SICHUAN UNIV
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