Preparation method of nano apatite crystal composite tissue engineering support material

A scaffold material and composite tissue technology, which is applied in prostheses, pharmaceutical devices, medical science, etc., can solve problems such as weak interface binding force, composite interface damage, and loss of mechanical strength of composite materials.

A scaffold material and composite tissue technology, which is applied in prostheses, pharmaceutical devices, medical science, etc., can solve problems such as weak interface binding force, composite interface damage, and loss of mechanical strength of composite materials.

CN1225290CInactive Publication Date: 2005-11-02SICHUAN UNIV
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  • Preparation method of nano apatite crystal composite tissue engineering support material
  • Preparation method of nano apatite crystal composite tissue engineering support material

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Embodiment Construction

[0023] Preparation of nanoapatite crystals / polyamide 66 composites:

[0024] 164 grams of analytically pure calcium nitrate and 98.4 grams of sodium phosphate were added to a 3000ml three-necked bottle with water separator, stirring device and condensing device, and then 1500ml of N, N-dimethylacetamide (DMAC) was added. The temperature was gradually increased to 140° C., 55 g of polyamide 66 (molecular weight 23,000, supplied by Asahi Chemical Industry Co.) was added, and kept at 140° C. for 4 hours. Until the polyamide 66 is completely dissolved, cool to room temperature, slowly drop the mixture into a stainless steel pot filled with deionized water under constant stirring, heat to gradually increase the temperature of the mixture to 70°C, keep it warm for 2 hours, and then Cool to room temperature and age for 24 hours. Wash the product 3 times with deionized water, pour it into a beaker, raise the temperature to 95°C-100°C, and keep it warm for 3 hours; carry out hydrother...

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Abstract

A composite tissue-engineered porous scaffold material is prepared from the nano-class hydroxy phosphorite particles, medical polyamide and foaming agent through proportionally mixing, heating to fuse it, injection moulding under 30-50 MPa to form porous scaffold, and removing the surficial layer to open the pores. Its advantage is high mechanical performance.

Description

technical field [0001] The invention relates to a preparation method of a nano-apatite crystal composite tissue engineering support material, specifically a preparation method of a porous tissue engineering support material in the form of a nano-hydroxyapatite / medical polyamide compound. Background technique [0002] One of the key technologies of tissue engineering is the research and preparation of scaffold materials. [0003] Natural bone is an inorganic / organic composite material composed of nano-apatite and polymer collagen fibers, which has good mechanical properties. Based on the concept of bionics, people hope to prepare a bioactive material with good mechanical strength and toughness, and an elastic modulus close to natural bone. As a tissue engineering scaffold material for extracellular matrix, it must have good mechanical strength, and it is difficult for a single material to meet the requirements of bone tissue engineering cell scaffold materials. For example,...

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Application Information

Patent Timeline
02 Nov 2005
Publication
CN1225290C
IPC
A61L27/44; A61L27/56; A61L31/12; A61M31/00; B29C45/00; C08L77/00
Inventors
李玉宝; 魏杰