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Prepn process of nano level osteoid apatite crystal

A bone-like apatite, nano-scale technology, applied in chemical instruments and methods, prostheses, phosphorus compounds, etc., can solve the problems of strong irritating odor of ammonia water, harmful to human body, and large environmental pollution.

Inactive Publication Date: 2003-03-19
SICHUAN UNIV
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Problems solved by technology

Ammonia water has a strong pungent smell, is harmful to the human body, and causes great environmental pollution.
In addition, there is also a method of preparing nano-scale apatite crystals through the neutralization reaction of calcium hydroxide and phosphoric acid. Although ammonia water is not required, it is difficult to prepare satisfactory nano-scale bone due to the poor solubility of calcium hydroxide. Apatite crystals

Method used

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  • Prepn process of nano level osteoid apatite crystal
  • Prepn process of nano level osteoid apatite crystal
  • Prepn process of nano level osteoid apatite crystal

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Embodiment Construction

[0015] Get 12 grams of sodium phosphate (analytically pure) and dissolve it in 1000 milliliters of deionized water to form a solution, and then dissolve 20 grams of calcium nitrate (analytical pure) in 30 grams of acetamide while heating and keeping it at 70 ° C and constantly stirring. (Analytical pure) The resulting solution was slowly added dropwise to the sodium phosphate solution. After dropping, the mixture was stirred and reacted for 2 hours while maintaining the same temperature, and aged for 24 hours at room temperature. After centrifugation, the supernatant was discarded, and then washed with water for 3 times to obtain a slurry of nano-scale bone-like apatite crystal deposits.

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Abstract

Nano level osteolith crystal is prepared through reaction of calcium salt and alkali metal phosphate dissolved in acetamide or formamide medium containing water in 0-50 vol%. The material calcium salt and alkali metal phosphate are in such amount that the molar ratio between calcium and phosphor is 1.50-1.67, during the reaction, one kind of solution is dropped into the other solution, and after finishing the reaction and through aging for 24 hr, the deposit is washed with deionized water to obtain the slurry of the osteolith crystal. The prepared nano level osteolith crystal is similar to natural osteolith crystal and has excellent biological activity and thus may be used in preparing inorganic / organic nano composite bone repairing and replacing material.

Description

technical field [0001] The invention relates to a method for preparing nanoscale bone-like apatite crystals under normal pressure conditions. Background technique [0002] Hydroxyapatite (HA) has good biocompatibility and osteoconductivity, can form a biochemical bond with natural bone, and is widely used as a repair material for human bone tissue. Existing research reports that human natural bone is mainly composed of organic collagen and inorganic mineral components, wherein the inorganic mineral components are mainly nano-scale apatite crystals, which account for about 65% of the bone, and also contain a small amount of carbonate ions, Sodium ions and hydrogen phosphate ions and other components. These bioapatite crystals are in the shape of needles of approximately 20 nm x 40 nm. In order to simulate natural bone apatite crystals, a method for synthesizing nano-scale hydroxyapatite needle crystals under normal pressure was reported in "High Technology Communication" 20...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/00C01B25/32
Inventor 李玉宝魏杰左奕
Owner SICHUAN UNIV
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