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Method for synthesizing nano hydroxylapatite material with biological activity

A nano-hydroxyapatite, bioactive technology, used in medical science, prosthesis and other directions, can solve the problems of agglomeration, crystal thickening and increase, reducing biological activity and interface reactivity, etc. Processed, stimulating and inducing effects

Inactive Publication Date: 2009-05-20
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But from the perspective of the whole preparation process, whether it is wet preparation or dry preparation, in order to form a homogeneous doping of silicon and apatite, the purpose of high-temperature calcination is to improve the reactivity, but the prepared hydroxyphosphorus The agglomeration of limestone powder is serious during the drying and calcination process, and the crystals become thicker and larger, which is far from the weak crystal nano-bone apatite structure in human bones, which reduces biological activity and interface reactivity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Step 1, preparation of nano-hydroxyapatite aqueous dispersion

[0026] (1), prepare nano-hydroxyapatite with the liquid phase method in the prior art: 0.5mol analysis pure calcium hydroxide (content is 96%) adds deionized water and is made into the calcium hydroxide that concentration is 0.5mol / liter Dispersion liquid, after stirring 30 minutes with the rotating speed of 1000 rpm; 0.3mol analytically pure phosphoric acid (content is 85%) adds deionized water to 1.5 liters, is made into the phosphoric acid solution that concentration is 0.2Mol / liter; Then Phosphoric acid solution was added dropwise to the calcium hydroxide dispersion, then stirred for 2 hours, and aged at room temperature for 24 hours to obtain nano-hydroxyapatite;

[0027] (2), the nano-hydroxyapatite obtained in the above (1) was centrifugally washed 3 times with deionized water, and then added ionized water to be mixed with 1033g of an aqueous dispersion with a mass content of hydroxyapatite of 7.5%; ...

Embodiment 2

[0031] Step 1, preparation of nano-hydroxyapatite aqueous dispersion

[0032] (1), prepare nano-hydroxyapatite with the liquid phase method in the prior art: 0.3mol analytical pure sodium phosphate is made into the aqueous solution of 0.1mol / liter, the sodium phosphate solution temperature is adjusted to 70 ℃, simultaneously 0.5mol Calcium nitrate is made into a 0.2mol / liter aqueous solution, and then the above-mentioned calcium nitrate is added dropwise to the prepared sodium phosphate solution in a stirred state. The time for the addition is 2 hours. Adjust the pH to 10, continue to stir for one hour, age at room temperature for 24 hours, centrifuge to remove the supernatant, and obtain nano-hydroxyapatite;

[0033] (2), the above-mentioned (1) gained nano-hydroxyapatite was centrifuged and washed 3 times with deionized water, and then added ionized water to be mixed with 201 g of an aqueous dispersion with a hydroxyapatite content of 25%;

[0034] Step 2, preparation of na...

Embodiment 3

[0037] Step 1, preparation of nano-hydroxyapatite aqueous dispersion

[0038] (1), prepare nano-hydroxyapatite with the liquid phase method in the prior art: the analytically pure calcium nitrate is configured into the solution of 0.1mol / liter, and the triethyl phosphate of 0.06mol analytically pure is dissolved in 150 milliliters of Transfer the absolute ethanol into the flask, quickly add 1 liter of the prepared calcium nitrate solution into the triethyl phosphate ethanol solution under the condition of stirring at a speed of 1000 rpm, and then adjust the pH of the above solution to 11 with ammonia water , and placed in a water bath at a temperature of 50°C, heated and stirred for 4 hours, aged at room temperature for 24 hours after the reaction was completed, and centrifuged to remove the supernatant to obtain nano-hydroxyapatite;

[0039] (2) The nano-hydroxyapatite obtained in the above (1) was centrifugally washed 3 times with deionized water, and then added ionized wate...

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Abstract

The invention provides a method for synthesizing a nanometer hydroxylapatite bioactive material. The method comprises the following steps: firstly, synthesizing a nanometer hydroxylapatite water dispersion liquid by a liquid phase method; secondly, adding an orthosilicate compound, a catalyst, a water soluble organic solvent to the nanometer hydroxylapatite water dispersion liquid; stirring the mixed solution for 2 to 48 hours with the pH value of between 8 and 11 at a temperature of between 20 and 90 DEG C; and finally, washing a reaction product for at least three times to obtain nanometer hydroxylapatite coating silicon dioxide on the surface. The method can prepare the silicon dioxide coated nanometer hydroxylapatite bioactive material with a nuclear shell structure, wherein the grain size, the structure and main compositions are close to a bone nanometer apatite crystal of natural bone; therefore, the material has good bionic performance of the nanometer hydroxylapatite structure and high bioactivity of bioglass, and can be a perfect raw material for preparing a bone restoring material and a bone packing material used for medical treatment.

Description

technical field [0001] The invention relates to a method for synthesizing a nano-hydroxyapatite bioactive material. The obtained nano-hydroxyapatite bioactive material can be used as a new type of inorganic biomaterial for repairing and filling bone tissue defects in surgical operations. technical background [0002] The core / shell composite structure nanoparticle is a nanoscale ordered assembly structure formed by one nanomaterial covering another nanomaterial through chemical bonds or other interactions. It is a higher-level composite nanostructures. In the past ten years, researchers have focused on core-shell materials with certain functions, magnetic properties, photoelectric conversion, and photocatalysis. The surface of nanoparticles has been coated with polymers, organic substances, inorganic compounds, simple elements, biological macromolecules and other shell materials, which has improved the surface properties of the particles, enhanced the stability of the parti...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/02
Inventor 宋志国邱建备尹兆益
Owner KUNMING UNIV OF SCI & TECH
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