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Apatite developer and its positron emitting tomography imaging

A technology of apatite and developer, applied in the field of biomedical materials, can solve problems such as difficulty in obtaining three-dimensional dynamic distribution and metabolic images, and difficult technical operations

Inactive Publication Date: 2008-02-20
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, markers related to common apatite at home and abroad mainly include 45 Ca, 99m T c - Bisphosphonic acid complexes and rhenium markers, etc. These methods can only reflect the distribution and metabolism of the local region of interest. In most cases, the model animals need to be killed to obtain the desired results. Obtain a complete three-dimensional dynamic distribution and metabolism image of the whole body, and there is no report on its application in real-time imaging of apatite in vivo and apatite pharmacokinetics

Method used

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  • Apatite developer and its positron emitting tomography imaging

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Prepare the same volume of 0.01 mol / L calcium hydroxide aqueous solution and 0.006 mol / L phosphoric acid aqueous solution, adjust the calcium hydroxide aqueous solution to pH 10 with ammonia water, and then slowly add the phosphoric acid aqueous solution to the calcium hydroxide aqueous solution through a constant flow pump During the dropwise addition, the oil bath was maintained at 90°C. After the dropwise addition, the positron nuclides generated by the cyclotron 18 F (or 76 Br, 75 Br, 124 1) Pour into the mixed solution, continue to maintain the stirring state, and keep the temperature at 60°C. After 2.5 hours, the suspension containing apatite developer was taken out, washed three times with deionized water, and the measured specific activity was 0.014mCi / mg.

[0035] One healthy New Zealand white rabbit was taken, and after being fully anesthetized, apatite contrast agent injection with a radiation dose of 1.02mCi was injected through the ear vein. Immediately...

Embodiment 2

[0038] Prepare the same volume of 1 mol / liter calcium acetate monohydrate aqueous solution and 0.6 mol / liter ammonium dihydrogen phosphate aqueous solution, adjust the calcium acetate monohydrate to pH 7.0 with ammonia water, and prepare the calcium and fluorine molar ratio of 10:0.01 in diphosphate Add ammonium fluoride into the ammonium hydrogen solution, and then slowly drop the ammonium dihydrogen phosphate solution dissolved in ammonium fluoride into the calcium acetate monohydrate solution through a constant flow pump, and keep the oil bath at 80°C. Accelerator-produced positron nuclides 18 Pour F into the mixture, keep stirring and keep the temperature at 60°C. After 3 hours, the suspension containing apatite developer was taken out, washed 3 times with deionized water, and the measured specific activity was 0.134mCi / mg.

[0039] Two healthy New Zealand white rabbits were taken, and after being fully anesthetized, 1.01 mCi of apatite buffered saline dispersion was inje...

Embodiment 3

[0041] Prepare the same volume of 0.5 mol / liter calcium chloride aqueous solution and 0.3 mol / liter diammonium hydrogen phosphate aqueous solution, adjust the calcium chloride aqueous solution to a pH value of 8.5 with ammonia water, and prepare the calcium chloride aqueous solution according to the calcium-zinc molar ratio of 10:0.5 in calcium chloride Zinc chloride is added to the aqueous solution, and ammonium fluoride is added to the diammonium hydrogen phosphate aqueous solution according to the molar ratio of calcium to fluorine of 10:1, and then the diammonium hydrogen phosphate aqueous solution is slowly added dropwise to the calcium chloride aqueous solution through a constant flow pump to maintain oil bath at 60°C, the positron nuclides produced by the cyclotron 18 Pour F into the mixture, keep stirring and keep the temperature at 60°C. After 3 hours, the suspension containing apatite developer was taken out, washed 5 times with deionized water, and the measured spec...

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Abstract

The present invention discloses a developing agent made of apatite and the positron emission tomography (PET) of developing agent, relating to the field of biomedical material and medical imaging. The present invention is characterized in that the apatite is added with positron emitting nuclide during the compound; and the positron emitting nuclide is to displace partial OH- in the apatite to be included in the structure of apatite crystalloid; thus, the apatite developing agent marked with positron is obtained. The animal experiment shows that: when the apatite developing agent is injected in the rabbit through the vein at the ear edge, the present invention not only can give a real-time image of the entire rabbit with the PET, but also can measure the blood thickness and the emission thickness of every organ with dynamic PET; the dynamics parameter of drug metabolism of apatite and the drug metabolism speed can also be calculated. The present invention not only can prepare a new developing agent of apatite PET imaging for the first time, but also provides the probability for the apatite in the research of distribution in the organ and metabolism dynamics.

Description

technical field [0001] The invention relates to the fields of biomedical materials and medical imaging, and specifically includes a preparation method of an apatite contrast agent and its positron emission tomography (PET) imaging. Background technique [0002] The apatite imaging agent labeled with positron nuclide is a special imaging agent for apatite positron emission tomography (PET). For PET medical imaging technology, the research and development of imaging agent itself is the most popular and cutting-edge research topic in the field of molecular nuclear medicine and molecular imaging, because the prerequisite for PET imaging is the preparation of various specific PET drugs (also known as positron imaging agents or positron drugs). [Tang Ganghua, Preparation of positron radionuclides and their application in the field of pharmacy. Chinese Journal of Medicinal Chemistry, 2003(13)1: p59] [0003] Apatite (Apatite) is the main inorganic component of human and animal b...

Claims

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Application Information

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IPC IPC(8): A61K51/02A61K101/02
CPCA61K51/02
Inventor 张胜民周为
Owner HUAZHONG UNIV OF SCI & TECH
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