Preparation method of nano-hydroxy apatitel poly vinyl alcohol composite hydrogel

A nano-hydroxyapatite and composite hydrogel technology, which is applied in the field of biomedical composite materials, can solve the problems of fragmentation, high brittleness, and difficulty in meeting artificial corneal stents.

Inactive Publication Date: 2005-08-10
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the hydroxyapatite used in this patented technology has low strength and high brittleness, and it will be broken when processed to a thickness of 2 mm. On the one hand, it is difficult to meet the requirement that the thickness of the artificial corneal stent should be controlled below 1 mm.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The first step: preparing nano-hydroxyapatite crystals: the weight percentage of water is 1%: 99% slurry;

[0026] The second step: refining and purifying the solid polyvinyl alcohol;

[0027] The third step: adding the polyvinyl alcohol obtained in the second step to the slurry obtained in the first step, the weight percentage of polyvinyl alcohol is 25%, and fully stirring at 90°C;

[0028] The fourth step: Pour the result of the third step into the mold, and freeze-melt it into shape. That is, nano-hydroxyapatite / polyvinyl alcohol composite hydrogel is obtained.

Embodiment 2

[0030] The first step: preparing nano-hydroxyapatite crystals: a slurry with a weight percentage of water of 10%:90%;

[0031] The second step: refining and purifying the polyvinyl alcohol;

[0032] The third step: adding the polyvinyl alcohol obtained in the second step to the slurry obtained in the first step, so that the weight percentage of the polyvinyl alcohol is 20%, and fully stirring at 100°C;

[0033] The fourth step: Pour the result of the third step into the mold, and freeze-melt it into shape. That is, nano-hydroxyapatite / polyvinyl alcohol composite hydrogel is obtained.

Embodiment 3

[0035] The first step: preparing nano-hydroxyapatite crystals: a slurry whose weight percentage of water is 20%: 80%;

[0036] The second step: refining and purifying the polyvinyl alcohol;

[0037] The third step: adding the polyvinyl alcohol obtained in the second step to the slurry obtained in the first step, so that the weight percentage of the polyvinyl alcohol is 10%, and fully stirring at 120°C;

[0038] Step 4: Pour the result obtained in Step 3 into a mold, and freeze-melt to obtain a nano-hydroxyapatite / polyvinyl alcohol composite hydrogel.

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PUM

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Abstract

A process for preparing the composite hydrogel of nano-hydroxy apatite and polyvinyl alcohol includes such steps as preparing nano-class hydroxyapatite crystal slurry, preparing purified polyvinyl alcohol solution, mixing them together, and freeze-thaw shaping.

Description

technical field [0001] The invention relates to the field of biomedical composite materials, in particular to a method for preparing a biomedical composite material for allogeneic articular cartilage transplantation and replacement or allogeneic corneal transplantation and replacement. Background technique [0002] Injuries and lesions of articular cartilage are common diseases in clinical orthopedics. Due to the limited self-repair ability of articular cartilage in the body, it is difficult to heal itself once damaged or lesions occur. Clinical treatment mainly involves allogeneic cartilage transplantation and joint prosthesis replacement. However, the source of donors for cartilage transplantation is limited. Currently, the commonly used artificial joint material is ultra-high molecular weight polyethylene combined with metal. Since it is difficult to form a liquid film for lubrication, the ultra-high molecular weight polyethylene components produce excessive wear debris. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16C08K3/32C08L29/04
Inventor 李玉宝许凤兰
Owner SICHUAN UNIV
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