Bacteria cellulose composite material as well as preparation method and use thereof

Abstract

The invention belongs to the field of biologic materials, and discloses to a bacteria cellulose composite material, as well as a preparation method and an application thereof. Polypeptide with a phosphate radical is grafted on the fiber surface of bacteria cellulose with a nanometer fiber meshwork. A phosphate radical negative ion area can attract calcium positive ions to subside in the bacteria cellulose composite material under the body fluid environment; a hydroxyapatite crystal is induced to be directly mineralized on the surface of the nanometer fiber; and a nanometer gap structure formed by the nanometer fiber network can be taken as a support frame to facilitate the adhesion, the multiplication and the differentiation of osteocytes , therefore, the bacteria cellulose composite material can be used as defective human bone filling and rehabilitating materials.

Description

technical field

[0001] The invention relates to the field of biomaterials, more specifically, the invention relates to a bacterial cellulose composite material capable of promoting bone repair in a body fluid environment and a preparation method thereof. Background technique

[0002] Bacterial cellulose (BC), a natural polymer secreted by bacteria, has unique physical and chemical properties such as high crystallinity, high water holding capacity, ultrafine nanofiber network, high tensile strength and elastic modulus, and has been studied It is used in artificial blood vessels, artificial skin, treatment of skin injuries, and tissue engineering scaffolds. As a bone tissue engineering scaffold, BC is simple and cheap, has high wet strength and can be formed in situ, so it has become an international medical biomaterial in recent years. research hotspots. Tufts University [A Svensson, E Nicklasson, T Harrah, B Panilaitis, D L Kaplan, M Brittberg, P Gatenholm. Bacterial cellul...

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