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Organic-inorganic compound bone restoration bioactive material

An inorganic composite and biologically active technology, applied in medical science, prostheses, etc., can solve the problems of bone-like apatite structure scale and crystallinity, so as to improve reactivity and integration rate, mix uniformly, and avoid direct The effect of reunion

Inactive Publication Date: 2009-04-08
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Therefore, composite scaffolds made by combining nano-apatite and polymer materials are currently used as bone tissue engineering materials. Composite preparation of polymer-nano hydroxyapatite composites, or the use of silicon doping to prepare highly biologically active hydroxyapatite as an inorganic component, cannot take into account the structural scale and bone-like apatite structure of nano-hydroxyapatite. Crystallinity, and physiological reactivity, therefore, it is absolutely necessary to improve the existing technology to overcome the above-mentioned deficiencies

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Step 1, preparation of nano-hydroxyapatite aqueous dispersion

[0032](1), prepare nano-hydroxyapatite with the liquid phase method in the prior art: it is the solution that concentration is 0.1mol / liter to be formulated with analytically pure calcium nitrate and diammonium hydrogen phosphate respectively, under stirring condition, 6 liters Diammonium hydrogen phosphate solution was added dropwise to 10 liters of calcium nitrate solution. During the dropwise addition process, the pH of the reaction medium was adjusted to 10.5 with concentrated ammonia water. The dropwise addition time was 1 hour, then continued to stir for 2 hours, and then aged at room temperature. After 24 hours, the supernatant was removed by centrifugation to obtain nano-hydroxyapatite;

[0033] (2), the above-mentioned (1) gained nano-hydroxyapatite was centrifuged and washed 3 times with deionized water, and then added ionized water to be mixed with 4016g of an aqueous dispersion with a hydroxyapa...

Embodiment 2

[0044] Step 1, preparation of nano-hydroxyapatite aqueous dispersion

[0045] (1), prepare nano-hydroxyapatite with the liquid phase method in the prior art: 0.5mol analysis pure calcium hydroxide (content is 96%) adds deionized water and is made into the calcium hydroxide that concentration is 0.5mol / liter Dispersion liquid, after stirring for 30 minutes with the rotating speed of 1000 rpm, add deionized water to 1.5 liters with 0.3mol analytically pure phosphoric acid (content is 85%), be made into the phosphoric acid solution that concentration is 0.2Mol / liter; Then Phosphoric acid solution was added dropwise to the calcium hydroxide dispersion, then stirred for 2 hours, and aged at room temperature for 24 hours to obtain nano-hydroxyapatite;

[0046] (2), the nano-hydroxyapatite obtained in the above (1) was centrifugally washed 3 times with deionized water, and then added ionized water to be mixed with 1033g of an aqueous dispersion with a mass content of hydroxyapatite o...

Embodiment 3

[0057] Step 1, preparation of nano-hydroxyapatite aqueous dispersion:

[0058] (1), prepare nano-hydroxyapatite with the liquid phase method in the prior art: 0.3mol analytical pure sodium phosphate is made into 1 liter of aqueous solution, the temperature of sodium phosphate solution is adjusted to 70 ℃, simultaneously 0.5mol calcium nitrate is formulated 1 liter of aqueous solution, and then add the above-mentioned calcium nitrate dropwise to the prepared sodium phosphate solution in a stirred state. The dropwise addition time is 2 hours. After the dropwise addition, adjust the pH of the reaction product to 10 with dilute sodium hydroxide solution, and continue Stir for one hour, age at room temperature for 24 hours, centrifuge to remove the supernatant to obtain nano-hydroxyapatite;

[0059] (2) Using deionized water to centrifugally wash the nano-hydroxyapatite obtained in the above (1) for 3 times, and then add ionized water to prepare 201 g of an aqueous dispersion with ...

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Abstract

The invention provides an organic-inorganic composite bone repair bioactive material, which is synthesized by using nanometer hydroxyapatite of which the surface is coated with silicon dioxide as an inorganic component, using a biodegradable water-soluble polymer material as an organic component, and according to the mass ratio of the organic component to the inorganic component being equal to between 10 to 1 and 1 to 9. The composite bone repair bioactive material using the nanometer hydroxyapatite of which the surface layer is coated with the silicon dioxide as the inorganic component has better biological reactivity compared with the composite bone repair material using a single nanometer hydroxyapatite as the inorganic component, and overcomes the problems that the prior composite bone repair material using a silicon-doped modified hydroxyapatite as the inorganic component has low biological activity and poor interface reactivity cased by the defects of serious agglomeration and the like due to the excessively large crystal of the hydroxyapatite, thereby having the characteristic of better biological reactivity.

Description

technical field [0001] The invention relates to an organic-inorganic composite biomaterial, in particular to a novel organic-inorganic composite biomaterial used for repairing and filling bone tissue defects in surgical operations. Background technique [0002] Tissue engineering provides new methods and ideas for the repair of bone defects. Three-dimensional scaffold materials, that is, extracellular matrix substitutes, are one of the keys to bone tissue engineering research. Bone scaffold materials can not only induce the transformation of surrounding tissues into bone, but also serve as a carrier for transplanted bone cells. They should have good biocompatibility, osteoconductivity, osteoinductivity, and good mechanical properties. However, the existing single material is difficult to meet the requirements of bone tissue engineering for scaffold materials. Based on the concept of bionics, natural bone is an inorganic-organic composite material composed of nano-apatite and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/22A61L27/20A61L27/18A61L27/12A61L27/02
Inventor 宋志国邱建备尹兆益
Owner KUNMING UNIV OF SCI & TECH
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