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Method for prenaring spherical hydroxy-apatite nano crystal

A technology of hydroxyapatite and nanocrystals, which can be used in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., and can solve the problems that the preparation method of spherical HAp crystals has not been reported.

Inactive Publication Date: 2006-08-23
FUJIAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Various methods for the preparation of columnar or needle-shaped HAp crystals have been reported in the literature, but there is no report on the preparation of spherical HAp crystals in aqueous solution.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Weigh 1.181g (0.005mol) Ca(NO 3 ) 2 4H 2 O powder was evenly spread on the bottom of a 100mL beaker, and another 0.609g (0.003mol) (NH 4 ) 3 PO 4 ·3H 2 The O powder was spread flat on the bottom of a 50mL beaker. Put the 50mL beaker into the 100mL beaker, then slowly add 100mL of an aqueous solution with ammonia water preset to pH = 10.5 and a mass fraction of 0.02% PVP along the inner walls of the two beakers. Placed for 7 days, the obtained precipitate was washed with secondary water first, then washed with absolute ethanol, suction filtered, dried at 100°C for 12 hours, and weighed 0.455g of the product. Transmission electron microscopy showed that HAp crystals were spherical, with a diameter of about 15- 25nm.

Embodiment 2

[0018] Weigh 1.181g (0.005mol) Ca(NO 3 ) 2 4H 2 O powder was spread on the bottom of a 500mL beaker, and another 0.609g (0.003mol) (NH 4 ) 3 PO 4 ·3H 2 The O powder was spread flat on the bottom of a 250mL beaker. Put the 250mL beaker into the 500mL beaker, then slowly add 500mL of aqueous solution with ammonia water preset to pH = 10.5 and 0.5% PVP along the inner wall of the two beakers, seal it with plastic wrap, and let it stand at an ambient temperature of 25°C. Set aside for 7 days, the resulting precipitate was first washed with secondary water, then washed with absolute ethanol, suction filtered, dried at 100°C for 12 hours, and weighed 0.452g. The transmission electron microscope of the product shows that the HAp crystal is spherical, with a diameter of about 30-40nm.

Embodiment 3

[0020] Weigh 4.724g (0.02mol) Ca(NO 3 ) 2 4H 2 O powder was evenly spread on the bottom of a 100mL beaker, and another 2.436g (0.012mol) (NH 4 ) 3 PO 4 ·3H 2 The O powder was spread flat on the bottom of a 50mL beaker. Put the 50mL beaker into the 100mL beaker, then slowly add 100mL of aqueous solution with ammonia water preset to pH=10.5 and 0.5% PVP along the inner walls of the two beakers, seal it with plastic wrap, and let it stand at an ambient temperature of 25°C. Set aside for 7 days, the resulting precipitate was first washed with secondary water, then washed with absolute ethanol, filtered with suction, dried at 100°C for 12 hours, and weighed 1.85g. The transmission electron microscope of the product shows that the HAp crystal is spherical, with a diameter of about 40-50nm.

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PUM

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Abstract

The process of preparing spherical nanometer hydroxyapatite crystal in water solution features that spherical nanometer hydroxyapatite crystal is synthesized with water soluble polymer PVP as template and through a biomineralization process. The process includes: spreading Ca(NO3)2íñ4H2O powder in the bottom of container A, preading (NH4)3PO4íñ3H2O powder in the weight ratio to Ca(NO3)2íñ4H2O of 1 to 1.67 in the bottom of container B, setting the container B inside the container B, slowly adding PVP aqua of pH 10.5 and concentration 0.02-2 wt% along in inner walls of the two containers to Ca(NO3)2íñ4H2O concentration of 0.01-0.20 mol / L and (NH4)3PO4íñ3H2O concentration of 0.006-0.12 mol / L and the solution overflow through the edge of the container B, stilling at 25 deg.c for 7 days to obtain precipitate, washing the precipitate, sucking filtering and drying to obtain the spherical nanometer hydroxyapatite crystal product. Altering the PVP concentration can regulate the crystal size in 15-150 nm.

Description

technical field [0001] The invention relates to a method for preparing spherical hydroxyapatite nanocrystals in aqueous solution. technical background [0002] Hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 , Hydroxyapatite, HAp for short] is the main inorganic component of human bones and teeth. The synthetic HAp has good biocompatibility, bioactivity and osteoconductivity, and is an excellent hard tissue replacement material. In recent years, with the rapid development of nano-HAp material research, people have a further understanding of the characteristics of HAp, such as nano-HAp can inhibit a variety of cancer cells, but has no effect on normal cells, or can be used as a drug for HIV virus growth Carrier, or liquid chromatography separation agent used to separate various biomolecules, etc. The synthesis methods of nano-HAp mainly include chemical precipitation method, hydrothermal reaction method, sol-gel method self-combustion method and microemulsion method, etc. Usually...

Claims

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Application Information

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IPC IPC(8): C01B25/32
Inventor 刘榕芳肖秀峰邱超凡
Owner FUJIAN NORMAL UNIV
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