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Sr and Mg doped amorphous apatite material and crystalline apatite material

A technology of element doping and apatite, which is applied in the field of biomedical materials, can solve the problems of unfavorable new bone growth and poor biological activity of artificial bone scaffolds, and achieve the effect of high affinity

Inactive Publication Date: 2016-03-30
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the invention is to address the inconsistency between the degradation rate of existing hydroxyapatite (HA) and tricalcium phosphate (β-TCP) artificial bone materials and the rate of new bone formation (HA crystals are difficult to degrade, and β-TCP degrades faster), which is not conducive to New bone growth, while the bioactivity of HA and β-TCP artificial bone scaffolds are poor, etc., provide a Sr and Mg element doped amorphous apatite material and crystalline apatite material, Sr, Mg element doped It can improve the biological activity of apatite material and has important clinical application value

Method used

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  • Sr and Mg doped amorphous apatite material and crystalline apatite material
  • Sr and Mg doped amorphous apatite material and crystalline apatite material
  • Sr and Mg doped amorphous apatite material and crystalline apatite material

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Experimental program
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Effect test

Embodiment 1

[0045] Raw materials and requirements: Ca(NO 3 ) 2 (analytical pure), (NH 4 ) 2 HPO 4 (analytical pure) and NH 3 ·H 2 O (analytically pure).

[0046] Rapid precipitation: 0.09mol of Ca(NO 3 ) 2 Dissolve in 1L deionized water to obtain solution A(Ca(NO 3 ) 2 Concentration is 0.09mol / L), with magnetic stirring 5min (500rpm), 0.06mol of (NH 4 ) 2 HPO 4 Dissolved in 1L deionized water to obtain solution B ((NH 4 ) 2 HPO 4 Concentration is 0.06mol / L), with magnetic stirring 5min (500rpm), the pH value of these two kinds of solutions is adjusted to 9-10 with the ammonia solution (analytical grade) of 25% by mass percent, then solution A is poured into solution rapidly In B, stir magnetically for 30s (500rpm), filter with a suction filter bottle, and wash with deionized water and alcohol three times respectively to obtain a milky white material. Freeze-dried for 24 hours to obtain non-doped amorphous apatite powder [Ca9(HPO 4 )(PO 4 ) 5 (OH)]( figure 1 (a), figu...

Embodiment 2

[0049] In this example, 0.0772mol of Ca(NO 3 ) 2 and 0.0128mol of Mg(NO 3 ) 2 Dissolve in 1L deionized water to obtain solution A(Ca(NO 3 ) 2 The concentration is 0.0772mol / L, Mg(NO 3 ) 2 Concentration is 0.0128mol / L), all the other parts are identical with embodiment 1, lyophilized 24 hours, obtain the (Mg / (Ca+Mg)=14.25%) amorphous apatite powder ( image 3 ). Carry out heat treatment in heat treatment furnace 800 ℃ for 3 hours to obtain the β-TCP crystal material ( Figure 5 (e)).

Embodiment 3

[0051] In this example, 0.0813mol of Ca(NO 3 ) 2 and 0.0087mol of Mg(NO 3 ) 2 Dissolve in 1L deionized water to obtain solution A(Ca(NO 3 ) 2 The concentration is 0.0813mol / L, Mg(NO 3 ) 2The concentration is 0.0087 mol / L), and the rest is the same as in Example 1, and freeze-dried for 24 hours to obtain amorphous apatite powder doped with 9.67% Mg molar percentage (Mg / (Ca+Mg)=9.67%). Carry out heat treatment at 120 ℃ in the heat treatment furnace for 3 hours to obtain the nano calcium-deficient hydroxyapatite crystal material ( Figure 4 (b)).

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Abstract

The invention discloses an Sr and Mg doped amorphous apatite material and crystalline apatite material, belonging to the field of biomedical materials. The different concentrations of Sr and Mg doped amorphous apatite material is rapidly prepared by using Ca(NO3)2, Mg(NO3)2, Sr(NO3)2, (NH4)2HPO4 and ammonia-water as raw materials and then is transformed to the different concentrations of Sr and Mg doped nano calcium-deficient hydroxyapatite or nano tricalcium phosphate material through heat treatment. Compared with traditional hydroxyapatite crystalline materials, the amorphous material has higher solubility. The amorphous apatite material and the crystalline apatite material have the beneficial effects that after Sr and Mg doping, Sr can achieve the effects of promoting new bone formation, reducing reabsorption of bone, adjusting calcium metabolism and reducing the activity of osteoclast, and Mg can achieve the effects of affecting early growth of bone substances and regulating growth and remodelling of the bone substances; therefore the synthesized amorphous apatite and the crystallized product thereof have important roles in the fields of bone repair and bone transplantation.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to an amorphous apatite material and a crystalline apatite material doped with Sr and Mg elements. Background technique [0002] Bones are the scaffolding of the human body, with important functions such as support, protection, and hematopoiesis, and are important tissues and organs of the human body. So far, the materials used in the clinical treatment of bone defect repair worldwide mainly include metal alloy materials, polymer materials and bioceramic materials. Among them, bioceramic materials mainly include hydroxyapatite (HA), β-phase tricalcium phosphate (β-TCP) and a mixture of the two (two-phase calcium phosphate materials). For bone defect repair, hydroxyapatite ceramics basically do not degrade in vivo, which is not conducive to new bone regeneration; while β-phase tricalcium phosphate ceramics can be degraded in vivo, but in some applications, its degradati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32A61L27/12A61L27/04A61L27/54A61L27/58A61K6/033A61K6/04B82Y40/00A61K6/838
CPCA61K6/838A61K6/84A61L27/047A61L27/12A61L27/54A61L27/58A61L2300/102A61L2430/02A61L2430/12C01B25/325C01P2002/72C01P2002/82C01P2004/04C01P2004/64A61L27/04B82Y40/00C01B25/32
Inventor 张兴曹磊杨锐
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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