Selenium-doped hydroxyapatite and preparation method thereof

A technology of hydroxyapatite and apatite, which is applied in the direction of chemical instruments and methods, phosphorus compounds, nanotechnology for materials and surface science, etc., to achieve the effect of simple process, high output and convenient large-scale production

Active Publication Date: 2011-11-23
ASIA BIOMATERIALS WUHAN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there has been no report on hydroxyapatite powder materials doped with selenium. How to combine the application of selenium with hydroxyapatite is still an unresolved problem.

Method used

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  • Selenium-doped hydroxyapatite and preparation method thereof
  • Selenium-doped hydroxyapatite and preparation method thereof
  • Selenium-doped hydroxyapatite and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Select and analyze pure calcium nitrate, diamine hydrogen phosphate, and sodium selenite, and synthesize 0.1% selenium-doped nano-scale hydroxyapatite through this preparation method. The specific steps are:

[0036] (1) Add 12.398g analytically pure calcium nitrate to 140ml distilled water; 4.156g analytically pure diammonium hydrogen phosphate into 320ml distilled water, 0.0083g analytically pure sodium selenite into 20ml distilled water, stir until completely dissolved;

[0037] (2) Adjust the pH value of the calcium nitrate solution to 9 with ammonia water, and use a thermostatic magnetic stirrer to raise its temperature to 80°C;

[0038] (3) Under the conditions described in step (2), slowly drop the diammonium hydrogen phosphate solution in step (1) into the calcium nitrate solution, and control the dropping rate so that the dropping process lasts for 30 minutes;

[0039] (4) In step (3), when the reaction continues for 15 minutes, slowly drop 3 ml of sodium polyacrylate ...

Embodiment 2

[0045] Select and analyze pure calcium nitrate, diammonium hydrogen phosphate, sodium selenite, and synthesize 1% selenium-doped nano-scale hydroxyapatite through this preparation method. The specific steps are:

[0046] (1) Add 7.085g analytically pure calcium nitrate to 280ml distilled water; 2.540g analytically pure disodium hydrogen phosphate into 280ml distilled water, and 0.047g analytically pure sodium selenite into 40ml distilled water. Stir until completely dissolved

[0047] (2) Adjust the pH value of the calcium nitrate solution to 9 with ammonia water, and use a thermostatic magnetic stirrer to raise its temperature to 80°C;

[0048] (3) While maintaining the conditions described in step (2), slowly drop the diammonium hydrogen phosphate solution in step (1) into the calcium nitrate solution. Control the dripping speed so that the dripping process lasts for 30 minutes;

[0049] (4) In step (3), when the reaction continues for 15 minutes, slowly drop 1.5 ml of sodium poly...

Embodiment 3

[0055] Select and analyze pure calcium nitrate, diammonium hydrogen phosphate, sodium selenite, and synthesize 1% selenium-doped nano-scale hydroxyapatite through this preparation method. The specific steps are:

[0056] Choose to analyze pure calcium nitrate, diammonium hydrogen phosphate, sodium selenite. The process of synthesizing 5% selenium-doped hydroxyapatite through this process is:

[0057] (1) Add 3.542g analytically pure calcium nitrate into 140ml distilled water; 1.150g analytically pure diammonium hydrogen phosphate into 140ml distilled water, and 0.115g analytically pure sodium selenite into 20ml distilled water. Stir until completely dissolved

[0058] (2) Adjust the pH value of the calcium nitrate solution to 9.5 with ammonia water, and use a constant temperature magnetic stirrer to raise its temperature to 80°C;

[0059] (3) While maintaining the conditions described in step (2), slowly drop the diammonium hydrogen phosphate solution in step (1) into the calcium ni...

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Abstract

The invention discloses selenium-doped hydroxyapatite and a preparation method thereof. The selenium-doped hydroxyapatite which is obtained by the preparation method has an apatite structure; and a selenium element partially replaces the positions of phosphate radical and/or hydroxyl in the hydroxyapatite crystal in the form of seleninic acid radical. The yield of selenium-doped hydroxyapatite ishigh and the selenium-doped hydroxyapatite has high dispersibility.

Description

technical field [0001] The invention belongs to the technical field of biomaterials. Background technique [0002] Synthetic hydroxyapatite is an excellent hard tissue replacement material with good compatibility with human tissue. It is clinically used in the repair and replacement of human hard tissue, such as artificial bone, dental implant, bone filling material, artificial joint etc., can improve the osteogenic ability of bone implant materials. Also available as orthopedic implants (e.g. saddle nose fillers). In addition, medicinal hydroxyapatite also has some special properties, such as inhibiting the growth of some tumor cells. [0003] Selenium is an important trace element essential to the human body. Trace amounts of selenium have strong antioxidant and anticancer effects. It can also remove free radicals in the body, eliminate toxins in the body, resist oxidation, effectively inhibit the production of lipid peroxides, prevent blood clots, remove cholesterol,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82Y40/00B82Y30/00
Inventor 张胜民刘咏辉
Owner ASIA BIOMATERIALS WUHAN CO LTD
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