Method for preparing hydroxyapatite crystal whisker porous ceramic support material

A technology of hydroxyapatite and porous ceramics, applied in the field of biomedical materials, can solve the problems of low mechanical strength, limited application range, poor bonding between slurry and organic foam, etc.

Active Publication Date: 2016-11-16
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the foamed ceramics prepared by the organic foam impregnation method have various deficiencies, such as low mechanical strength, poor bonding between the slurry and the organic foam, and limited application range.

Method used

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  • Method for preparing hydroxyapatite crystal whisker porous ceramic support material
  • Method for preparing hydroxyapatite crystal whisker porous ceramic support material
  • Method for preparing hydroxyapatite crystal whisker porous ceramic support material

Examples

Experimental program
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Effect test

Embodiment 1

[0026] A method for preparing a hydroxyapatite whisker porous ceramic support material, the specific operations are as follows:

[0027] (1) Place a beaker with 1L of distilled water on a magnetic stirrer for stirring, add 80ml of silica gel, 24g of potassium laurate, 8g of cellulose, and 6g of sodium stearate in sequence, and stir thoroughly to completely dissolve the raw materials and produce a large amount of Then gradually add 160g HAP whiskers in 10 times, and finally add 10gKGM, stir well, so that the slurry can reach the condition that can be extruded;

[0028] (2) Use a mold to extrude the slurry into sample A with a regular porous structure, pay attention to the shape of the molded sample and the integrity of the pores.

[0029] (3) Put sample A in a -80°C refrigerator for 12 hours, take the frozen sample out of the refrigerator, and dry it in a freeze dryer (at a temperature of -30°C and a pressure of 20Pa) for 12 hours. After drying, put Cut the sample into a regul...

Embodiment 2

[0034] A method for preparing a hydroxyapatite whisker porous ceramic support material, the specific operations are as follows:

[0035] (1) Place a beaker with 1L of distilled water on a magnetic stirrer for stirring, add 80ml of silica gel, 30g of potassium laurate, 10g of cellulose, and 7g of sodium stearate in sequence, and stir thoroughly to completely dissolve the raw materials and produce a large amount of Then gradually add 300g HAP whiskers in 10 times, and finally add 14gKGM, stir well, so that the slurry can reach the condition that can be extruded;

[0036] (2) Use a mold to extrude the slurry into sample A with a regular porous structure, pay attention to the shape of the molded sample and the integrity of the pores.

[0037] (3) Put sample A into -60℃ refrigerator to freeze for 6 hours, take out the frozen sample from the refrigerator, and dry it in a freeze dryer (at a temperature of -35℃ and a pressure of 25Pa) for 14 hours. After drying, put Cut the sample in...

Embodiment 3

[0042] A method for preparing a hydroxyapatite whisker porous ceramic support material, the specific operations are as follows:

[0043] (1) Place a beaker with 1L of distilled water on a magnetic stirrer for stirring, add 80ml of silica gel, 48g of potassium laurate, 16g of cellulose, and 8g of sodium stearate in sequence, and stir thoroughly to completely dissolve the raw materials and produce a large amount of Then gradually add 240g HAP whiskers in 15 times, and finally add 12gKGM, stir well, so that the slurry can reach the condition that can be extruded;

[0044] (2) Use a mold to extrude the slurry into sample A with a regular porous structure, pay attention to the shape of the molded sample and the integrity of the pores.

[0045] (3) Put sample A in a refrigerator at -50°C for 24 hours, take the frozen sample out of the refrigerator, and dry it in a freeze dryer (at a temperature of -40°C and a pressure of 30 Pa) for 18 hours. After drying, put Cut the sample into a ...

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Abstract

The invention discloses a method for preparing a hydroxyapatite crystal whisker porous ceramic support mainly used for bone repair and belongs to the field of biomedical materials. According to the method, hydroxyapatite crystal whisker is used as the raw material, potassium laurate is used as a foaming agent, carboxymethylcellulose is used as a foam stabilizer, a ceramic foam body is obtained through stir-foaming, a ceramic blank is obtained through extrusion forming and freeze drying, and then the hydroxyapatite crystal whisker porous ceramic support is obtained through sintering. The porous ceramic material prepared with the method has honeycomb straight-through holes with diameters of 10-1000 microns and side wall holes with diameters of 1-400 microns. The method has the advantages that processes are simple and controllable, raw material cost is low, and production period is short. The modified hydroxyapatite crystal whisker porous ceramic support prepared with the method has qualified cytotoxicity, high degradation property and certain biological activity. Therefore, industrial production and clinical application can be achieved.

Description

technical field [0001] The invention relates to a preparation method of a hydroxyapatite whisker porous ceramic support material, which is mainly used for bone repair and belongs to the field of biomedical materials. Background technique [0002] As an important part of bone tissue engineering research, the preparation of bone tissue engineering scaffolds has consistently attracted the attention of researchers. Bone tissue engineering scaffolds must have appropriate porosity to facilitate cell adhesion and propagation. At the same time, in order to ensure the mechanical strength of the porous scaffold, its pore size is also limited. Therefore, scaffolds for bone tissue engineering often have intricate pore structures. In addition, in order to facilitate its application in the field of tissue engineering, the scaffold material should also have good biocompatibility. [0003] Porous ceramics as a new type of material, its main advantage is that the excellent performance of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B38/10C04B35/447C04B35/81C04B41/85A61L27/56A61L27/02A61L27/12A61L27/10
CPCA61L27/025A61L27/10A61L27/12A61L27/56A61L2430/02C04B35/447C04B35/803C04B38/106C04B41/5035C04B41/85C04B2235/3418C04B2235/96C04B41/4535C04B41/0072C04B38/0003C04B38/0074C04B38/0051C04B38/0054
Inventor 陈庆华黄洁颜廷亭
Owner KUNMING UNIV OF SCI & TECH
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