Degradable hollow fiber membrane and application thereof

A fiber membrane and hollow technology, which is applied to degradable hollow fiber membranes and their application fields to achieve the effects of good surface smoothness, good biocompatibility, and adjustable pore size

Inactive Publication Date: 2012-07-18
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But at the same time, the environmental pollution caused by the disposal of these materials after use is also very serious, which has attracted widespread attention from all over the world.

Method used

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  • Degradable hollow fiber membrane and application thereof
  • Degradable hollow fiber membrane and application thereof
  • Degradable hollow fiber membrane and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) After pulverizing and drying polybutylene carbonate (PBC) with a molecular weight of 60,000, add polyethylene glycol (PEG) with a molecular weight of 8,000, and add the mixed raw materials to N,N-dimethylformamide , heated to 50°C, stirred and dissolved to form a solution, in which PBC accounted for 20% of the total mass, PEG accounted for 5% of the total mass, filtered the solution, and vacuum defoamed for 5 hours;

[0039] (2) Put the spinning solution into a barrel with heating and heat preservation function, keep the temperature at 50°C, extrude it with a spinneret for spinning hollow fibers, and solidify and shape it by wet spinning process. The parameters are: air layer Height 0cm, coagulation bath water, temperature 20°C; single-stage stretching, warm water bath as stretching medium, warm water bath temperature is 25°C, stretching ratio is 1.5 times; then remove solvent and porogen in warm water, in nitrogen Drying under protection, after sterilization treatm...

Embodiment 2

[0042] (1) After pulverizing and drying polybutylene carbonate (PBC) with a molecular weight of 100,000, add polyvinyl alcohol (PVA) with a molecular weight of 75,000, and add the mixed raw materials to N,N-dimethylformamide , heated to 40°C, stirred and dissolved to make a solution, in which PBC accounted for 25% of the total mass, and PVA accounted for 12% of the total mass, filtered the solution, and vacuum defoamed for 7h;

[0043](2) Put the spinning solution into a barrel with heating and heat preservation function, keep the temperature at 40°C, extrude it with a spinneret for spinning hollow fibers, and solidify and shape it by dry-wet spinning process. The parameters are: Air layer height 7cm, coagulation bath water, temperature 20°C; the stretching is carried out in two stages, the warm water bath is used as the stretching medium, the temperature of the warm water bath is 35°C, and the stretching ratio is 4 times; The pore agent is air-dried and sterilized to obtain t...

Embodiment 3

[0046] (1) After pulverizing and drying polybutylene carbonate (PBC) with a molecular weight of 150,000, adding sodium chloride micropowder with a diameter of 0.8 μm, adding the mixed raw materials into acetone, heating to 55°C, stirring and dissolving to prepare into a solution, in which PBC accounts for 25% of the total mass, sodium chloride micropowder accounts for 2% of the total mass, the solution is filtered, and vacuum degassed for 5 hours;

[0047] (2) Put the spinning solution into a barrel with heating and heat preservation function, keep the temperature at 50°C, extrude it with a spinneret for spinning hollow fibers, and solidify and shape it by wet spinning process. The parameters are: spinneret There is no air layer between the head and the coagulation bath, the coagulation bath water, the temperature is 10°C; the stretching is carried out in three stages, the warm water bath is used as the stretching medium, the temperature of the warm water bath is 30°C, and the ...

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Abstract

The invention relates to a degradable hollow fiber membrane and application thereof. The degradable hollow fiber membrane comprises polybutylene carbonate (PBC) as a completely biodegradable material, wherein the PBC has a molecular weight is 0.01-0.25 million. The degradable hollow fiber membrane is applied to tissue engineering as an artificial blood vessel repair material and a catheter stent material. A preparation method of the degradable hollow fiber membrane is simple, and can be used for preparing degradable hollow fiber membranes with different internal diameters, wall thicknesses, lengths and porosity in batches; and the degradable hollow fiber membrane has better mechanical property, is suitable for cell growth, has shorter degradation period, and also has better application prospect in the field of biological application.

Description

technical field [0001] The invention belongs to the field of fiber membrane and its application, in particular to a degradable hollow fiber membrane and its application. Background technique [0002] From the beginning of the twentieth century, with the discovery of reliable polymerization methods, as well as the great progress of polymer theory, physics and engineering technology, it led to and promoted a material revolution, which had a profound impact on the development of human history. influences. The use of polymer materials such as plastics, fibers and rubber has brought great convenience to people's lives. But at the same time, the environmental pollution caused by the discarding of these materials after use is also very serious, which has attracted the attention of all countries in the world. [0003] In order to reduce the pollution of waste polymer materials to the environment, the development of degradable materials is being gradually strengthened. All over th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/50B01D69/08
Inventor 沈新元邵成华卢新坤杨庆金晓懿
Owner DONGHUA UNIV
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