Hydroxyapatite crystal whisker with high length-diameter ratio and preparation method thereof

Abstract

The process of preparing hydroxyapatite crystal whisker in great length / diameter ratio includes mixing calcium source solution and phosphorus source solution in proper concentration under the protection of nitrogen while adding assistant for crystal to grow in certain direction, reflux reaction at proper acidity and temperature conditions for certain time, and transferring the reflux resultant to a pressure kettle for static hydrothermal growth to obtain hydroxyapatite crystal whisker in great length / diameter ratio and high purity. The process has the advantages of mild conditions, short preparation period, controllable length / diameter ratio and high product purity. In addition, the product has high bioactivity.

Description

technical field

[0001] The invention relates to a hydroxyapatite whisker and a preparation technology thereof, belonging to the field of chemical and biological materials. Background technique

[0002] Hydroxyapatite, chemical formula Ca 10 (PO 4 ) 6 (OH) 2 HA, referred to as HA, is the main inorganic component that constitutes the hard tissues (bones, teeth) of organisms. In bone tissue, HA exists in the form of needles and rod-shaped whiskers, and is skillfully combined with biological organic tissues such as collagen to form a HA / biopolymer composite material. Porous and interconnected HA microcrystals have different degrees of bioactivity, biocompatibility and biodegradability, have no toxic side effects and rejection, and can produce good osteoinductivity with organisms. Therefore, in recent years, HA It has rapidly developed into one of the widely used bone substitute materials, and has shown more and more broad application prospects in biotissue engineering scaff...