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Inversly crystallized collagen-hydroxyl apatite bone repairing material and preparing method thereof

A technology of hydroxyapatite bone and hydroxyapatite is applied in the field of reversed-phase crystalline collagen-hydroxyapatite bone repair material and its preparation, and can solve the problems of poor osteogenic effect, poor toughness, too fast degradation rate and the like

Inactive Publication Date: 2008-07-30
张立海 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, due to weak strength, poor toughness, fast degradation rate and poor bone formation effect, this kind of material has affected the clinical application.

Method used

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  • Inversly crystallized collagen-hydroxyl apatite bone repairing material and preparing method thereof
  • Inversly crystallized collagen-hydroxyl apatite bone repairing material and preparing method thereof
  • Inversly crystallized collagen-hydroxyl apatite bone repairing material and preparing method thereof

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Experimental program
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Effect test

Embodiment 1

[0045] According to the ratio of Ca:P=1:1.66 (molar ratio), 59.7mM H 3 PO 41 mol of 1M Ca(OH)2 was added dropwise, and the pH value was adjusted to 8 with 1N NaOH, and the reactant was precipitated to obtain a precipitate, which was crystalline hydroxyapatite. A collagen swelling solution with a solid content of 0.5% (weight concentration) is prepared by using 0.3% (weight concentration) of malonic acid solution as the swelling solution. Take 2 mg of the above crystalline hydroxyapatite powder, weigh 200 ml of collagen swelling solution according to the ratio of collagen: hydroxyapatite powder weight ratio of 1:2, disperse the crystalline hydroxyapatite powder in the collagen solution, and stir for 5 minutes , 500 rpm, so that the two are uniformly dispersed to obtain a collagen-hydroxyapatite dispersion. Pre-frozen at -20°C for 4 hours, and freeze-dried in a freeze dryer for 24 hours to obtain a reverse-phase crystalline collagen-hydroxyapatite scaffold. Add 0.25% (weight ...

Embodiment 2

[0053] According to the ratio of Ca:P=1:1.66 (molar ratio), 59.7mM H 3 PO 4 1 mol of 1M Ca(OH)2 was added dropwise, and the pH value was adjusted to 8 with 1N NaOH, and the reactant was precipitated to obtain a precipitate, which was crystalline hydroxyapatite. A collagen swelling solution with a solid content of 0.5% (weight concentration) is prepared by using 0.3% (weight concentration) of malonic acid solution as the swelling solution. Take 4 mg of the above-mentioned crystalline hydroxyapatite powder, weigh 200 ml of collagen swelling solution according to the ratio of collagen: hydroxyapatite powder weight ratio of 1:4, and disperse the crystalline hydroxyapatite powder in the collagen solution, 800 rpm Divide and stir for 8 minutes to disperse the two evenly to obtain a collagen-hydroxyapatite dispersion. Pre-frozen at -40°C for 4 hours and freeze-dried for 24 hours to obtain a reverse-phase crystalline collagen-hydroxyapatite scaffold. Add 0.25% (weight concentration...

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Abstract

The invention relates to a reversed-phase crystal collagen-hydroxyapatite bone repair material and a preparation method thereof. Hydroxyapatite microcrystal is dispersed in collagen swelling solution, whereof the pH value is adjusted to 8-12. The collagen and the hydroxyapatite are precipitated simultaneously through a reversed-phase crystal process and then the material of the invention is obtained through a freezing and drying process. The material prepared by the invention is formed by a reversed-phase crystal method, hydroxyapatite crystal is independently crystallized among the collagen fibers, and crystal nucleus of the hydroxyapatite crystal is the hydroxyapatite, whereof a space structure has the characteristics of a three-dimensional porous structure and aperture is 50-500Mum.

Description

Technical field: [0001] The invention relates to a reverse-phase crystalline collagen-hydroxyapatite bone repair material and a preparation method thereof. The reverse-phase crystalline collagen-hydroxyapatite bone repair material is prepared by using hydroxyapatite and collagen through a reverse-phase crystallization process , the material has superior mechanical properties and biological properties, and can be used for repairing bone defects caused by various conditions. The invention belongs to the technical field of biological materials. Background technique: [0002] Bone defects caused by trauma or tumor resection are very common in clinical practice. They not only lead to serious impairment of physiological functions of patients, but also seriously affect the appearance and image of patients, causing heavy mental burden to patients. Currently, bone repair materials clinically used mainly include autologous bone, allogeneic bone and biomaterials (inert metals, high mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/24
Inventor 张立海胡敏
Owner 张立海
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