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Composite bone cement and preparation method thereof

A bone cement and composite technology, applied in medical science, prosthesis, tissue regeneration, etc., can solve problems that have not been reported, and achieve the effects of improving injection performance, increasing osteoinductivity, and improving injectability

Active Publication Date: 2016-05-04
山东明德生物医学工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the present invention, calcium sulfate and calcium phosphate are directly mixed uniformly, supplemented with additives to prepare calcium sulfate calcium phosphate composites through steam heating method, and the additives are used to improve the injection performance, water collapse resistance, mechanical properties, etc. of calcium sulfate bone cement, and also It plays the role of crystal-transforming agent, guides calcium sulfate to crystal-transform calcium sulfate hemihydrate, avoids the introduction of impurities such as aluminum sulfate and other crystal-transforming agents, and supplements additives in the relevant content of the present invention. The study of cement powder has not been reported

Method used

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  • Composite bone cement and preparation method thereof
  • Composite bone cement and preparation method thereof
  • Composite bone cement and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The calcium sulfate salt is calcium sulfate dihydrate, the calcium phosphate salt is tricalcium phosphate, and the additive is polyethylene glycol. The method is as follows:

[0025] (1) Weigh 90% calcium sulfate dihydrate (99%) and tricalcium phosphate (1%) according to the mass percentage, supplemented with polyethylene glycol, and mix them evenly in a ball mill. The polyethylene glycol accounts for the total mass. 10%;

[0026] (2) Take it out and dry and grind in an oven at 70°C, then transfer the crystal in an autoclave at a temperature of 135°C and a pressure of 0.2MPa, and the reaction time is 8h;

[0027] (3) After the reaction, it is placed in an oven at 100°C for drying for 12 hours and ground evenly to obtain bone cement powder;

[0028] (4) Weigh 5 g of bone cement powder, add the powder to water according to a powder-to-liquid mass ratio of 3:1, stir evenly, and solidify to obtain bone cement.

[0029] Observe the microscopic appearance of the prepared bone cement p...

Embodiment 2

[0032] The calcium sulfate salt is calcium sulfate dihydrate, the calcium phosphate salt is composed of tricalcium phosphate and strontium hydroxyapatite, and the additive is polyethylene glycol. The method is as follows:

[0033] (1) Weigh 95% calcium sulfate dihydrate (65%), tricalcium phosphate, and strontium hydroxyapatite (35%) according to mass percentage, supplemented with polyethylene glycol, and mix them evenly in a ball mill. Diol accounts for 5% of the total mass;

[0034] (2) Take it out and dry and grind in an oven at 70°C, then transfer the crystal in an autoclave with a temperature of 120°C and a pressure of 0.1MPa, and the reaction time is 8h;

[0035] (3) After the reaction, put it in an oven at 80°C for 12 hours to dry, and grind evenly to obtain bone cement powder;

[0036] (4) Weigh 5 g of bone cement powder, add the powder to water according to the powder-to-liquid mass ratio of 1:1, stir evenly, and solidify to obtain bone cement.

[0037] Place the bone cement in...

Embodiment 3

[0039] The calcium sulfate salt is calcium sulfate dihydrate, the calcium phosphate salt is hydroxyapatite, and the additive is polyethylene glycol. The method is as follows:

[0040] (1) Weigh 99% calcium sulfate dihydrate (90%) and hydroxyapatite (10%) according to the mass percentage, supplemented with polyethylene glycol, and mix them evenly in a ball mill. The polyethylene glycol accounts for the total mass. 1%;

[0041] (2) Take it out and dry and grind in an oven at 70°C, then transfer the crystal in an autoclave at a temperature of 145°C and a pressure of 0.26MPa, and the reaction time is 5h;

[0042] (3) After the reaction, put it into an oven at 90°C for 12 hours to dry, and grind evenly to obtain bone cement powder;

[0043] (4) Weigh 5 g of bone cement powder, add the powder to water according to a powder-to-liquid mass ratio of 2.5:1, stir evenly, and solidify to obtain bone cement.

[0044] The prepared bone cement powder was characterized by XRD and compared with the dif...

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Abstract

The invention relates to composite bone cement for repairing bone tissues and a preparation method thereof. The bone cement is prepared from the following components in percentage by mass: 90-99.9 percent of calcium sulfate / calcium phosphate composite and 0.1-10 percent of additives. The method comprises the following steps: uniformly mixing raw materials, drying in an oven at 70 DEG C, grinding, and performing a crystal transformation reaction in a high-pressure kettle at a temperature of 120-200 DEG C and a pressure of 0.1-1MPa for 3-8 hours; after reaction, drying in an oven at 80-100 DEG C for 12 hours, and uniformly grinding to obtain bone cement powder; and weighing the bone cement powder, adding the powder into a liquid in a powder-liquid mass ratio of (1-3):1, uniformly stirring, and curing to obtain the bone cement. The prepared bone cement has the advantages of high tensile strength, good injection performance, good water scattering resistance, controllable degradation and the like, has excellent biological activity, compatibility and safety, and is used for fixing multiple bone fractures and filling bone defects.

Description

Technical field [0001] The invention relates to a composite bone cement used for bone tissue repair and a preparation method, which is mainly used in the fields of biomedical materials and the like. Background technique [0002] Artificial bone repair is currently an ideal method for the treatment of bone defects. As a traditional bone repair material, calcium sulfate has good application prospects in bone repair due to its good biocompatibility and osteoconductivity. Since Dressman first used calcium sulfate to successfully cure bone defects, calcium sulfate bone repair materials have gradually developed. In 1996, the American Wright company developed surgical grade calcium sulfate bone cement. It has passed the US FDA and European certification. Recently, a new generation of injectable bone graft material MIIG bone cement has been produced, which not only has clinical curative effect, but also has more accurate and stable biological properties, and provides an effective way fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/18A61L27/12A61L27/04A61L27/50
CPCA61L27/425A61L27/50A61L2430/02C08L1/02C08L5/04C08L5/08C08L71/00
Inventor 李朝阳崔永顺夏文飞刘伟铭邸勋董妍君吕维加
Owner 山东明德生物医学工程有限公司
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